Brucellosis in Guangdong Province, People’s Republic of China, 2005–2010

Chen, Jing-diao; Ke, Changwen; Deng, Xiaoling; Jiang, Shu Man; Liang, Wenjia; Ke, Bixia; Li, Baisheng; HaiLing, Tan; Liu, Meizhen

doi:10.3201/eid1905.120146

Cited by 34 publications

(40 citation statements)

References 4 publications

(4 reference statements)

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“…It is also worth noting that half of the world pig population is housed in China, where information on the prevalence of brucellosis in pigs is limited (108). However, B. suis biovar 3 infection in humans has been reported in Guangdong Province in China (109), suggesting that brucellosis has not been efficiently controlled and that it impacts on human health.…”

Section: Zoonotic Brucellosismentioning

confidence: 99%

The quest for a true One Health perspective of brucellosis

Godfroid¹,

DeBolle²,

Roop³

et al. 2014

Rev. Sci. Tech. OIE

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SummaryOne Health is an interdisciplinary collaboration that aims at mitigating risks to human health arising from microorganisms present in non-human animal species, which have the potential to be transmitted and cause disease in humans. Different degrees of scientific collaboration and sectoral integration are needed for different types of zoonotic diseases, depending on the health and associated economic gains that can be expected from a One Health approach. Indeed, mitigating zoonotic risks related to emerging diseases with pandemic potential is different from mitigating risks related to endemic zoonotic diseases like brucellosis. Likewise, management of brucellosis at the wildlife-livestock interface in wildlife conservation areas is in essence different from mitigating transmission of a given Brucella species within its preferential host species, which in turn is different from mitigating the spillover of a given Brucella species to non-preferential host species, humans included. Brucellosis economic models often oversimplify and/or wrongly assess transmission between reservoir hosts and spillover hosts. Moreover, they may not properly value non-market outcomes, such as avoidance of human disease, consumer confidence and conservation biology issues. As a result, uncertainty is such that the economic predictions of these models can be questionable. Therefore, understanding the infection biology of Brucella species is a prerequisite. This paper reviews and highlights important features of the infection biology of Brucella species and the changing epidemiology of brucellosis that need to be integrated into a true One Health perspective of brucellosis.

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Section: Zoonotic Brucellosismentioning

confidence: 99%

The quest for a true One Health perspective of brucellosis

Godfroid¹,

DeBolle²,

Roop³

et al. 2014

Rev. Sci. Tech. OIE

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“…However, underreporting of brucellosis is common worldwide because it is easily unrecognized by both patients and physicians due to its nonspecific clinical features [1–4]. The national incidence of human brucellosis in China has been dramatically increasing in recent years [15–23], reaching a historic high in 2014 with 57,222 reported cases and incidence rate of 4.2/100,000 (the population is 1367.8 million) [24]. A few high-risk counties were detected in the Inner Mongolia Autonomous Region and neighboring provinces of Shanxi, Heilongjiang, Jilin, and Xinjiang [15].…”

Section: Introductionmentioning

confidence: 99%

Epidemic characteristics, high-risk townships and space-time clusters of human brucellosis in Shanxi Province of China, 2005–2014

et al. 2016

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BackgroundBrucellosis, one of the world’s most important zoonosis, has been re-emerging in China. Shanxi Province, located in northern China, where husbandry development has been accelerated in recent years, has a rather high incidence of human brucellosis but drew little attention from the researchers. This study aimed to describe the changing epidemiology of human brucellosis in Shanxi Province from 2005 to 2014 and explore high-risk towns and space-time clusters for elucidating the necessity of decentralizing disease control resource to township level in epidemic regions, particularly in hotspot areas.MethodsWe extracted data from the Chinese National Notifiable Infectious Disease Reporting System to describe the incidence and spatiotemporal distribution of human brucellosis in Shanxi Province. Geographic information system was used to identify townships at high risk for the disease. Space-Time Scan Statistic was applied to detect the space-time clusters of human brucellosis during the past decade.ResultsFrom 2005 to 2014, a total of 50,002 cases of human brucellosis were recorded in Shanxi, with a male-to-female ratio of 3.9:1. The reported incidence rate increased dramatically from 7.0/100,000 in 2005 to 23.5/100,000 in 2014, with an average annual increase of 14.5%. There were still 33.8% cases delaying diagnosis in 2014. The proportion of the affected towns increased from 31.5% in 2005 to 82.5% in 2014. High-risk towns spread from the north to the center and then south of Shanxi Province, which were basins and adjacent highlands suitable for livestock cultivation. During the past decade, there were 55 space-time clusters of human brucellosis detected in high risk towns; the clusters could happen in any season. Some clusters’ location maintained stable over time.ConclusionsDuring the last decade, Shanxi province’s human brucellosis epidemic had been aggravated and high-risk areas concentrated in some towns located in basins and adjacent highlands. Space-time clusters existed and some located steadily over time. Quite a few cases still missed timely diagnosis. Greater resources should be allocated and decentralized to mitigate the momentum of rise and improve the accessibility of prompt diagnosis treatment in the high-risk townships.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-2086-x) contains supplementary material, which is available to authorized users.

