Brucellar spondylo-discitis with rapidly progressive spinal epidural abscess presenting with sciatica

Yüksel, Kasım Zafer; Şenoğlu, Mehmet; Yüksel, Mürvet; Gül, Mustafa

doi:10.1038/sj.sc.3101938

Cited by 17 publications

(15 citation statements)

References 22 publications

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“…number of diseased vertebral body, focal distribution), clinical manifestations, imaging features (X-ray, CT, MR) and the clinical specific serological examination such as Serum tube agglutination (SAT), rose bengal plate agglutination test (RBP), enzyme-linked immunosorbent assay (ELISA) and so on, which were consistent with the diagnostic criteria of brucellosis published by Endemic Disease Prevention and Cure Bureau of Ministry of Public Health [11,12,15].…”

Section: Introductionsupporting

confidence: 50%

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The Assessment of the Clinical Effect of the Drug Compatibility and Course of Treatment to the Brucellar Spondylitis

Yang¹,

We²,

Meng³

et al. 2013

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Objective: To evaluate five drug treatment regimens in the treatment of Brucella spondylitis. Methods: Patients with clinical symptoms compatible and diagnostic test consistent with Brucella spondylitis were randomly assigned to five drug treatment regimens. Results: Combination therapy with doxycycline, rifampin and sulfamethoxazole for 56 consecutive days showed the highest cure rate of 20% after a single course and of 85% after a double course with affectivity rates of 55% and 95%. Cure rate and affectivity rate was significant better (P < 0.05) than for patients receiving doxycycline, rifampin and streptomycin for the same period and regimens containing doxycycline were significant better than regimens without this drug. Conclusion: Combination therapy of doxycycline, rifampin and sulfamethoxazole for 8 weeks using one or two full courses should be recommended for Brucella spondylitis.

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Section: Introductionsupporting

confidence: 50%

“…Choosing the correct drugs and course of treatment is benefit to the cure of diseased region, relief of the pain and decrease of complications [9][10][11][12][15][16][17][18]. The principle instituted by the six alliance bulletin of WHO is using Tetracycline and Streptomycin or using the same kind of drugs as alternative medicine.…”

Section: Discussionmentioning

confidence: 99%

The Assessment of the Clinical Effect of the Drug Compatibility and Course of Treatment to the Brucellar Spondylitis

Yang¹,

We²,

Meng³

et al. 2013

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“…Patients may initially present with sciatica and may be misdiagnosed with lumbar disc herniation owing to non-specific neurological and radiological findings. The delay in diagnosis may lead to rapid progression of the disease and complications [31,32].…”

Section: Brucellosismentioning

confidence: 99%

Non-pyogenic infections of the spine

Skaf

Kanafani

Araj

et al. 2010

International Journal of Antimicrobial Agents

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“…Combination of both medical and surgical treatments is necessary to alleviate the disease 16 . However, conservative treatment with close observation may be sufficient in selected cases, particularly in the elderly 6 .…”

Section: Discussionmentioning

confidence: 99%

Lumbar epidural abscess caused by brucella species: report of two cases

et al. 2009

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SummarySpinal epidural abscess due to Brucella species is usually associated with spondylodiscitis. Urgent surgical decompression should be performed in cases with moderate to severe neurological deficits particularly if progressive. We report clinical features of two cases operated for lumbar epidural abscess caused by Brucella species. Early surgical decompression combined with medical treatment could decrease progression of neurological findings or the severity of complications. Iatrogenic dural tear at the operation should be repaired immediately with fine sutures and fibrin tissue glue to prevent further innoculation into the cerebrospinal axis. These cases should be cautiously followed for any recurrence or neurobrucellosis.KEY WORDS: Epidural abscess. Brucellosis. Brucella spondylitis. Lumbar region. Surgery. Dural tear Absceso epidural lumbar causado por brucella: descripción de dos casos Resumen Los abscesos epidurales espinales debidos a Brucella se asocian habitualmente a espondilodiscitis. La descompresión quirúrgica urgente debe ser realizada en casos con déficit neurológico moderado o grave particularmente si este es progresivo. Describimos los aspectos clínicos de dos casos operados por abscesos epidurales causados por Brucella. El tratamiento quirúrgico temprano asociado con tratamiento médico puede disminuir la progresión de la sintomatología neurológica y la gravedad de las complicaciones. La aparición de desgarros durales durante la cirugía debe ser reparada de forma inmediata con sutura o pegamentos de fibrina para prevenir la inoculación dentro del neuroeje. Estos casos deben ser seguidos de forma cuidadosa para evitar la recurrencia de la neurobrucelosis.PALABRAS CLAVE: Absceso epidural. Brucelosis. Espondilitis por brucella. Región lumbar. Cirugía. Desgarro dural.

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Brucellar spondylo-discitis with rapidly progressive spinal epidural abscess presenting with sciatica

Cited by 17 publications

References 22 publications

The Assessment of the Clinical Effect of the Drug Compatibility and Course of Treatment to the Brucellar Spondylitis

The Assessment of the Clinical Effect of the Drug Compatibility and Course of Treatment to the Brucellar Spondylitis

Non-pyogenic infections of the spine

Lumbar epidural abscess caused by brucella species: report of two cases

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