2010
DOI: 10.1345/aph.1p249
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Brucellosis-Induced Autoimmune Hemolytic Anemia Treated with Rituximab

Abstract: Novel therapeutic approaches with molecular agents such as rituximab may assist in treatment of considerably severe infectious pathogen-induced autoimmune hemolytic anemia that is refractory to first-line therapy.

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Cited by 12 publications
(11 citation statements)
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“…Autoimmune hemolysis is a rare entity in patients with brucellosis, with only three cases published in the literature thus far (14)(15)(16). In the present report, we described two patients with Brucella melitensis who presented with direct antiglobulin test (DAT)-positive AIHA.…”
Section: Anemia In Brucellosismentioning
confidence: 78%
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“…Autoimmune hemolysis is a rare entity in patients with brucellosis, with only three cases published in the literature thus far (14)(15)(16). In the present report, we described two patients with Brucella melitensis who presented with direct antiglobulin test (DAT)-positive AIHA.…”
Section: Anemia In Brucellosismentioning
confidence: 78%
“…The development of hemolytic anemia during the course of brucellosis has often been described in the context of microangiopathy (6)(7)(8)(9)(10)(11)(12); however, autoimmune hemolytic anemia (AIHA) is a rare clinical presentation of this disease (14)(15)(16). We herein describe the cases of two patients with acute brucellosis who presented with Coombs-positive AIHA.…”
Section: Introductionmentioning
confidence: 94%
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“…Hence, it presents difficulty in diagnosis because it mimics many other diseases. The disease also produces a variety of abnormalities in hematological parameters, including mostly leukopenia and mild anemia but, rarely, pancytopenia and thrombocytopenia . Furthermore, some cases of brucellosis with predominant hematological changes may mimic primary hematological disease …”
mentioning
confidence: 99%