Bruceine D restrains colorectal cancer tumorigenesis and autophagy by downregulating circ_0068464
Yong Yang,
Peng Li,
Xiaojia Li
et al.
Abstract:Bruceine D (BD) from Brucea javanica (L) exerts an antitumor effect in several human cancers. At present, it has not been reported whether BD inhibits the malignancy of colorectal cancer (CRC) cells. Therefore, investigating the role and regulatory mechanisms of BD in CRC is the main thrust of this study. Effect of BD on CRC cell viability, proliferation, apoptosis, invasion, and autophagy was determined by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide, 5‐ethynyl‐2′‐deoxyuridine, flow cytome… Show more
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