Browplasminin, a condensed tannin with anti-plasmin activity isolated from an aqueous extract of Brownea grandiceps Jacq. flowers

Pereira, Betzabeth; Brazón, Josmary; Rincón, Mónica; Vonasek, Eva

doi:10.1016/j.jep.2017.01.012

Cited by 13 publications

(16 citation statements)

References 40 publications

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“…These results are in accordance with studies that investigated the therapeutic properties of the J. mollissima latex and found phenolic compounds, 11,13,27,33 saponins, 13,27,33 tannins, flavonoids, 11,13,27,33 coumarins, alkaloids, and steroids. 11 The tannins, expressively found in the latex, have shown important antimicrobial, anti-inflammatory, and healing powers, being capable of controlling bleeding through their astringent effect over the contraction of damaged vessels and tissues, precipitating the proteins of blood and favoring hemostasis.…”

Section: Discussionsupporting

confidence: 92%

In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

et al. 2021

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Objective The objective of this study was to evaluate the hemostatic activity of the sap from Jatropha mollissima (Pohl) Baill. in rats. Materials and Methods Twenty-four Wistar rats were randomized into four groups (n = 6): the JM25 and JM40 groups were treated with ethanolic extract from the sap of J. mollissima, in a concentration of 25 and 40 mg·mL1, respectively; the MO group was treated with Monsel’s solution and the control group SC with a 0.9% sodium chloride solution. Statistical Analysis Data were submitted to the Kurskal–Wallis’ test, followed by Dunn’s post hoc (p < 0.05). Results There was a significant reduction in the bleeding time of the group from the JM25 extract (p = 0.001) when compared with MO and SC. There were no statistically significant differences between groups JM25 and JM40 (p > 0.05). The JM25 group did not present rebleeding, a result significantly different from the MO group (p = 0.001). Monsel’s solution showed significant bleeding, six times greater than the control group SC. Conclusion The J. mollissima extract, in the concentration of 25 mg·mL1, showed the highest hemostatic efficiency and was found to be a promising biomaterial for the elaboration of a hemostatic product.

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Section: Discussionsupporting

confidence: 92%

In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

et al. 2021

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“…Browplasminin is a condensed tannin with 47.80 μg/mL IC50 for plasmin. Although, this compound shows an inhibitory effect on the activity of plasmin, it has exhibited no decreasing effect on the activity of other serine-proteases such as trypsin, tPA or uPA (urokinase-type plasminogen activator) (29).…”

Section: Brownea Grandiceps Jacq (Fabaceae)mentioning

confidence: 90%

“…Despite the pro-coagulant effect of low BGE concentrations, 15000-25000 mg/mL concentrations exhibited anticoagulant activities by increasing PT, activated partial thromboplastin time (aPTT) and thrombin time (TT) (14). The inhibitory effect of Browplasminin on FXa is also observed by high concentrations (29). Overall, the low concentrations of BGE as tea infusion is recommended for the procoagulant and ant-fibrinolytic effect, resembling the infusion made in folk medicine for menorrhagia control.…”

Section: Brownea Grandiceps Jacq (Fabaceae)mentioning

confidence: 99%

Medicinal Plants as Potential Hemostatic Agents

et al. 2020

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Purpose: Medicinal plants with a variety of phytochemical ingredients remain a potential source for new drug discovery. The use of medicinal herbs in a wide range of diseases and symptoms, such as bleeding, is prevalent in traditional and ethno medicine worldwide. Thus, this work provides a comprehensive review of medicinal plants or their isolated compounds, with respect to their ethno-medicinal use, which have demonstrated the stimulating effect on the hemostasis process. Methods: The relevant studies were withdrawn from electronic databases including Pubmed, EMBASE and Web of Science with a structured search methodology. Results: The total of 17 medicinal plants with hemostatic activity were extracted. The most frequently studied plant families were Compositae, Lamiaceae, Fabaceae, and Asteraceae. Bioactive compounds exerting hemostatic activity included tannins, iridoid glycosides, glycoconjugate, lignan, saponins and phenolic compounds. The most attributed mechanisms include coagulation stimulation via increasing the factor XII activity and plasma fibrinogen levels, the fibrinolysis inhibition, vascular or smooth muscle constriction and platelet aggregation. The most important adverse effects of high dose extract or isolated compounds administration were hepatotoxicity and nephrotoxicity. Conclusion: This review provides a list of medicinal plants with hemostatic activity that could be used as valuable sources of new plant-based hemostatic agents. Furthermore, this could be practical in detecting possible interactions of plants with anticoagulant, antiplatelet, fibrinolytic and antifibrinolytic medications. __________________________________________________________________________________________

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“…Using a chromogenic substrate, it has been shown that the procyanidin fraction of an aqueous extract of Brownea grandiceps Jacq. (Fabaceae) flowers attenuated the activity of factor Xa (IC 50 237.08 μg/ml) ( Pereira et al, 2017 ). Procyanidin B2 was also found to act as an inhibitor of factor Xa.…”

Section: Tannins and Coagulation Systemmentioning

confidence: 99%

Tannins as Hemostasis Modulators

Marcińczyk

Gromotowicz-Popławska

Chabielska

2022

Front. Pharmacol.

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The hemostasis system is often affected by complications associated with cardiovascular diseases, which results in thromboembolic events. Compounds of plant origin and plant extracts are considered as a promising source of substances that could modulate the functioning of the hemostasis system and thus reduce the risk of thromboembolism. Among them, tannins, which are plant-origin compounds with potential effects in hemostasis, deserve a special mention. This paper describes the hemostasis-modifying ability of three groups of tannins, namely ellagitannins, gallotannins, and procyanidins. The review highlights the desirable as well as undesirable influence of tannins on specific components of hemostasis, namely platelets, coagulation system, fibrinolysis system, and endothelium, and the multidirectional effect of these compounds on the thrombotic process. Studies performed under normal and pathological conditions such as diabetes or hypercoagulation are described, and the pathophysiology-dependent action of tannins is also highlighted. Most of the studies presented in the paper were performed in vitro, and due to the low bioavailability of tannins more studies should be conducted in the future to understand their actual activity in vivo.

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Browplasminin, a condensed tannin with anti-plasmin activity isolated from an aqueous extract of Brownea grandiceps Jacq. flowers

Cited by 13 publications

References 40 publications

In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

Medicinal Plants as Potential Hemostatic Agents

Tannins as Hemostasis Modulators

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