Brucellar Spondylitis

Lee, Hong Jae; Hur, Jin Woo; Lee, Jong Won; Lee, Sang Rok

doi:10.3340/jkns.2008.44.4.277

Cited by 17 publications

(17 citation statements)

References 13 publications

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“…Positive bacterial cultures were obtained for only 11 of the 16 patients with confirmed brucellar spondylitis. Therefore, we recommend that brucellosis is diagnosed according to clinical manifestations and the isolation of Brucella species from blood or bone marrow cultures [ 11 , 12 ]. In the absence of bacteriologic confirmation, positive serology for brucella (titer over 1 : 160 in a standard tube agglutination test or a 4-fold increase in the brucella-antibody titer) is needed for definite diagnosis [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

The Evaluation of the Clinical, Laboratory, and Radiological Findings of 16 Cases of Brucellar Spondylitis

Yang

Chen

et al. 2016

BioMed Research International

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Objective. To evaluate the clinical, laboratory, and radiological presentation of 16 cases of brucellar spondylitis. Methods. The clinical manifestations, laboratory tests, and imaging findings of 16 patients (aged from 24 to 66 years) with brucellar spondylitis treated between September 2012 and September 2014 at the Second Affiliated Hospital of Xi'an Jiaotong University (Xi'an, China) were retrospectively analyzed. Results. Clinical manifestations included high fever, severe pain, sweating, and fatigue. One patient had epididymitis, and two showed clear signs of spinal nerve damage. Laboratory tests showed elevated erythrocyte sedimentation rate (ESR) and C-reactive protein content. Serum brucella agglutination tests were positive, and 11 brucella blood cultures were positive. Imaging manifestations mainly consisted of abnormal signals in the intervertebral space or abnormal signals in the adjacent vertebral bodies (16/16, 100%) in magnetic resonance imaging (MRI), disc space narrowing (14/16, 88%) in X-ray and MRI, or bone destruction and sclerosis around the damaged zone (13/16, 81%) in computed tomography, with rare cases of psoas abscess (2/16, 13%) and sequestrum (1/16, 6%). Conclusion. Since brucellar spondylitis exhibited characteristic clinical and imaging manifestations, it could be diagnosed with specific laboratory tests. Early MRI examination of suspected cases could improve rapid diagnosis.

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Section: Discussionmentioning

confidence: 99%

The Evaluation of the Clinical, Laboratory, and Radiological Findings of 16 Cases of Brucellar Spondylitis

Yang

Chen

et al. 2016

BioMed Research International

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“…9 There has been, however, much dispute over the mechanism as to whether it is an S N 2 or an S A N process; Rogne and Lee favor an S N 2 3e,10 whereas Ciuffarin favors an S A N 3g mechanism. Also, the mechanism of solvolysis of 2-propanesulfonyl chloride (III) has been described 11 as controversial, and, indeed, both S N 1 [12][13][14] and S N 2 15,16 mechanism have been proposed.…”

Section: Resultsmentioning

confidence: 99%

Application of the Extended Grunwald-Winstein Equation to the Solvolyses of Phenyl Methanesulfonyl Chloride in Aqueous Binary Mixtures

Koh

Kang²

2011

Bulletin of the Korean Chemical Society

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This report shows the rates of solvolyses for phenyl methanesulfonyl chloride (C 6 H 5 CH 2 SO 2 Cl, I) in ethanol, methanol, and aqueous binary mixtures incorporating ethanol, methanol, acetone, 2,2,2-trifluroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) are reported. Three representative solvents, studies were made at several temperatures and activation parameters were determined. The thirty kinds of solvents gave a reasonably precise extended Grunwald-Winstein plot, coefficient (R) of 0.954. The sensitivity values (l = 0.61 and m = 0.34, l/m = 1.8) of phenyl methanesulfonyl chloride (I) were smaller than those obtained for benzenesulfonyl chloride (C 6 H 5 SO 2 Cl, II; l = 1.01 and m = 0.61) and 2-propanesulfonyl chloride ((CH 3 ) 2 CHSO 2 Cl, III; l = 1.28 and m = 0.64). As with the two previously studied solvolyses, an S N 2 pathway with somewhat ionization reaction is proposed for the solvolyses of I. The activation parameters, ΔH ≠ and ΔS ≠ , were determined and they are also in line with values expected for a bimolecular reaction mechanism. The kinetic solvent isotope effect of 2.34 in CH 3 OH/CH 3 OD is in accord with a bimolecular mechanism, probably assisted by general-base catalysis.

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“…Bruselloz, Brucella cinsi fakültatif hücre içi bakterilerin neden olduğu ve enfekte hayvanlarla doğrudan temas yoluyla veya pastörize edilmemiş süt ve süt ürünlerinin tüketimi ile bulaşan zoonotik bir enfeksiyondur (1)(2)(3). Brusellozis, Türkiye dahil olmak üzere çoğu Akdeniz ülkeleri, Ortadoğu, Orta ve Güney Amerika'da hala önemli bir halk sağlığı problemidir (4).…”

Section: Introductionunclassified

Endemik Bölgede Brucella Spondilodiskitis: 18 Hastanın Retrospektif Olarak Gözden Geçirilmesi

Sözen¹

2015

Konuralp Tıp Dergisi

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Brucellar Spondylodiscitis in an Endemic Area: Retrospective Review of 18 PatientsABSTRACT Aim: Osteoarticuler involvement is one of the most common complications of brucellosis and incidence is 10-85%. The major clinical manifestation of brucellar osteoarticuler involvement is spondylodiscitis. Our aim was to evaluate the brucellar spondylodiscitis. Method: Spondylodiscitis cases among patients diagnosed with brucellosis at Isparta Government Hospital between January 2005 and August 2011 were included in the study. Clinical and laboratory findings were analyzed retrospectively Results: The total number of brucellar spondylodiscitis was 18 out of 126 patients (14%). Lumbar and lumbosacral involvement was the most common location of brucellar lesions. All patients had lumbar pain and abnormal MRI findings. The average length of antibiotic therapy was 17.1 weeks Conclusion: Spondylodiscitis is an important complication of brucellosis. Brucellar spondylodiscitis, the clinical and laboratory findings cannot be distinguished from classic Brucellosis. Spondylodiscitis, the 6-week treatment period with a recurrence is a major problem. It is usually seen more frequently in elderly patients. Therefore, the middle aged with low back pain in patients with brucellosis necessarily MRI imaging should be performed. The duration of treatment according to the patient's clinical and laboratory findings should be regulated as at least 12 weeks.

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Brucellar Spondylitis

Cited by 17 publications

References 13 publications

The Evaluation of the Clinical, Laboratory, and Radiological Findings of 16 Cases of Brucellar Spondylitis

The Evaluation of the Clinical, Laboratory, and Radiological Findings of 16 Cases of Brucellar Spondylitis

Application of the Extended Grunwald-Winstein Equation to the Solvolyses of Phenyl Methanesulfonyl Chloride in Aqueous Binary Mixtures

Endemik Bölgede Brucella Spondilodiskitis: 18 Hastanın Retrospektif Olarak Gözden Geçirilmesi

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