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“…Although brucellosis has been eradicated from many industrialized countries, new foci of disease continually appear (35). The excellent diagnostic performance of the OAg-AcrA antigen for diagnosis of brucellosis in different species and the fact that the recombinant glycoprotein can be produced in large homogeneous batches in a standardized way make it an ideal candidate for further validation as a universal antigen for diagnosis of smooth brucellosis.…”

Section: Discussionmentioning

confidence: 99%

A Bacterial Glycoengineered Antigen for Improved Serodiagnosis of Porcine Brucellosis

et al. 2016

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dBrucellosis is a highly zoonotic disease that affects animals and human beings. Brucella suis is the etiological agent of porcine brucellosis and one of the major human brucellosis pathogens. Laboratory diagnosis of porcine brucellosis mainly relies on serological tests, and it has been widely demonstrated that serological assays based on the detection of anti O-polysaccharide antibodies are the most sensitive tests. Here, we validate a recombinant glycoprotein antigen, an N-formylperosamine O-polysaccharide-protein conjugate (OAg-AcrA), for diagnosis of porcine brucellosis. An indirect immunoassay based on the detection of anti-O-polysaccharide IgG antibodies was developed coupling OAg-AcrA to enzyme-linked immunosorbent assay plates (glycoiELISA). To validate the assay, 563 serum samples obtained from experimentally infected and immunized pigs, as well as animals naturally infected with B. suis biovar 1 or 2, were tested. A receiver operating characteristic (ROC) analysis was performed, and based on this analysis, the optimum cutoff value was 0.56 (relative reactivity), which resulted in a diagnostic sensitivity and specificity of 100% and 99.7%, respectively. A cutoff value of 0.78 resulted in a test sensitivity of 98.4% and a test specificity of 100%. Overall, our results demonstrate that the glyco-iELISA is highly accurate for diagnosis of porcine brucellosis, improving the diagnostic performance of current serological tests. The recombinant glycoprotein OAg-AcrA can be produced in large homogeneous batches in a standardized way, making it an ideal candidate for further validation as a universal antigen for diagnosis of "smooth" brucellosis in animals and humans. B rucella spp. are Gram-negative facultative intracellular bacteria responsible for brucellosis in humans and animals. Animal brucellosis has a major economic impact because the infection causes abortions and stillbirths and reduces fertility in herds, while brucellosis in humans is a debilitating disease characterized by fever, sweating, and pain (1, 2). Brucella suis is the etiological agent of porcine brucellosis and one of the main human brucellosis pathogens, together with Brucella melitensis and Brucella abortus. There are five biovars of B. suis, with biovars 1, 2, and 3 being responsible for porcine brucellosis (3). B. suis biovars 1 and 3, endemic in Asia and America, are highly zoonotic and cause serious reproductive problems in pigs (infertility, abortion, and orchitis) and a serious disease in humans. Biovar 2 is restricted to Europe, where it represents an emerging problem with a high economic impact in pig farms and is less pathogenic for humans.In the absence of an effective porcine brucellosis vaccine, control of the disease in pigs depends exclusively on detection and slaughter of infected animals. The gold standard method for confirmation of the infection is isolation of the pathogen; however, the slow growth of brucellae in primary cultures (up to 7 days), the risk involved in their handling, and the poor sensitivity of the meth...

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Brucellosis in Guangdong Province, People’s Republic of China, 2005–2010

Cited by 34 publications

References 4 publications

The quest for a true One Health perspective of brucellosis

The quest for a true One Health perspective of brucellosis

Epidemic characteristics, high-risk townships and space-time clusters of human brucellosis in Shanxi Province of China, 2005–2014

A Bacterial Glycoengineered Antigen for Improved Serodiagnosis of Porcine Brucellosis

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