Brugada Syndrome and Carbohydrate Metabolism

Chanavirut, Raoyring; Leelayuwat, Naruemon

doi:10.15406/jccr.2017.08.00294

Cited by 2 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This association was further investigated in Nogami et al who found the accentuation of ST-segment in high-risk Brugada syndrome patients following infusion of glucose or glucose and insulin solution, even with little to no isoelectric separation between the Brugada syndrome patients and controls [ 9 ]. Among the cases described by Haseeb et al in their scoping review, only 3 of the 22 cases included between 1978 and 2018 were comparable to our case in terms of a patient in DKA with relatively mild electrolyte abnormalities and acidosis, but also severe hyperglycemia inducing Brugada syndrome [ 7 ]. The type I diabetic patient described in this case provides an interesting addition to the discussion as hyperglycemia preempted the onset of Brugada pattern on EKG.…”

Section: Discussionsupporting

confidence: 55%

“…In a scoping review conducted by Haseeb et al, 22 cases of Brugada syndrome were examined in individuals who initially presented with DKA. While these reports often cite electrolyte abnormalities as the inciting factor of Brugada syndrome, they rarely discuss the role of hyperglycemia [ 7 ]. We postulate that hyperglycemia itself may be an inducing agent, even in the setting of relatively normal electrolytes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A rare case of Brugada syndrome induced by hyperglycemia

et al. 2021

View full text Add to dashboard Cite

Brugada syndrome is a rare genetic disorder of the cardiac sodium channels associated with an increased risk of sudden cardiac death. It is characterized by an electrocardiogram (EKG) showing a right bundle branch block with an elevation in the ST segment. This condition is associated with mutations in several pathologic genes including the most notable mutation in the SCN5A gene, which encodes for a voltage-gated cardiac sodium channel. The Brugada pattern on EKG can be spontaneous but can also be induced by a variety of etiologies including fever, electrolyte abnormalities, increased vagal tone and drugs such as sodium channel blockers, calcium channel blockers, tricyclic antidepressants and alcohol. One uncommon cause of Brugada syndrome is hyperglycemia. Of particular importance in diabetic patients, hyperglycemia can induce chronic cardiovascular complications as well as acute cardiac events via the induction of the Brugada pattern on EKG. We present a case of a 21-year-old non-insulin compliant diabetic man presenting to the Emergency Department with diabetic ketoacidosis (DKA) who exhibits the Brugada pattern EKG prior to developing ventricular tachycardia followed by cardiac arrest. The patient’s condition was induced by prolonged hyperglycemia in the setting of DKA with relatively mild electrolyte and pH abnormalities. Herein, this case is presented to highlight the Brugada pattern leading to cardiac arrest as a potential consequence of hyperglycemia and inform physicians on its incidence.

show abstract

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

A rare case of Brugada syndrome induced by hyperglycemia

et al. 2021

View full text Add to dashboard Cite

show abstract

Disease Modifiers of Inherited SCN5A Channelopathy

Verkerk

Amin

Remme

2018

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

To date, a large number of mutations in SCN5A, the gene encoding the pore-forming α-subunit of the primary cardiac Na+ channel (NaV1.5), have been found in patients presenting with a wide range of ECG abnormalities and cardiac syndromes. Although these mutations all affect the same NaV1.5 channel, the associated cardiac syndromes each display distinct phenotypical and biophysical characteristics. Variable disease expressivity has also been reported, where one particular mutation in SCN5A may lead to either one particular symptom, a range of various clinical signs, or no symptoms at all, even within one single family. Additionally, disease severity may vary considerably between patients carrying the same mutation. The exact reasons are unknown, but evidence is increasing that various cardiac and non-cardiac conditions can influence the expressivity and severity of inherited SCN5A channelopathies. In this review, we provide a summary of identified disease entities caused by SCN5A mutations, and give an overview of co-morbidities and other (non)-genetic factors which may modify SCN5A channelopathies. A comprehensive knowledge of these modulatory factors is not only essential for a complete understanding of the diverse clinical phenotypes associated with SCN5A mutations, but also for successful development of effective risk stratification and (alternative) treatment paradigms.

show abstract

Brugada Syndrome and Carbohydrate Metabolism

Cited by 2 publications

References 32 publications

A rare case of Brugada syndrome induced by hyperglycemia

A rare case of Brugada syndrome induced by hyperglycemia

Disease Modifiers of Inherited SCN5A Channelopathy

Contact Info

Product

Resources

About