Brucellar uveitis: intraocular fluids and biopsy studies

Rolando, I.; Vilchez, Gustavo; Olarte, Liset; Lluncor, Marina; Carrillo, Carlos; Paris, Mark; Guerra, Humberto; Gotuzzo, Eduardo

doi:10.1016/j.ijid.2008.12.004

Cited by 16 publications

(12 citation statements)

References 30 publications

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“…Two explanations may be there for the pathogenesis of ophthalmic brucellosis-direct invasion of Brucella and immune complex dependent pathogenesis [6,8,11]. In 2008, Rolando et al reported about two different manifestations of brucellosis, ophthalmologic and neuro-ophthalmologic types [7].…”

Section: Discussionmentioning

confidence: 99%

“…In 1953, Puig Solanes et al identified 60 patients with ophthalmic complications of brucellosis and in them 48 patients had neuro-ophthalmic involvement [8]. In most of the studies, it has been found that uveitis is the most common ocular manifestation of brucellosis and that posterior uveitis is the most common form of uveitis [7,8,11,12]. Ocular manifestations are mainly seen during the chronic phase of the disease [7,8,[13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

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Brucellar Uveitis in Eastern India

Sen¹,

Banerjee²,

Dutta

et al. 2016

Asian J Pharm Clin Res

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Objective: Brucellosis, one of the major zoonotic diseases, still remains an uncontrolled problem, in regions of high endemicity. Ophthalmic brucellosis is not studied and overlooked in most developing countries. Considering the severe outcome of undiagnosed ophthalmic brucellosis, in this paper, we made attempts to find out whether this disease still remains a health problem in a South East Asian developing country, where the study of this disease is largely neglected.Methods: This study was carried out over a 1-year period from January 2015 to December 2015. Blood samples were collected from clinically confirmed cases of uveitis, and they were subjected to five serological and one genus specific molecular investigations for the detection of Brucella infection.Results: Out of 20 uveitis cases, 4 (20%) cases confirmed as brucellar uveitis, by serological tests followed by polymerase chain reaction confirmation. After treatment of brucellosis, all the four patients were recovered uneventfully. Conclusion:Brucella infection involving the eye is still a significant problem in South East Asian countries; hence in all uveitis cases in this reason brucellosis should be excluded by available laboratory tests.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Brucellar Uveitis in Eastern India

Sen¹,

Banerjee²,

Dutta

et al. 2016

Asian J Pharm Clin Res

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“…Puig Solanes et al 11 found ocular symptoms in 60 (14.5%) of 413 patients. In the aetiological classification of 12 patients with ocular brucellosis, Rolando et al 12 reported that 6 (50%) had panuveitis, 2 (16.7%) had posterior uveitis, 3 (25%) had intermediate uveitis and 1 (8.3%) had anterior uveitis. In another study of 52 patients with ocular brucellosis, 21 (40%) had posterior uveitis, 9 (17%) had panuveitis, and 8 (15%) had anterior and intermediate uveitis 13.…”

Section: Discussionmentioning

confidence: 99%

Bilateral sacroiliitis and uveitis comorbidity: brucellosis? Ankylosing spondylitis?

Akyol

Aslan²,

Özgen

et al. 2015

BMJ Case Reports

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We present a rare case of a comorbidity of sacroiliitis and brucellosis infection. A 28-year-old woman received irregular medication due to ongoing backache and hip pain for 5 years. The patient presented to our hospital for evaluation of visual loss and was diagnosed with uveitis. Sacroiliac MRI was performed to investigate the inflammatory backache and hip pain, and the aetiology of the uveitis, revealing the presence of sacroiliitis. The patient's blood test results were as follows: positive brucellosis Rose Bengal test and positive tube agglutination test with a titre of 1/640. The patient was treated with doxycycline and rifampicin for 8 weeks for the brucellosis infection, and with acemetacin for the ankylosing spondylitis. The patient's back and hip pain decreased significantly 8 weeks later; however, the uveitis was not controlled by the treatment. Therefore, anti-tumour necrosis factor (infliximab) treatment was started.

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“…One is mediated by the presence of B. melitensis in the acute phase of the disease and the second is mediated by specific antibodies and immune complexes present in the chronic phase. Rolando et al [28] performed aqueous paracentesis in two ocular brucellosis cases and were able to isolate the organism in only one patient after 24 days of incubation. However, they detected positive intraocular agglutinations in all patients, suggesting the presence of specific immunoglobulins in the eye.…”

Section: Recovery Recoverymentioning

confidence: 99%