Brown tumour presenting as a soft-tissue mass

Ergen, Fatma Bilge; Ayvaz, Muhammed Ali; Yıldız, Atilla; Aydıngöz, Üstün; Gedikoğlu, Gökhan

doi:10.1016/j.crad.2011.09.005

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…Brown tumors result from heightened osteoclast activity triggered by excessive levels of parathyroid hormone. They are closely related to primary hyperparathyroidism, and approximately 3% of patients with primary hyperparathyroidism develop brown tumors [22]. It can usually affect any part of the skeletal system, including the skull (usually the jawbone), cranial bones, clavicles, ribs, pelvic bones, femur, and spine.…”

Section: Discussionmentioning

confidence: 99%

A Case Report and Literature Review of a Giant Parathyroid Adenoma with Digestive System Symptoms and Brown Tumor

Pan,

Zhao,

Wang

et al. 2024

Preprint

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Background: A parathyroid adenoma stands as the primary cause of primary hyperparathyroidism, and clinically it often presents with symptoms such as elevated blood calcium levels and recurrent kidney stones. Parathyroid adenoma discovered due to symptoms such as nausea and vomiting is relatively rare. Case presentation: A 59-year-old woman was hospitalized due to symptoms of nausea and vomiting. Imaging studies unveiled a solid mass located on the posterior aspect of the left thyroid lobe, potentially of parathyroid origin, along with multiple bone destruction throughout the body. Laboratory tests showed elevated serum total calcium, low potassium, and increased parathyroid hormone levels. The final diagnosis was primary hyperparathyroidism complicated by the brown tumor. Symptomatic treatment, including calcium reduction, fluid replacement, and electrolyte supplementation, was initiated. Subsequently, parathyroid adenoma resection was performed. Postoperatively, the patient developed hungry bone syndrome, which was treated with calcium supplementation, and follow-up showed normalization of blood calcium levels. Conclusions: Unexplained nausea accompanied by electrolyte disturbances should raise suspicion of rare causes such as primary hyperparathyroidism. When there are multiple systemic osteolytic changes, brown tumor should be considered, along with assessment of serum calcium and parathyroid hormone levels for diagnosis.

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Section: Discussionmentioning

confidence: 99%

A Case Report and Literature Review of a Giant Parathyroid Adenoma with Digestive System Symptoms and Brown Tumor

Pan,

Zhao,

Wang

et al. 2024

Preprint

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“…The incidence of brown tumor has been reported to be 3 % in patients with primary hyperparathyroidism, in contrast to 1.5–1.7 % in secondary hyperparathyroidism [ 6 ]. Lesions can affect any skeletal structure and can be solitary or multiple, but they are more commonly localized along long bones, the pelvis, ribs, and clavicles [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Usually with bone expansion and can demonstrate bony destruction and be associated with pathological fractures [ 1 , 7 ]. Sometimes soft-tissue extension from the affected bone lesion is observed on CT scann [ 6 ]. Radiographically, multiple bone lesions of brown tumor may be misdiagnosed as multiple myeloma, metastatic carcinoma, lymphangiomatosis, leukaemia, Langerhans' cell histiocytosis, multiple bone cysts, or multiple non-ossifying fibromas [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Brown tumor of the jaw as a rare manifestation of hyperparathyroidism: Two case reports and literature review

Hakkou,

Benjelloun,

Hallab

et al. 2023

International Journal of Surgery Case Reports

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“…It is associated more commonly with primary hyperparathyroidism [ 8 ]. Approximately 3% of patients with primary hyperparathyroidism develop brown tumors [ 9 ]. The solitary adenoma is the most common cause of primary hyperparathyroidism, resulting in excessive parathyroid hormone secretion (PTH) [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Multiple Brown Tumors in Primary Hyperparathyroidism Causing Pathological Fracture: A Case Report of a 21-Year-Old Adult Male

Aldosari¹,

Alghamdi²,

Alragea³

2023

Cureus

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Multiple brown tumors are more common in females and older age groups and an unlikely site is the long bones. We report a case of a 21-year-old male presenting with a pathological fracture at the left neck of the femur. Laboratory investigations showed elevated parathyroid hormone (PTH) and serum calcium levels (PTH-dependent hypercalcemia). A CT scan revealed multiple osteolytic lesions in the pelvis and femurs, and a Tc-99m sestamibi scan showed a solitary parathyroid adenoma. We demonstrate this rare case and illustrate the importance of the consideration of multiple brown tumors in young males presenting with multiple osteolytic lesions at the long bones in the differential diagnosis. Every physician needs to have a high clinical suspicion of primary hyperparathyroidism innovation, in those who present with osteolytic lesions, with respect to the patient’s age and gender.

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Brown tumour presenting as a soft-tissue mass

Cited by 8 publications

References 9 publications

A Case Report and Literature Review of a Giant Parathyroid Adenoma with Digestive System Symptoms and Brown Tumor

A Case Report and Literature Review of a Giant Parathyroid Adenoma with Digestive System Symptoms and Brown Tumor

Brown tumor of the jaw as a rare manifestation of hyperparathyroidism: Two case reports and literature review

Multiple Brown Tumors in Primary Hyperparathyroidism Causing Pathological Fracture: A Case Report of a 21-Year-Old Adult Male

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