Brown spiders and loxoscelism

Silva, Paulo Henrique da; Silveira, Rafael Bertoni da; Appel, Márcia Helena; Mangili, Oldemir C.; Gremski, Waldemiro; Veiga, Sílvio Sanches

doi:10.1016/j.toxicon.2004.07.012

Cited by 213 publications

(205 citation statements)

References 101 publications

Supporting

Mentioning

193

Contrasting

Unclassified

Order By: Relevance

“…The adaptive ability of these spiders to adverse conditions may explain why they are capable of surviving in such different parts of the world (7). Loxosceles spiders may resist temperatures varying from 8 to 43ºC and can survive for several months without food or water (8,9).…”

Section: Introductionmentioning

confidence: 99%

“…Brown spider venom presents a complex composition and contains different proteolytic and hemolytic toxins (8,10,12). The bite may be unnoticed or there may be pain similar to mild burn (8).…”

Section: Introductionmentioning

confidence: 99%

“…The bite may be unnoticed or there may be pain similar to mild burn (8). Few hours after the bite, an edematous plaque with vesicles and ecchymosis appear where venom was inoculated (8).…”

Section: Introductionmentioning

confidence: 99%

“…The bite may be unnoticed or there may be pain similar to mild burn (8). Few hours after the bite, an edematous plaque with vesicles and ecchymosis appear where venom was inoculated (8). This lesion is called marmoreal plaque because of its blue (cyanosis), white (ischemia) and red (erythema) colors and it may evolve to necrosis and long lasting ulcers (12,13).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Necrotic skin lesion in a dog attributed to Loxosceles (brown spider) bite: a case report

Machado¹,

Antunes²,

Mazini³

et al. 2009

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

ABSTRACT:Envenomations caused by Loxosceles (brown spider) have been reported throughout the world. Clinical signs associated to bites of these spiders involve dermonecrotic lesions and intense local inflammatory response, besides systemic manifestations such as intravascular hemolysis, thrombocytopenia, disseminated intravascular coagulation and acute renal failure. The present study aimed to report and to describe dermonecrotic lesions probably caused by a Loxosceles envenomation in a four year-old poodle female dog, treated at the Dermatology Service of the Veterinary Hospital of the Veterinary Medicine and Animal Husbandry School, São Paulo State University, Botucatu, Brazil. Initially, the animal presented two skin lesions with blackish aspect that evolved into ulcerative crusts. The owner reported the presence of a brown spider near the place where the animal spent most of the time. Histological examination of lesions revealed necrosis of the epidermis extending to adnexa and panniculi, which is compatible with Loxosceles bite reaction. The animal was treated with systemic antibiotic and local curatives. Lesions healed by second intention in two months.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The bite may be unnoticed or there may be pain similar to mild burn (8). Few hours after the bite, an edematous plaque with vesicles and ecchymosis appear where venom was inoculated (8).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Necrotic skin lesion in a dog attributed to Loxosceles (brown spider) bite: a case report

Machado¹,

Antunes²,

Mazini³

et al. 2009

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

show abstract

“…First, Mebs acknowledged that the venom was a gift (i.e., he did not collect it). Second, though there appear to be exceptions (Young and Pincus 2001;da Silva et al 2004), very little peptidase activity has been observed in spider venoms that have been collected so as to avoid contamination by regurgitated digestive fluid (see Perret 1977, Geren and Odell 1984, and Kuhn-Nentwig et al 1994 for reviews of this problem). And third, as indicated above, the digestive fluid peptidases share several characteristics with the peptidases Mebs described.…”

Section: Introductionmentioning

confidence: 99%

Astacin family metallopeptidases and serine peptidase inhibitors in spider digestive fluid

Foradori

Tillinghast

Smith

et al. 2006

Comparative Biochemistry and Physiology Part B: Biochemistry an

View full text Add to dashboard Cite

Digestive fluid of the araneid spider Argiope aurantia is known to contain zinc metallopeptidases. Using anion-exchange chromatography, size-exclusion chromatography, sucrose density gradient centrifugation, and gel electrophoresis, we isolated two lower-molecular-mass peptidases, designated p16 and p18. The N-terminal amino acid sequences of p16 (37 residues) and p18 (20 residues) are 85% identical over the first 20 residues and are most similar to the N-terminal sequences of the fully active form of meprin (β subunits) from several vertebrates (47-52% and 50-60% identical, respectively). Meprin is a peptidase in the astacin (M12A) subfamily of the astacin (M12) family. Additionally, a 66-residue internal sequence obtained from p16 aligns with the conserved astacin subfamily domain. Thus, at least some spider digestive peptidases appear related to astacin of decapod crustaceans. However, important differences between spider and crustacean metallopeptidases with regard to isoelectric point and their susceptibility to hemolymph-borne inhibitors are demonstrated. Anomalous behavior of the lower-molecular-mass Argiope peptidases during certain fractionation procedures indicates that these peptidases may take part in reversible associations with each other or with other proteins. A. aurantia digestive fluid also contains inhibitory activity effective against insect digestive peptidases. Here we present evidence for at least thirteen, heat-stable serine peptidase inhibitors ranging in molecular mass from about 15 to 32 kDa.

show abstract

Spiders (Order: Araneae)

Barceloux

2008

Medical Toxicology of Natural Substances

View full text Add to dashboard Cite

Brown spiders and loxoscelism

Cited by 213 publications

References 101 publications

Necrotic skin lesion in a dog attributed to Loxosceles (brown spider) bite: a case report

Necrotic skin lesion in a dog attributed to Loxosceles (brown spider) bite: a case report

Astacin family metallopeptidases and serine peptidase inhibitors in spider digestive fluid

Spiders (Order: Araneae)

Contact Info

Product

Resources

About