Brucella spp. lumazine synthase: a novel antigen delivery system

Sciutto, Edda; Toledo, Andrea; Cruz, C; Rosas, Gabriela; Meneses, Gabriela; Laplagne, Diego Andrés; Ainciart, Natalia; Cervantes, Jacquelynne; Fragoso, Gladis; Goldbaum, Fernando A.

doi:10.1016/j.vaccine.2004.11.043

Cited by 20 publications

(16 citation statements)

References 32 publications

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“…There is also evidence of orally induced effective protection against experimental murine cysticercosis by S3Pvac recombinantly bound to the polymeric Lumazine synthase protein from Brucella spp. [74,75] and by S3Pvac transgenic papaya clones [73]. Some efforts have been also done in experimental models as well against pig cysticercosis, albeit under experimental conditions using DNA vaccination, with successfully results [42-46, 61, 76-78].…”

Section: Alternatives For the Production Of A Vaccine For Massive Appmentioning

confidence: 99%

Vaccines Against Cysticercosis

Sciutto

Fragoso

Aluja³

et al. 2008

CTMC

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Taenia solium cysticercosis is a major parasitic disease that seriously and frequently affects human health and economy in undeveloped countries. Since pigs are an indispensable intermediate host, it is conceivable to curb transmission by reducing pig cysticercosis through their effective vaccination. This article reviews current knowledge on the development vaccines against porcine cysticercosis. It highlights the development of several versions of S3Pvac aimed to increase effectiveness, reduce costs and increase feasibility by novel delivery systems and alternative routes of administration.

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Section: Alternatives For the Production Of A Vaccine For Massive Appmentioning

confidence: 99%

Vaccines Against Cysticercosis

Sciutto

Fragoso

Aluja³

et al. 2008

CTMC

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“…It tolerates the insertion of a 12 aa KETc1, one of the peptides of the vaccine against Taenia solium cysticercosis, increasing the length of the inserted epitope and expressing it in multicopies. In a previous study, the immunogenic properties of BLS-KETc1 were successfully tested in subcutaneous immunization: KETc1 became antigenic, preserved its immunogenicity and its protective capacity, which overrode the use of any adjuvant [18,21]. In addition, the chimera exhibited remarkable thermodynamic stability including low and high extreme pH conditions.…”

Section: Introductionmentioning

confidence: 99%

Brucella spp. lumazine synthase: a novel adjuvant and antigen delivery system to effectively induce oral immunity

Rosas

Fragoso

Ainciart

et al. 2006

Microbes and Infection

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“…Bellido et al, 2012 was able to use BLS as an immuno modulator to enhance the antibody response in hens in order to increase egg yolk antibodies. BLS has been reported as a carrier for antigen delivery (Sciutto et al, 2005), based on its physicochemical and immunogenic properties (Zylberman et al, 2004). Rosas et al, (2006) showed that BLS can be used as both an antigen-carrier and as an adjuvant in the design of new oral subunit vaccines.…”

Section: Resultsmentioning

confidence: 99%