Brucellosis in Adults and Children: A 10-Year Case Series at Two Large Academic Hospitals in Houston, Texas

Serpa, José A.; Knights, Sheena; Farmakiotis, Dimitrios; Campbell, Judith R.

doi:10.14423/smj.0000000000000810

Cited by 10 publications

(7 citation statements)

References 19 publications

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“…This leads to the formation of an infectious granuloma that might have been responsible for the splenomegaly observed in about a third of the patients in this study. The findings also showed that lymphadenopathy and hepatomegaly were common, corroborating with previous research [6].…”

Section: Discussionsupporting

confidence: 91%

A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults

Chen

et al. 2021

J Infect Dev Ctries

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Introduction: Brucellosis is a zoonosis with a wide spectrum of clinical manifestations. However, it is still unclear whether the clinical manifestations in children are significantly different from those in adults. Methodology: Patients with brucellosis and treated at the General Hospital of Ningxia Medical University between 2009 and 2019 were divided into two groups; children (88) and adults (354). Thereafter, the records of the two groups were analyzed retrospectively. Results: The findings showed that: 1. School-age children, young and middle-aged individuals were more likely to suffer from brucellosis and most were male; 2. Fever and arthralgia were the most common manifestations in the two groups. In addition, fatigue and low back pain were rare in children although fever and lymphadenopathy were more common in this group. However, hepatomegaly and splenomegaly were common in both groups; 3. The most common complication was osteoarthritis and peripheral arthritis occurred more frequently in children. On the other hand, spondylitis was the most common in adults (this particularly involved the lumbar and sacral vertebrae); 4. An increase in the erythrocyte sedimentation rate, levels of the C-reactive protein and liver enzymes was common in both two groups; 5. There was no significant difference in the positive rate of the standard agglutination test between children (96.59%) and adults (95.20%). However, the positive rate of blood culture was higher in children (65.85%) than in adults (51.00%). Conclusions: Brucellosis causes damage to multiple systems and differences in clinical characteristics were found between children and adults.

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Section: Discussionsupporting

confidence: 91%

A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults

Chen

et al. 2021

J Infect Dev Ctries

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“…Hematological complications such as anemia, leukopenia and thrombocytopenia are common in the course of brucellosis, and pancytopenia may be observed less frequently [3,5]. These hematological complications are more common in acute brucellosis cases (as opposed to relapse cases) and in patients with growth in blood culture [28]. These complications are typically mild and resolve promptly with antimicrobial therapy.…”

Section: Discussionmentioning

confidence: 99%

Çocukluk çağında bruselloz: 37 olgunun retrospektif değerlendirilmesi ve literatürün gözden geçirilmesi

ÇELİK

KAAN

2022

Family Practice and Palliative Care

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Introduction: The aim of this study is to evaluate the demographic, clinical and laboratory characteristics and treatment results of pediatric patients followed up with the diagnosis of brucellosis in our clinic.Methods: Patients who were followed up with the diagnosis of brucellosis in Kayseri Training and Research Hospital, Pediatric Infectious Diseases Clinic between October 2016 and December 2018 were retrospectively analyzed.Results: A total of 37 patients, 26 (70.3%) male, were included in the study. The mean age of the patients whose ages ranged from 1 to 17 years was 9.3±4.3 years. Unpasteurized milk and/or dairy products were consumed in 86.5% of the patients and 48.6% had a family history of brucellosis. Joint pain (75.7%) was the most common presenting complaint. In the laboratory evaluation, 8.1% of the patients had leukopenia, 2.7% had thrombocytopenia and 21.4% had ALT elevation. Doxycycline plus rifampicin (43.2%) was the most commonly preferred treatment regimen. Addition of aminoglycoside to initial therapy in hospitalized patients was statistically higher than in outpatients (81.2% vs. 23.8%) (p=0.001). During the follow-up, relapse developed in a total of 4 (10.8%) patients, 3 of whom were outpatients. There was no statistical relationship between the initial treatment regimen and relapse (p=0.418).Conclusion: In conclusion, brucellosis should be kept in mind in terms of differential diagnosis in patients who present with joint pain in our country and who have cytopenia and/or isolated aminotransferase elevation in their investigations.Keywords: Child, Brucellosis, Relapse

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“…The cases reported in Sweden were mostly due to the travelers arriving from the countries where brucellosis is endemic. In the USA, brucellosis is found commonly in immigrant families, especially in border states such as Texas (Serpa et al, 2018). However, B. abortus has not been reported in Western and Northern Europe, Canada, Japan, Israel, Australia and New Zealand (Adetunji et al, 2019).…”

Section: Epidemiologymentioning

confidence: 99%

An overview of human brucellosis: a neglected zoonotic disease in livestock

Priyantha¹

2021

Sri Lanka Vet. J.

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Brucellosis is a neglected, zoonotic bacterial disease in humans with over 500, 000 new cases reported each year worldwide. Brucella abortus, B. melitensis, B. suis and B. canis have been detected in humans as causative agents of this zoonotic infection. The incidence of brucellosis varies greatly with several factors such as socio-economic status, association with livestock, occupation and food safety practices. Brucellosis is an endemic disease in Sri Lanka and only a few cases have been reported in humans in recent years. Human brucellosis is a common disease in the Mediterranean region, Middle East, Asia, South and Central America and Africa. The organism infects multiple hosts. Multiple routes of infection have been described for humans, the oral route being the most common. The common clinical signs in humans are undulant fever, fatigue, headache, chills and myalgia. Other signs and symptoms such as arthralgia, orchitis/epididymitis, acute renal failure, endocarditis, splenic abscess, spondylitis, arthritis, encephalitis hepatitis, osteoarticular manifestations, meningitis, and respiratory and cardiac complications also had been reported. Bacteriological culture, serology and nucleic acid amplification assays have been used as the basic diagnostic methods of brucellosis. The prevention strategy of human brucellosis recommended by the World Health Organization (WHO) mainly consists of creating public awareness, improving hygienic practices in livestock farms and slaughterhouses, promoting the consumption of pasteurized milk, consumption of cooked meat, adhering to hygienic practices during laboratory handling of the organism and proper handling of companion animals. The recommended prevention and control methods of brucellosis in animals include culling of infected animals, vaccination and restriction of the movement of serologically positive animals. In conclusion, further emphasis must be given to improving diagnostic testing and raising awareness of brucellosis and its zoonotic implications among humans.

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Brucellosis in Adults and Children: A 10-Year Case Series at Two Large Academic Hospitals in Houston, Texas

Cited by 10 publications

References 19 publications

A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults

A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults

Çocukluk çağında bruselloz: 37 olgunun retrospektif değerlendirilmesi ve literatürün gözden geçirilmesi

An overview of human brucellosis: a neglected zoonotic disease in livestock

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