Brown Tumors: A Case Report and Review of the Literature

Can, Özgür; Boynueğri, Başak; Gökçe, Ali Murat; Özdemir, Ebru; Ferhatoğlu, Ferhat; Canbakan, Mustafa; Şahin, Gülizar Manga; Titiz, M.I.; Apaydın, Süheyla

doi:10.1159/000444703

Cited by 36 publications

(38 citation statements)

References 13 publications

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“…Brown tumors [ 8 9 10 ] are nonneoplastic osteolytic lesions in the bones due to excessive osteoclastic activity as a part of the metabolic abnormality in HPT. Any bone may be involved, though common locations are mandible, maxilla, palate, nasal cavity, paranasal sinuses, orbit, and temporal bones.…”

Section: Discussionmentioning

confidence: 99%

Unusually Large Brown tumor of Mandible in a Case of Secondary Hyperparathyroidism Mimicking Cherubism

et al. 2018

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We report here a case of unusually large brown tumor of mandible mimicking cherubism in a patient with secondary hyperparathyroidism (HPT). The patient is a young male with a large head and a protruding jaw with an open mouth appearance. Initial clinical appearance looked like cherubism. However further clinical, biochemical, and radiological evaluation revealed a large brown tumor in a case of prolonged secondary HPT, which was confirmed on histopathology. All of the typical advanced radiological features of HPT were noted, highlighting the severity of progression of the disease. This case emphasizes the need for surveillance of serum calcium levels on routine biochemical investigations as to enable an early diagnosis of HPT. With timely proper management, such cases should be on the decline in the future.

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Section: Discussionmentioning

confidence: 99%

Unusually Large Brown tumor of Mandible in a Case of Secondary Hyperparathyroidism Mimicking Cherubism

et al. 2018

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“…It is also common in the long bones, ribs, and the pelvis. The lesion could be located in any part of the bones [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Brown tumor presents as a fixated growing mass with bony consistency. The tumor itself is usually asymptomatic but causes disability in chewing, talking, and breathing if it occurs in the craniofacial region [ 8 ]. It may also cause secondary back pain or acute spinal compression if it occurs in the spinal cord [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital

Kartini

Siswiandari

Wibisana

et al. 2018

Case Reports in Oncological Medicine

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Brown tumor is a bone lesion that arises in the setting of excess osteoclast activity in hyperparathyroidism. It consists of fibrous tissue, woven bone, and supporting vasculature, while contains no matrix. The characteristic of brown-colored lesion is a result of hemosiderin deposition into the osteolytic cysts. Two cases of young women aged 26 and 29 years old, respectively, are known with a history of end-stage renal disease (ESRD). Dialysis is performed two times/week over the last 7 years. Our patients presented with an intraoral mass of the hard palate since 12 months ago and decreased body height of 10 cm. The lesion causes difficulties in swallowing and talking. Laboratory workup showed elevated parathormone or PTH (3.391 pg/mL and >5.000 pg/mL). Neck ultrasound showed enlargement of the parathyroid glands. Supporting examination to diagnose brown tumor are neck ultrasound, CT of the neck, and parathyroid sestamibi scan. We performed parathyroidectomy. Pathology revealed hyperplasia of the parathyroid. The tumor regressed significantly within 2 weeks following the surgery, and we still observe tumor regression as well as reduction in PTH level. As clinicians, we should be alert to other possible causes of bony lesions. Clinical examination, laboratory finding, and imaging present important information to diagnose brown tumor.

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“…However, clinically significant lesion in craniofacial bone is not common. 3 The name of this metabolic bone lesion is derived from its characteristic dark brown color. Brown color is caused by abundant haemorrhage and deposition of haemosiderin pigments within the lesion.…”

Section: Introductionmentioning

confidence: 99%

Brown Tumour of Jaw Bone: A Diagnostic Attribute of Hyperparathyroidism

Baral

Ojha

Bajracharya

et al. 2017

J Nepal Soc Perio Oral Implantology

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Brown tumour is an uncommon focal giant cell lesion that arises as a result of direct effect of parathyroid hormone on bone tissue in patients with hyperparathyroidism. The lesion is characterized by extensive bone resorption which is replaced by fibrovascular tissue and giant cell with abundant deposit of haemosiderin. A rare case of Brown tumour in maxilla and mandible in 57-year-old female patient is reported. This case report highlights the importance of detailed systemic investigation for all the maxillofacial lesions since it could be the diagnostic attribute of the systemic diseases.

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Brown Tumors: A Case Report and Review of the Literature

Cited by 36 publications

References 13 publications

Unusually Large Brown tumor of Mandible in a Case of Secondary Hyperparathyroidism Mimicking Cherubism

Unusually Large Brown tumor of Mandible in a Case of Secondary Hyperparathyroidism Mimicking Cherubism

Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital

Brown Tumour of Jaw Bone: A Diagnostic Attribute of Hyperparathyroidism

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