Brugada syndrome associated with an autonomic disorder

Nomura, Masahiro; Nada, Teru; Kondo, Yuki; Yukinaka, Michiko; Saito, Ken; Ito, Susumu; Mori, Hiromu; Nakaya, Yutaka; Shinomiya, H

doi:10.1136/hrt.80.2.194

Cited by 31 publications

(14 citation statements)

References 9 publications

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“…Previous studies have demonstrated that various central and autonomic nervous system abnormalities can result in ST-segment elevation with or without CK elevation (22)(23)(24)(25)(26)(27). The autonomic nervous function also participates in the formation of Brugadatype ECG (28,29), and unbalanced autonomic nerve function has been thought to play an important role in inducing Brugada-type ECG (30). The present case also experienced symptoms of severe neuropathy secondary to thiamine deficiency.…”

Section: Discussionmentioning

confidence: 57%

ST-segment Elevation of Electrocardiogram in a Patient with Shoshin Beriberi

et al. 2005

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Section: Discussionmentioning

confidence: 57%

ST-segment Elevation of Electrocardiogram in a Patient with Shoshin Beriberi

et al. 2005

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“…They confirm and extend previous observations by radionuclide studies using 123 I-MIBG-SPECT, which demonstrated regional reduction of transporter-mediated neuronal catecholamine reuptake (uptake 1) in 2 case reports of Brugada syndrome. 16,17 In contrast, Miyazaki et al 11 did not find abnormalities of 123 I-MIBG-SPECT in 3 of 4 patients with Brugada syndrome and concluded that autonomic dysfunc- Table 1). 123 I-MIBG uptake is locally reduced in inferior and inferolateral myocardial wall despite homogeneous myocardial blood flow ( 99m Tctetrofosmin-SPECT). In this patient, additional early image acquisition (10 minutes post-injection) was performed.…”

Section: Discussionmentioning

confidence: 94%

Cardiac Autonomic Dysfunction in Brugada Syndrome

et al. 2002

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Background-Patients with Brugada syndrome present with characteristic ECG abnormalities (atypical right bundlebranch block and ST-segment elevation) and life-threatening ventricular tachyarrhythmias despite structurally normal hearts. Involvement of the autonomic nervous system is suggested by the occurrence of ventricular tachyarrhythmias and sudden death at rest or during sleep and by changes of typical ECG signs under pharmacological modulation of the myocardial autonomic tone. Methods and Results-This study investigated the presynaptic cardiac neuronal reuptake of norepinephrine (uptake 1) in 17 patients with Brugada syndrome and 10 age-matched control subjects with the use of the norepinephrine analogue

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“…11 Matsuo et al reported that VF occurred more frequently during the night than during the day, and was most likely between midnight to early morning, which they suggested was caused by increased vagal tone and decreased sympathetic tone. 12 We compared the autonomic tone evaluated 2-3 days after a VF attack with that evaluated 3 weeks after the attack in patients with Brugada syndrome and found that the increase in vagal tone and decrease in the sympathetic tone were significant 2-3 days after the VF attack, which suggested that a transient autonomic imbalance is associated with the occurrence of VF.…”

Section: Discussionmentioning

confidence: 97%

Autonomic Imbalance as a Property of Symptomatic Brugada Syndrome

Nakazawa¹,

Sakurai

Takagi³

et al. 2003

Circ J

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The autonomic properties in 27 patients with the electrocardiographic morphology of Brugada syndrome were investigated using 24-h Holter monitoring: 10 patients had a history of ventricular fibrillation (VF; Br-VF group) and 17 did not (Br-N group); there were 26 healthy subjects enrolled in this study. All subjects underwent normal Holter data monitoring and power spectral analysis. Few extrasystoles were observed in either group, and the mean heart rate (HR), maximum HR, and total heart beats over 24 h were obtained. All of these measurements were significantly lower in the Br-VF group than in the Br-N and healthy subject groups. The RR interval variability was analyzed over 512 beats every 10 min. The high-frequency component (0.15-0.40 Hz; HF), low-frequency component (0.04-0.15 Hz; LF) and the LF/HF ratio were analyzed over 24 h. The HF was significantly higher and LF/HF ratio lower in the Br-VF group than in the healthy subjects. The HF was also significantly higher than in the Br-N group. During the night (00.00-05.00 h), the HF was significantly higher in the Br-VF group, and the LH/HF lower. During the day (12.00-17.00 h), the HF was significantly higher in the Br-VF group, but there was no difference in the LF/HF. These results indicate that high vagal tone and low sympathetic tone are specific properties of symptomatic Brugada syndrome.

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Brugada syndrome associated with an autonomic disorder

Cited by 31 publications

References 9 publications

ST-segment Elevation of Electrocardiogram in a Patient with Shoshin Beriberi

ST-segment Elevation of Electrocardiogram in a Patient with Shoshin Beriberi

Cardiac Autonomic Dysfunction in Brugada Syndrome

Autonomic Imbalance as a Property of Symptomatic Brugada Syndrome

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