Brucella suis strain 2 vaccine is safe and protective against heterologous Brucella spp. infections

Zhu, Li; Feng, Yu; Zhang, Ge; Jiang, Hui; Zhang, Zhen; Wang, Nan; Ding, Jiabo; Suo, Xun

doi:10.1016/j.vaccine.2015.09.116

Cited by 42 publications

(41 citation statements)

References 28 publications

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“…RB51 is widely used in the prevention and control of cow brucellosis in North America (Jing, Yan, & Fan, 2016), and Rev‐1 is considered to be the most effective vaccine against B. melitensis infection. In China, the B. suis S2 vaccine has been widely used to fight brucellosis, accounting for 95% of the market share (Zhu et al, 2016). Therefore, in the model we simulated the ability of those three vaccines against Brucella infection under current brucellosis epidemic conditions in China.…”

Section: Resultsmentioning

confidence: 99%

An estimate of the incidence and quantitative risk assessment of human brucellosis in mainland China

Peng

Zhou

Guan

et al. 2020

Transbound Emerg Dis

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Two epidemiological models were applied to simulate whether animals with latent infections were contagious and calculate the outcomes of people that contracting brucellosis by all possible transmission routes under control measures implemented by the Chinese government. The health and economic burden of brucellosis overall presented an increasing trend from 2004 to 2017. Scenarios from epidemiological models showed that a larger scale of vaccine coverage would contribute to fewer infections in livestock and humans. S2 vaccine, the disinfection of the environment and the protection of the susceptible animals and humans could effectively reverse the trend of increasing brucellosis and reduce the incidence rates of brucellosis in humans to curb the epidemic of brucellosis in China.

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Section: Resultsmentioning

confidence: 99%

An estimate of the incidence and quantitative risk assessment of human brucellosis in mainland China

Peng

Zhou

Guan

et al. 2020

Transbound Emerg Dis

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“…Brucella specific IgG was detected in vaccinated mice, and produced IFN-γ and TNF-α conferring protection in mice from a virulent challenge by B. melitensis M28, B. abortus 2308 and B. suis S1330. Adverse effects, such as clinical signs or tissue damage were not described in vaccinated animals [72].…”

Section: The Vaccinologymentioning

confidence: 98%

New Scenarios for Brucella suis and Brucella melitensis

Samartino

Arregui

Martino³

2017

Curr Clin Micro Rpt

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Purpose of Review We pretend to highlight the most important advances reached in the last few years in the biology of Brucella suis and Brucella melitensis and focus attention on new tools for the comprehension, prevention and control of these zoonotic agents. Recent Findings Important progress lately done in the field of pathogenesis is presented here. This involves current studies on proteins involved in the survival and antigenic structure of Brucella, as well as the findings of how Brucella has achieved modifications in order to adapt, replicate, survive and modulate the host´s immune system, improve the knowledge of the performance of these bacteria. Summary Consequently, better approaches for vaccinology and diagnostic techniques are developed. Relevant epidemiological issues based on changes in the highly conserved genome of these bacteria will be valuable tools to describe outbreaks and disease status, along with risk factors that would otherwise be difficult to analyze.

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“…IFN-γ is a significant cytokine that plays a crucial role in the host immune response. Previous studies demonstrated that the number of CD4 + cells and the expression of IFN-γ increased in the early stages of B. abortus infection [7][8]. Interestingly, the level of CD4, CD8 and CD21 in the blood of cattle increased when animals received the Brucella S19 vaccine and were stimulated by the Brucella 2308 antigen.…”

Section: Introductionmentioning

confidence: 93%

“…Interestingly, the level of CD4, CD8 and CD21 in the blood of cattle increased when animals received the Brucella S19 vaccine and were stimulated by the Brucella 2308 antigen. Meanwhile, the IFN-γ expression mediated by CD4 was dramatically increased [7,8].…”

Section: Introductionmentioning

confidence: 99%

Development of an interferon-γ release assay (IGRA) for detection of Brucella abortus and clinical diagnosis of brucellosis

Feng

Zhu

Peng

et al. 2017

J Infect Dev Ctries

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Introduction: Brucellosis, caused by Brucella abortus (B. abortus), is an important zoonosis posing a great risk to both livestock and humans. Currently, most assays for clinical diagnosis of brucellosis have been developed based on serological principles; however, these assays have a number of limitations and disadvantages. Methodology: To address this concern, the aim of this study was to develop a gamma interferon (IFN-γ) release assay (IGRA) for the diagnosis of brucellosis. Towards this end, the stimulating effect induced by different somatic antigens of B. abortus on the secretion of IFN-γ was evaluated. Results: The best antigen candidate, B. abortus strain 2308, able to induce high levels of IFN-γ expression in peripheral blood (PB) cells from cattle, was used for the development of the IGRA. The optimal concentration for stimulation was determined as 1.0×107 CFU/mL. This study demonstrated that IFN-γ was detectable on day 5 post infection (p.i.) and peaked on day 14 p.i.. Finally, the IGRA developed was used for detection of B. abortus in clinical samples, and a higher level of IFN-γ was detected in Brucella-infected samples compared to vaccination samples and negative controls. Conclusions: The optimal somatic antigen for B. abortus was identified and used to establish a robust IGRA. The IGRA developed is suitable for clinical diagnosis of brucellosis, especially in the early stages of infection.

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Brucella suis strain 2 vaccine is safe and protective against heterologous Brucella spp. infections

Cited by 42 publications

References 28 publications

An estimate of the incidence and quantitative risk assessment of human brucellosis in mainland China

An estimate of the incidence and quantitative risk assessment of human brucellosis in mainland China

New Scenarios for Brucella suis and Brucella melitensis

Development of an interferon-γ release assay (IGRA) for detection of Brucella abortus and clinical diagnosis of brucellosis

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