BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice

Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways

“…Bombesin-like receptor 3 (BRS3, BB3, bombesin receptor subtype-3) is an orphan G protein-coupled receptor that regulates energy metabolism and the cardiovascular system (Ohki-Hamazaki et al, 1997). BRS3 is expressed in some peripheral sites (Jensen et al, 2008), but its effects on food intake, metabolic rate, Tb, HR, and blood pressure are due to action in the brain (Guan et al, 2010;Xiao and Reitman, 2016 restricted brain distribution (Maruyama et al, 2018;Piñ ol et al, 2018;Zhang et al, 2013), with its metabolic effects attributed to glutamatergic neurons and in part to those expressing MC4R and SIM1 (Xiao et al, 2017(Xiao et al, , 2020. Activation of BRS3 neurons in the DMH (DMH BRS3 ) increased energy expenditure, Tb, HR, and blood pressure, while activation of paraventricular nucleus of the hypothalamus (PVH) BRS3 neurons reduced food intake (Piñ ol et al, 2018).…”

Effect of Sleeve Gastrectomy on Glycometabolism via Forkhead Box O1 (FoxO1)/Lipocalin-2 (LCN2) Pathway

“…The interaction of arcuate proopiomelanocortin and neurons expressed with locus-related peptides can coordinate long-term energy homeostasis [ 46 ]. The loss of MC4R function can lead to development of obesity, insulin resistance, and diabetes [ 47 ]. MC4Rs are widely expressed in the central nervous system and are involved in energy balance regulation and sympathetic nerve outflow [ 48 , 49 ].…”

Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways

“…BRS3 is expressed in some peripheral sites (Jensen et al, 2008), but its effects on food intake, metabolic rate, Tb, HR, and blood pressure are due to action in the brain (Guan et al, 2010; Xiao and Reitman, 2016). BRS3 has a restricted brain distribution (Maruyama et al, 2018; Pinol et al, 2018; Zhang et al, 2013), with its metabolic effects attributed to glutamatergic neurons and in part to those expressing MC4R and SIM1 (Xiao et al, 2020; Xiao et al, 2017). Activation of BRS3 neurons in the DMH (DMH BRS3 ) increased energy expenditure, Tb, HR, and blood pressure, while activation of paraventricular nucleus of the hypothalamus (PVH) BRS3 neurons reduced food intake (Pinol et al, 2018).…”