Brugada Phenocopy: Morphological Classification and Importance of Provocative Testing

Brugada Phenocopy Induced by Electrolyte Disorder: A Transient Electrocardiographic Sign

“…Unfortunately; patient did not give consent to an Ajmaline provocation test. Our case seems to fulfill the Type-1-BrP class B criteria according to the classification proposed by Gottschalk et al 11 Patient is still doing well without any dysrhythmic events after 1 year.…”

“…Recently, Riera et al 5 proposed the terminology "Brugada Phenocopy" (BrP) as "an environmental condition that imitates one produced by a gene" defining the conditions with reversible Brugada-like-ECG patterns without true BrS. Our case seems to fulfill the Type-1-BrP class B criteria according to the classification proposed by Gottschalk et al 11 Patient is still doing well without any dysrhythmic events after 1 year. BrPs can be observed with many factors such as metabolic conditions (mainly electrolyte disorders), mechanical compressions on RV, ischemia, myo/pericardial diseases, pulmonary embolism, ECG recording modulations, drugs and substances.…”

Ischemia-induced Brugada phenocopy

“…The resolution of ECG changes immediately following resolution of occlusion; and the continued resolution of changes of the BrP on multiple repeat ECGs were reassuring that this was not BrS but BrP. Our patient would therefore be classified as type 1B BrP [7]. A database of drugs to avoid in BrS/BrP patients is available and should be reviewed with patients [8].…”

Brugada Phenocopy as a Dynamic Electrocardiographic Pattern during Acute Anterior Myocardial Infarction

“…This remains an important task to be resolved since ischemia may either induce a BrP or, inversely, unmask a true congenital BrS . In this clinical situation, current criteria allowed us to confirm the diagnosis of Type‐1, Class B BrP . Although the case presented here would require a challenge with a sodium channel blocker (ajmaline, flecainide, or procainamide), we did not perform these tests given the severe life‐threatening clinical situation and complete reversal of the ECG pattern once myocardial ischemia resolved.…”