Brucella infection following total joint arthroplasty: A systematic review of the literature

Kim, Seung-Ju; Park, Hyunsoo; Lee, Dong Hoon

doi:10.1016/j.aott.2017.11.003

Cited by 6 publications

(7 citation statements)

References 22 publications

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“…There is no standardized antibiotic course for PJI caused by Brucella , with the shortest reported antibiotic regimen of 6 weeks and the longest of 26 months. 3 The current patient was cured by a combination of antibiotics given for 3 months after each step of the revision surgery. Diligent research is warranted to determine the optimal course of anti- Brucella drug treatment.…”

Section: Discussionmentioning

confidence: 99%

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Periprosthetic hip infections caused by Brucella: a rare case report and literature review

Feng,

Hao,

et al. 2024

J Int Med Res

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Periprosthetic hip infection caused by Brucella abortus is rare and only a few cases have been reported. This current case report presents a case of a man in his early 50s who developed periprosthetic hip infection 2 years after right hip arthroplasty. There was no fever or pain, the usual cardinal signs of infection, except for a sinus tract at the previous surgical incision. Laboratory and arthrocentesis culture examinations (done twice) confirmed infection with B. abortus. Accordingly, a two-stage revision surgery was performed accompanied by antibiotic treatment with doxycycline and rifampicin after each stage. There was no recurrence at the 2-year follow-up, with good functional recovery of the hip joint. Clinically, this case serves to highlight the fact that periprosthetic hip infections caused by B. abortus might not present with the typical symptoms such as fever or hip pain. Furthermore, this current case involved a chronic sinus tract, so the diagnostic and therapeutic course of this case offers useful insights for managing similar cases in the future. In addition, a review of the literature on the diagnosis and treatment of Brucella-caused periprosthetic hip infection is presented.

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Section: Discussionmentioning

confidence: 99%

“…2 Brucella -associated PJI is extremely rare, with only a few cases of Brucella periprosthetic hip infections reported in the literature. 3 This current report describes a rare case of Brucella infection of the hip PJI with sinus tract that was treated with two-stage revision surgery and a combination of antibiotics.…”

Section: Introductionmentioning

confidence: 95%

Periprosthetic hip infections caused by Brucella: a rare case report and literature review

Feng,

Hao,

et al. 2024

J Int Med Res

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“…Antibiotic therapy for at least 12 wk is recommended in osteoarticular brucellosis[ 7 , 12 ]. Antimicrobial therapy without surgical intervention may be feasible in cases of periprosthetic infection and the absence of radiological loosening[ 6 , 13 , 14 ]. Thus, successful outcomes have been reported in eight out of nine joints with periprosthetic infections due to Brucella and with well-fixed implants when treated solely with antibiotics over six to 52 wk[ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Periprosthetic knee joint infection caused by Brucella melitensis which was first -osteoarticular brucellosis or osteoarthrosis: A case report

Stumpner¹,

R²,

Hochreiter³

et al. 2023

World J Clin Cases

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BACKGROUND Brucellosis is the most common zoonosis worldwide and is endemic in the Middle East, Africa, Asia, and Latin America. However, it is uncommon in Central Europe, and periprosthetic infections caused by Brucella are therefore rare. Due to the low prevalence and nonspecific clinical presentation of the disease, accurate diagnosis can be challenging; no gold standard currently exists for treating brucellosis. CASE SUMMARY Here, we present a 68-year-old Afghan woman living in Austria with a periprosthetic knee infection caused by Brucella melitensis. The interval from total knee arthroplasty to septic loosening was five years. A profound medical history and examinations suggested that the patient had been suffering from unrecognized chronic osteoarticular brucellosis prior to total knee arthroplasty. She was successfully treated by two-stage revision surgery and combined antibiotic therapy over three months. CONCLUSION Clinicians should consider brucellosis as a possible cause of chronic arthralgia and periprosthetic infection in patients originating from countries with a high brucellosis burden.

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“…Spondylitis, sacroiliitis, osteomyelitis, and peripheral arthritis are the most frequently reported forms of osteoarticular involvement (8). Total knee arthroplasty, a common orthopedic procedure, may be followed by infection with gram-positive pathogens such as staphylococci and streptococci (9). Prosthetic joint infection is a serious complication of total joint arthroplasty, rarely caused by Brucella spp (10).…”

Section: Introductionmentioning

confidence: 99%

Bilateral Prosthetic Knee Joint Infection Caused by Brucella melitensis: A Rare Case Report from Iran

Shokouhi

Tehrani

Saleh

et al. 2022

Jundishapur J Microbiol

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Introduction: Brucella prosthetic joint infection is a rare condition. We report a case of bilateral prosthetic knee joint infection caused by Brucella melitensis, which was cured by prolonged antibiotic therapy without implant removal. Case Presentation: A 62-year-old woman was admitted to the Labbafinejad Hospital (Tehran, Iran), complaining of pain and swelling in her knee joints from two months ago. She was also suffering from intermittent fever and night sweats. She underwent bilateral total knee arthroplasty five years ago because of a severe degenerative joint disease. Agglutination tests (wright and 2-mercaptoethanol (2-ME)) were positive. Her knee joint fluid and blood cultures yielded B. melitensis. The polymerase chain reaction result from her knee joint fluid was positive for Brucella spp. The patient was cured after taking a combination of therapies with doxycycline, rifampin, and gentamicin. The prosthesis was retained due to the lack of loosening in radiography. Ten months after the treatment, the patient had no symptoms and could walk with no pain. Conclusions: Clinicians should consider brucellosis in the differential diagnosis of prosthetic joint infection in the endemic regions. They should also be aware that if patients have no sign of implant loosening, they can achieve favorable outcomes only by using antibiotics and with no need for implant removal.

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Brucella infection following total joint arthroplasty: A systematic review of the literature

Cited by 6 publications

References 22 publications

Periprosthetic hip infections caused by Brucella: a rare case report and literature review

Periprosthetic hip infections caused by Brucella: a rare case report and literature review

Periprosthetic knee joint infection caused by Brucella melitensis which was first -osteoarticular brucellosis or osteoarthrosis: A case report

Bilateral Prosthetic Knee Joint Infection Caused by Brucella melitensis: A Rare Case Report from Iran

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