Brugada Type Electrocardiographic Changes Induced by Concomitant Use of Lithium and Propafenone in Patient with Wolff–Parkinson–White Syndrome

Iliadis, Ilias; Papanastasiou, Soultana; Lambrou, A.; Katsaris, George

doi:10.1111/j.1540-8159.2007.00762.x

Cited by 16 publications

(3 citation statements)

References 10 publications

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“…The association between BS and ventricular preexcitation was first described in 2001 by Eckardt et al . Subsequently, six other cases of this association have been reported . The uniqueness of this case was that the typical ST segment elevation occurred only after administration of propafenone for pharmacological treatment of WPW syndrome.…”

Section: Discussionmentioning

confidence: 68%

Coexistence of Wolff–Parkinson–White and Brugada Syndrome: Mere Curiosity?

Kaiser

Sacilotto

Darrieux

et al. 2014

Noninvasive Electrocardiol

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The association between Brugada syndrome (BS) and ventricular preexcitation is a rare condition, with sporadic cases already reported. We report the case of a 29-year-old man, with palpitation unrelated to physical or emotional stress. The electrocardiogram of the first visit revealed a ventricular preexcitation pattern and an end-conduction delay, with negative T wave in V1 and intraventricular conduction disturbance in V2 (atypical for BS). The typical aspect of BS occurred after introduction of propafenone for the prevention of atrioventricular tachycardia. We discuss the recognition of this rare association, the proarrhythmic effects of some drugs, treatment options, and prognosis.

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Section: Discussionmentioning

confidence: 68%

Coexistence of Wolff–Parkinson–White and Brugada Syndrome: Mere Curiosity?

Kaiser

Sacilotto

Darrieux

et al. 2014

Noninvasive Electrocardiol

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“…Lithium has been known to have potentially cardiotoxic effects for several decades; however, the first two cases of lithium unmasked Brugada syndrome were reported in 2005 [5]. There were 13 reported cases of lithium unmasked Brugada pattern on ECG as shown in Table 1 [5,[7][8][9][10][11][12][13][14][15][16]. Including our patient, ten were male and four were female.…”

Section: Discussionmentioning

confidence: 78%

“…However, further studies are required to answer this question. Inpatient monitoring for about 36-48 hours, which corresponds to the initial half-life of lithium or until lithium levels are therapeutic, appears to be reasonable [5,[7][8][9][10][11][12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Lithium-Induced Brugada Pattern: A Case Report and Review of Literature

Ravi

Serafini

Pulipati

et al. 2020

Cureus

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Lithium-induced type 1 Brugada pattern in asymptomatic patients is an uncommon occurrence that is challenging to manage and to estimate the risk of sudden cardiac death (SCD). We describe a case of a 74-year-old woman who presented with type 1 Brugada pattern while on lithium therapy. Her lithium level was within the therapeutic range at the time of presentation. There was no evidence of ventricular ectopy or malignant arrhythmias. Review of electrocardiogram (ECG) prior to initiation of lithium therapy demonstrated type 3 Brugada pattern. Lithium was promptly discontinued, and the patient was closely monitored in the hospital for 48 hours with serial ECGs and telemetry, as her lithium levels decreased. The Brugada pattern resolved on day 10 of discontinuation of lithium therapy and no further intervention was performed. Early diagnosis and prompt discontinuation of lithium leads to the resolution of type 1 Brugada pattern and may reduce the risk of SCD. The case highlights the importance of obtaining baseline ECG when initiating lithium especially in patients with type 2 or 3 Brugada pattern and provides an overview of the serial changes in ECG pattern until resolution following discontinuation of lithium. Electrophysiology study for risk stratification in asymptomatic patients does not appear to provide any additional benefit.

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Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy

Antzelevitch

Viskin

2013

Electrical Diseases of the Heart

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Brugada Type Electrocardiographic Changes Induced by Concomitant Use of Lithium and Propafenone in Patient with Wolff–Parkinson–White Syndrome

Cited by 16 publications

References 10 publications

Coexistence of Wolff–Parkinson–White and Brugada Syndrome: Mere Curiosity?

Coexistence of Wolff–Parkinson–White and Brugada Syndrome: Mere Curiosity?

Lithium-Induced Brugada Pattern: A Case Report and Review of Literature

Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy

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