Brugada‐Like Electrocardiographic Pattern Induced by Fever

Saura, Daniel; García‐Alberola, Arcadi; Carrillo, Pilar; Pascual, Domingo; Martínez‐Sánchez, Juan; Valdés, Mariano

doi:10.1046/j.1460-9592.2002.t01-1-00856.x

Cited by 95 publications

(59 citation statements)

References 11 publications

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“…4) Several clinical reports have indicated that a febrile state unmasked the syndrome or exacerbated ST-segment elevation and arrhythmogenesis. [10][11][12][13][14] Our present report supports the temperature-dependent nature of the underlying ion channelopathy of Brugada syndrome. It seems clear that this patient did have Brugada syndrome as indi- cated by a structurally normal heart and positive response to pilsicainide challenge.…”

Section: Discussionsupporting

confidence: 86%

Brugada-like Electrocardiographic Pattern Unmasked by Fever

et al. 2004

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SUMMARYBrugada syndrome is characterized by right bundle branch block morphology and STsegment elevation in the right precordial leads and a propensity to develop ventricular arrhythmias. Mutations in a cardiac sodium channel gene have been linked to this syndrome, and the ionic mechanisms responsible for the electrocardiographic phenotype are temperature-dependent. This case report describes a patient in whom a typical Brugada ECG pattern developed during fever and could be reproduced at normal body temperature by administration of pilsicainide. (Jpn Heart J 2004; 45: 163-167)

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Section: Discussionsupporting

confidence: 86%

Brugada-like Electrocardiographic Pattern Unmasked by Fever

et al. 2004

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“…Cardiac events (syncope or cardiac arrest) occur predominantly in males in the third and fourth decades of life, although presentation with cardiac arrest in neonates or children have been reported (104,777,820). Fever is a predisposing factor for cardiac arrest in the Brugada syndrome (800,818,(821)(822)(823)(824).…”

Section: Causes and Risk Factorsmentioning

confidence: 99%

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death

Zipes¹,

Camm²,

Borggrefe³

et al. 2006

Circulation

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“…Another known inducing factor is fever. Fever is known to cause ST elevation more prominent in BS and a BS-like ECG pattern in normal subjects (7,9).…”

Section: Discussionmentioning

confidence: 99%

Is coronary angiography an adequate diagnostic test to evaluate a young febrile patient with ST elevation?

Karabay

Kalaycı²,

Aung³

et al. 2012

Anadolu Kardiyol Derg

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Is coronary angiography an adequate diagnostic test to evaluate a young febrile patient with ST elevation?Genç febril ve ST elevasyonlu bir hasta değerlendirilmesinde koroner anjiyografi yeterli tetkik midir? IntroductionBrugada syndrome (BS) is a rare condition characterized by ST-segment elevation in the right precordial leads. It is associated with ventricular arrhythmias, and is responsible for 20% of sudden cardiac deaths (SCD). Fever can induce Brugada-like electrocardiographic (ECG) changes and precipitate ventricular fibrillation (VF).We would like to discuss a case of 31-year-old male who developed hypoxic ischemic encephalopathy. Case ReportA 31-year-old male was brought to our emergency room after about 15 minutes of apparent cardiac arrest. VF was seen, and he was defibrillated once with 200 J. After 10 minutes of successful resuscitation, he was transferred to intensive care unit. He was discharged without any further investigations. The surface ECG was consistent with type 1 Brugada pattern. Transthoracic echocardiography showed normal findings. Acute coronary syndromes, pulmonary embolism and electrolyte imbalance were excluded, and the patient was considered as a case of BS presenting with VF. Neurology consultation confirmed hypoxic ischemic encephalopathy, and the follow-up under the support of mechanical ventilation was continued in the intensive care unit.On the 12 th day, he had fever, and Methicillin-resistant Staphylococcus aureus was cultured from his tracheal aspirate. Dynamic changes on his surface ECG were detected during this period of increased body temperature. The apparently normal ECG at 36.9°C developed a pattern with a wider QRS complex and elevated J point at 38.8°C (Fig. 1). When the medical history was taken in detail, it was learned that 2 years ago, the patient underwent coronary angiography for a febrile illness accompanied by ST segment elevations and chest pain, probably due to myalgia. However, the coronary angiogram was found to be normal.

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Brugada‐Like Electrocardiographic Pattern Induced by Fever

Cited by 95 publications

References 11 publications

Brugada-like Electrocardiographic Pattern Unmasked by Fever

Brugada-like Electrocardiographic Pattern Unmasked by Fever

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death

Is coronary angiography an adequate diagnostic test to evaluate a young febrile patient with ST elevation?

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