Brucellosis in Infant after Familial Outbreak

Makis, Alexandros; Pappas, Georgios; Galanakis, E; Haliasos, Nikolaos; Siamopoulou, Antigoni

doi:10.3201/eid1408.080325

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…This fi nding suggests that when brucellosis is introduced into naive territories (i.e., those territories that were considered offi cially free of brucellosis), the primary source of infection for humans is direct contact with infected animals (i.e., exposure to abortion/delivery products) or domestic consumption of products produced on family farms (milk, raw cheese). However, environmental exposure can also occur, especially in infants and children, who are considered at lower risk for direct contact with potentially infected animals, as recently observed (6). This hypothesis appears to be consistent with the context of a naive setting, where preventive measures are not routinely implemented.…”

Section: Discussionsupporting

confidence: 69%

Reemergence of Human and Animal Brucellosis, Bulgaria

Russo¹,

Pasquali²,

Nenova³

et al. 2009

Emerg. Infect. Dis.

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Section: Discussionsupporting

confidence: 69%

Reemergence of Human and Animal Brucellosis, Bulgaria

Russo¹,

Pasquali²,

Nenova³

et al. 2009

Emerg. Infect. Dis.

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“…Possible causes of asymptomatic brucella infection in minors who were not in contact with diseased animals are (1) Minors have less direct contact with brucella, mainly due to ingestion of contaminated food or contaminated environment and aerosol infections [15][16][17] such as eating unpasteurized dairy products and local traditional foods containing dairy products [18] . (2) Minors, especially children, usually show fewer or milder symptoms than adult patients.…”

Section: Discussionmentioning

confidence: 99%

Screening household members of shepherds in brucellosis endemic areas in China and reporting follow-up results of asymptomatic infections

Hu¹,

Yang²,

Zhang³

et al. 2020

Preprint

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Background: Brucellosis is a zoonotic infectious disease caused by brucella, patients often show obvious clinical manifestation, however, many cases of asymptomatic brucella infection were reported. Previous scholars have described or screened the asymptomatic infection, but little attention has been paid to the results. This research focused on the short-term results in patients with asymptomatic brucella infectionMethods: 595 household members of shepherds in brucellosis endemic areas were included, all of them have questionnaires and laboratory tests. Based on inclusion and exclusion criteria for the cohort, 15 asymptomatic infections were included and followed-up for 18months.Results: Among 595 subjects, 34(5.7%) were asymptomatic infections, 460(77.3%) were healthy, 58patients (9.7%) were diagnosed as brucellosis, 13(2.2%) suspected cases, 19(3.2%) cured cases and 11(1.8%) unclear diagnosis. Among 15 asymptomatic infections, the median age was 34 [12, 50] years, there were 40%cases <18 years old and the male-female ratio was 1.5:1, 60% cases were farmers and herdsmen, 11(73.3%) cases had a history of possible exposure to brucella. Average follow-up time was 10.47 ± 8.47 months. A total of 7 asymptomatic infections developed into brucellosis, of which five patients turned in the first month of follow-up, one patient in the second month, and one minor case turned in the seventh month. Remaining asymptomatic infections showed negative outcomes after 7 months of follow-up, among them, SAT titer decreased in two cases, no changes in SAT titer and clinical manifestations in six cases.Conclusions: Continued exposure to brucella may be a major risk factor for asymptomatic infection turn to brucellosis.

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“…Acquired brucellosis in young infants has rarely been reported. Makis et al 8 reported a girl aged 2.5 months who became infected either by inhaling infected aerosolised particles or by direct transmission of the pathogen through minor skin abrasions or mucosal surfaces. Most of the young infants with brucellosis presented with low birth weight, failure to thrive, jaundice, hepatomegaly, splenomegaly, respiratory difficulty and general signs of sepsis (fever, vomiting).…”

Section: Discussionmentioning

confidence: 99%

Acquired Brucella bacteraemia in a young infant

et al. 2017

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An infant aged 6 weeks presented with failure to thrive since birth, fever and lethargy for 4 days. The child was fed on unpasteurised diluted goat's milk after birth. She was diagnosed to have brucellosis both by blood culture and serology. Her mother's Brucella serology was negative. She was successfully treated with injection amikacin and tablet rifampicin and had satisfactory weight gain thereafter. Acquired brucellosis should be considered in the differential diagnosis of failure to thrive in young infants.

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Brucellosis in Infant after Familial Outbreak

Cited by 6 publications

References 9 publications

Reemergence of Human and Animal Brucellosis, Bulgaria

Reemergence of Human and Animal Brucellosis, Bulgaria

Screening household members of shepherds in brucellosis endemic areas in China and reporting follow-up results of asymptomatic infections

Acquired Brucella bacteraemia in a young infant

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