Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature

Triantafillidou, Katherine; Zouloumis, Lambros; Karakinaris, G.; Kalimeras, Elettherios; Iordanidis, Fotis

doi:10.1016/j.amjoto.2005.11.004

Cited by 140 publications

(150 citation statements)

References 19 publications

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“…Bone involvement is the late manifestation [7]. In the past, bones lesions were recognized in 80% to 90% of patients with primary or secondary hyperparathyroidism [4]. This rate has decreased to less than 5% of cases because of early diagnosis by routine biochemical screening and successful treatment of the disease [4,8].…”

Section: Discussionmentioning

confidence: 99%

“…In the past, bones lesions were recognized in 80% to 90% of patients with primary or secondary hyperparathyroidism [4]. This rate has decreased to less than 5% of cases because of early diagnosis by routine biochemical screening and successful treatment of the disease [4,8]. Classic skeletal lesions are bone resorption, bone cysts, brown tumors and generalized osteopenia [6].…”

Section: Discussionmentioning

confidence: 99%

“…Most cases of primary hyperparathyroidism are identified by hypercalcemia and hypophosphatemia on routine serum testing [3,4]. Cases recognized by the presence of brown tumors are uncommon [4]. In this paper we report a case, of a large swelling in the palate corresponding to a maxillary brown tumor related to primary hyperparathyroidism, whitch is an unusual first manifestation of the disease.…”

mentioning

confidence: 94%

“…It is caused by parathyroid adenoma (81%), hyperplasia (15%) or carcinoma (0.5-4%) [3]. Most cases of primary hyperparathyroidism are identified by hypercalcemia and hypophosphatemia on routine serum testing [3,4]. Cases recognized by the presence of brown tumors are uncommon [4].…”

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confidence: 99%

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Brown tumor of the palate as first manifestation of primary hyperparathyroidism: a case report

Chami¹,

Benrachadi

Omri

et al. 2011

Med Buccale Chir Buccale

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-Brown tumor is one of the lesions that develop in patients with hyperparathyroidism. Skeletal bones including maxillo-facial ones can be the site of this lesion. Owing to the improve methods of blood analysis most of cases of primary hyperparathyroidism are diagnosed early and asymptomatically making advanced disease with bone lesions extremely rare. This article contains a case of a 43-year-old female patient who presented with palatal swelling as the first sign of primary hyperparathyroidism. The diagnosis was suggested by the histological findings and confirmed by the endocrinologic status.Résumé -Tumeur brune du palais comme première manifestation d'un hyperparathyroïdisme primaire. Présentation d'un cas. La tumeur brune représente une des lésions que l'on peut observer dans l'hyperparathyroïdisme. Elle touche les os, y compris ceux de la région maxillo-faciale. Le bilan biologique permet de diagnostiquer la plupart des cas d'hyperparathyroïdisme primaire à un stade précoce ; les formes évoluées asymptomatiques sont extrémement rares. Cet article présente un cas d'hyperparathyroïdisme primaire, chez une femme de 43 ans, où la première manifestation était constituée par une tuméfaction palatine. Le diagnostic a été évoqué à l'examen histologique et confirmé par le bilan endocrinien.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 94%

mentioning

confidence: 99%

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Brown tumor of the palate as first manifestation of primary hyperparathyroidism: a case report

Chami¹,

Benrachadi

Omri

et al. 2011

Med Buccale Chir Buccale

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“…However, foremost risk factors which escalates the risk of parathyroid disease are tumor of jaw, chronic renal failure, interaction of multiple environment, genetic and exposure to radiation especially during childhood (Triantafillidou et al, 2006 (Cole, 2012). The hyperglycosylated HCG is formed by cytotrophoblast cells and elevated in most advanced malignancies (Cole et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Significance of HCG to Distinguish Parathyroid Carcinoma from Benign Disease and in Adding Prognostic Information: A Hospital Based Study from Nepal

Gupta

Mittal²,

Sathian³

2013

Asian Pacific Journal of Cancer Prevention

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Objective: To differentiate between benign and malignant hyperparathyroidism on the basis of excretion of HCG and its malignant isoforms in urine. Materials and Methods: This hospital based study was carried out using data retrieved from the register maintained in Manipal Teaching Hospital from 1 st January, 2008 and 31 st August, 2012. The variables collected were urinary HCG and HCG malignant isoform, calcium and parathyroid hormone. Preceding the study, approval was obtained from the institutional research ethical committee. Analysis was by descriptive statistics and testing of hypothesis. A p-value of <0.05 (two-tailed) was used to establish statistical significance. Results: Out of the 20 cases, 10 were primary hyperparathyroidism and the remainder were parathyroid carcinomas. The urinary HCG 6.1±0.6 fmol/mgCr was with in normal range in benign hyperthyroidism but was markedly elevated in three cases of malignant hyperparathyroidism (maximum value of excretion in urine for HCG was 2323 fmol/mgCr). The excretion of malignant isoform of HCG in urine was 0 in benign hyperparathyroidsm and in four cases of malignant hyperparathyroidism which fell into the category of persistantly low HCG. The maximum excretion of the malignant isoform of HCG in urine was 1.8, in the category of very high HCG. Calcium and parathyroid hormone were mildly raised in benign parathyroidism, while parathyroid hormone was markedly elevated in cases of malignant hyperparathyroidism falling into the category of very high HCG. Conclusions: The excretion of urinary HCG in urine has the ability to distinguish between parathyroid adenomas and carcinomas and thus has potential to become a marker of disease progression in malignant parathyroid disease.

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Tumor of Maxilla in a Patient With Hypercalcemia

Rafizadeh

Duarte

Lai

et al. 2013

JAMA Otolaryngol Head Neck Surg

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Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature

Cited by 140 publications

References 19 publications

Brown tumor of the palate as first manifestation of primary hyperparathyroidism: a case report

Brown tumor of the palate as first manifestation of primary hyperparathyroidism: a case report

Significance of HCG to Distinguish Parathyroid Carcinoma from Benign Disease and in Adding Prognostic Information: A Hospital Based Study from Nepal

Tumor of Maxilla in a Patient With Hypercalcemia

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