Brucine-Loaded Ethosomal Gel: Design, Optimization, and Anti-inflammatory Activity

Abdallah, Marwa H.; Lila, Amr S. Abu; Unissa, Rahamat; Elsewedy, Heba S.; Elghamry, Hanaa A.; Soliman, Mahmoud E.

doi:10.1208/s12249-021-02113-8

Cited by 23 publications

(17 citation statements)

References 51 publications

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“…The encapsulation efficiency of transfersomal dispersions loaded with Silymarin (SmTFs) was determined by centrifuging the dispersion at 6.000 rpm for 60 min at 4 °C [ 6 ]. After centrifugation, the supernatant was taken and diluted, then the absorbance was monitored at λ max 287 nm using spectrophotometer (Shimadzu UV/VIS, Tokyo, Japan) [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…Due to the merits of small particle size, better drug retention, along with their targeting ability, nano-formulations have been considered ideal TDDSs. Accordingly, many approaches have been adopted to enhance the transdermal delivery of bioactive agents using nanoparticulate drug delivery systems, such as liposomes [ 5 ], transfersomes, ethosomes [ 6 ], dendrimers and microemulsions [ 7 ]. Liposomes as one of the transdermal delivery systems have been studied since the 1980s and have attracted a lot of interest.…”

Section: Introductionmentioning

confidence: 99%

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Experimental Design and Optimization of Nano-Transfersomal Gel to Enhance the Hypoglycemic Activity of Silymarin

et al. 2022

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Current advancements in the research investigations focused at using natural products to generate novel dosage forms with a potential therapeutic impact. Silymarin is a natural product obtained from the herb Silybum marianum that has been shown to have remarkable hypoglycemic activity. Owing to the low enteral absorption, instability in stomach secretion, and poor solubility of Silymarin, it was better to be produced as a topical dosage form. A three-factor, three-level Box Behnken (33 BB) design was constructed to develop 15 formulations using three independent variables (phospholipid concentration, surfactant concentration, and sonication time) and two dependent variables (encapsulation efficiency and in vitro drug release). The optimized formula was added to HPMC gel and the resulting transfersomal gel was investigated for its characteristics, in vitro, ex vivo and hypoglycemic behaviors. The pH of the Silymarin-loaded transfersomal gel was 7.05, the spreadability was 55.35 mm, and the viscosity was 6.27 Pa. Furthermore, Silymarin loaded transfersomal gel had the greatest transdermal flux (92.41 µg/cm2·h), which was much greater than all other formulations. In vivo observations revealed that Silymarin loaded transfersomal gel significantly reduced blood glucose levels, compared to either Silymarin gel or oral Silymarin suspension. The findings show that the developed transfersomal gel could be an effective carrier for Silymarin transdermal delivery.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experimental Design and Optimization of Nano-Transfersomal Gel to Enhance the Hypoglycemic Activity of Silymarin

et al. 2022

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“…The centrifugation method was used to determine the entrapment efficiency of the developed ginger extract-loaded niosomes. In brief, the niosomal dispersion was centrifuged at 6000 rpm for 1 h at 4 °C using a cooling centrifuge [ 36 ]. The concentration of the un-entrapped drug in the supernatant was determined spectrophotometrically at λ max of 273 nm [ 37 ].…”

Section: Methodsmentioning

confidence: 99%

Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity

Abdallah

Elghamry

Khalifa

et al. 2022

Gels

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Ginger, a natural plant belonging to the Zingeberaceae family, has been reported to have reasonable anti-inflammatory effects. The current study aimed to examine ginger extract transdermal delivery by generating niosomal vesicles as a promising nano-carrier incorporated into emulgel prepared with sesame oil. Particle size, viscosity, in vitro release, and ex vivo drug penetration experiments were performed on the produced formulations (ginger extract loaded gel, ginger extract loaded emulgel, ginger extract niosomal gel, and ginger extract niosomal emulgel). Carrageenan-induced edema in rat hind paw was employed to estimate the in vivo anti-inflammatory activity. The generated ginger extract formulations showed good viscosity and particle size. The in vitro release of ginger extract from niosomal formulation surpassed other formulations. In addition, the niosomal emulgel formulation showed improved transdermal flux and increased drug permeability through rabbit skin compared to other preparations. Most importantly, carrageenan-induced rat hind paw edema test confirmed the potential anti-inflammatory efficacy of ginger extract niosomal emulgel, compared to other formulations, as manifested by a significant decrease in paw edema with a superior edema inhibition potency. Overall, our findings suggest that incorporating a niosomal formulation within sesame oil-based emulgel might represent a plausible strategy for effective transdermal delivery of anti-inflammatory drugs like ginger extract.

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“…Specific load, usually 500 g was added over the slides for 1 min. The spreadability is calculated by measuring the diameter of the spreading formulation [ 42 ].…”

Section: Methodsmentioning

confidence: 99%

Tea Tree Oil Nanoemulsion-Based Hydrogel Vehicle for Enhancing Topical Delivery of Neomycin

Elsewedy

Shehata

Soliman

2022

Life

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The present investigation aims to improve the antimicrobial influence of certain antibacterial drugs, namely, neomycin (NEO), exploiting the benefits of natural oils such as tea tree oil (TTO). Therefore, a distinctive nanolipid formulation, namely, a nanoemulsion (NE), was developed using a Central Composite Factorial Design (CCD) approach depending on the amount of TTO and tween 80 as surfactant. The optimized NEO-NE formula exhibiting minimum globular size and maximum in vitro release was selected. For efficient topical delivery, NEO-NE was incorporated into a pre-formulated hydrogel. The developed NEO-NE-hydrogel was characterized by its physical characteristics such as pH, viscosity, and spreadability. Next, it was tested for stability under different conditions for 3 months. Ultimately, an irritation test was conducted followed by an antibacterial examination. The preparation demonstrated acceptable properties to be successfully applied topically. It showed non-significant changes in stability in both conditions up to 3 months storage when compared to a fresh preparation. It exhibited no irritation when applied on hairless animal skin. Finally, TTO revealed a good inhibition for the bacterial growth that could improve the influence of NEO antibacterial activity, indicating the efficiency of NE containing NEO prepared with TTO to be a promising antibacterial nanocarrier.

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Brucine-Loaded Ethosomal Gel: Design, Optimization, and Anti-inflammatory Activity

Cited by 23 publications

References 51 publications

Experimental Design and Optimization of Nano-Transfersomal Gel to Enhance the Hypoglycemic Activity of Silymarin

Experimental Design and Optimization of Nano-Transfersomal Gel to Enhance the Hypoglycemic Activity of Silymarin

Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity

Tea Tree Oil Nanoemulsion-Based Hydrogel Vehicle for Enhancing Topical Delivery of Neomycin

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