Brucellosis

Blasco, J.M.; Moreno, Edgardo; Moriyón, Ignacio

doi:10.1002/9781119506287.ch22

Cited by 9 publications

(18 citation statements)

References 91 publications

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“…In the example of brucellosis control in livestock, when the disease prevalence is high, control relies on vaccination. As prevalence decreases, test-and-removal of seropositive adults can be considered [44,45]. In this respect, the detection of infected herds or flocks and assessment of the disease prevalence are crucial.…”

Section: Discussionmentioning

confidence: 99%

Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health

Qiu,

Guitian,

Webster

et al. 2023

Phil. Trans. R. Soc. B

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Zoonotic diseases (zoonoses) originating from domestic animals pose a significant risk to people's health and livelihoods, in addition to jeopardizing animal health and production. Effective surveillance of endemic zoonoses at the animal level is crucial to assessing the disease burden and risk, and providing early warning to prevent epidemics in animals and spillover to humans. Here we aimed to prioritize and characterize zoonoses for which surveillance in domestic animals is important to prevent human infections at a global scale. A multi-criteria qualitative approach was used, where disease-specific information was obtained across literature of the leading international health organizations. Thirty-two zoonoses were prioritized, all of which have multi-regional spread, cause unexceptional human infections and have domestic animal hosts as important sources or sentinels of zoonotic infections. Most diseases involve multiple animal hosts and/or modes of zoonotic transmission, where a lack of specific clinical signs in animals further complicates surveillance. We discuss the challenges of animal health surveillance in endemic and resource-limited settings, as well as potential avenues for improvement such as the multi-disease, multi-sectoral and digital surveillance approaches. Our study will support global capacity-building efforts to strengthen the surveillance and control of endemic zoonoses at their animal sources. This article is part of the theme issue ‘Challenges and opportunities in the fight against neglected tropical diseases: a decade from the London Declaration on NTDs’.

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Section: Discussionmentioning

confidence: 99%

Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health

Qiu,

Guitian,

Webster

et al. 2023

Phil. Trans. R. Soc. B

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“…The requirements for an optimal Brucella vaccination have remained unchanged since they were first established many years ago. Such a vaccine should be safe and effective, does not enhance antibodies interfering with serodiagnosis, cannot be transmitted to humans or other animals (including no contamination of milk, edible organs, dairy products, or meat), be stable in vitro and in vivo , be easily cultivable for large-scale production, and be supplemented with markers to be differentiated from the field isolates ( 29 ).…”

Section: Immunitymentioning

confidence: 99%

“…People can get the infection by contact with infected animals during their usual work (occupational) as in the case of veterinarians, abattoir workers, and livestock keepers. Consumption of unpasteurized milk is also regarded as a common source of infection ( 29 ). Although pasteurizing milk kills Brucella and prevents infection in humans, it is not commonly performed in some communities with a widespread lack of public awareness about the danger of drinking raw milk ( 30 ).…”

Section: Introductionmentioning

confidence: 99%

Brucellae as resilient intracellular pathogens: epidemiology, host–pathogen interaction, recent genomics and proteomics approaches, and future perspectives

Dawood,

Elrashedy,

Nayel

et al. 2023

Front. Vet. Sci.

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Brucellosis is considered one of the most hazardous zoonotic diseases all over the world. It causes formidable economic losses in developed and developing countries. Despite the significant attempts to get rid of Brucella pathogens in many parts of the world, the disease continues to spread widely. Recently, many attempts proved to be effective for the prevention and control of highly contagious bovine brucellosis, which could be followed by others to achieve a prosperous future without rampant Brucella pathogens. In this study, the updated view for worldwide Brucella distribution, possible predisposing factors for emerging Brucella pathogens, immune response and different types of Brucella vaccines, genomics and proteomics approaches incorporated recently in the field of brucellosis, and future perspectives for prevention and control of bovine brucellosis have been discussed comprehensively. So, the current study will be used as a guide for researchers in planning their future work, which will pave the way for a new world without these highly contagious pathogens that have been infecting and threatening the health of humans and terrestrial animals.

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“…Brucellosis is a zoonotic disease caused by small intracellular aerobic Gram-negative bacilli bacteria called Brucella [ 1 ]. It is transmitted to humans by direct contact with an infected animal or ingestion of unpasteurized milk derivatives [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The association between acute brucellosis with a Guillain–Barré syndrome-like presentation: a case report

2023

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Background Brucellosis is a zoonotic disease caused by Gram-negative bacteria. It has variable manifestations (gastrointestinal, hepatobiliary, skeletal). Neurobrucellosis may develop at any stage of the disease (acute, subacute, and chronic phases) and affects the central and peripheral nervous systems. Acute peripheral neuropathy mimicking Guillain–Barré syndrome caused by brucellosis is rarely reported: only four cases in children were found in the literature review. Case presentation We report a case of a 4-year-old Syrian boy who presented with fever, weakness of lower limbs, backache, and fatigue. The patient lived in a brucellosis endemic area. A physical examination including a neurological examination showed mild paresthesia and muscle weakness. He had a stiff neck with Kernig’s sign with an absence of deep tendon reflexes in the lower extremities. Proprioception in the lower extremities was impaired, but he did not have any sensory problems. Abdominal cutaneous reflexes were absent. Brucellosis and Guillain–Barré syndrome were found in laboratory investigations and on electroneurogram (ENG). The patient was treated with sulfamethoxazole + trimethoprim, rifampicin, gentamicin, and dexamethasone, with an improvement. Conclusion This case demonstrates a rare case of brucellosis neurologic manifestation. Brucellosis should be kept in mind in all patients with acute paralysis, especially in those who live in endemic areas.

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Brucellosis

Cited by 9 publications

References 91 publications

Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health

Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health

Brucellae as resilient intracellular pathogens: epidemiology, host–pathogen interaction, recent genomics and proteomics approaches, and future perspectives

The association between acute brucellosis with a Guillain–Barré syndrome-like presentation: a case report

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