Brown and white fat during the life of the rabbit

Derry, D. M.; Morrow, Eric; Sadre, N L; Flattery, K. V.

doi:10.1016/0012-1606(72)90098-x

Cited by 17 publications

(10 citation statements)

References 48 publications

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“…Brown fat is converted to white fat in the interscapular region of the rabbit as it ages, which correlates with the disappearance of catecholamines from the sympathetic nerve fibers in arterial blood vessels in both brown and white fat 203 . The peritoneal mesothelium of the anterior abdominal wall of the rabbit is characterized by flattened mesothelial cells with tight junctions, desmosomes, cytoplasmic pinocytic vesicles and microvilli 204 .…”

Section: Section 15: Soft Tissue (Soft Tissue Mesothelium Adipose Skeletal and Smooth Muscle)mentioning

confidence: 93%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

et al. 2021

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand. asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the laboratory rabbit used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Section 15: Soft Tissue (Soft Tissue Mesothelium Adipose Skeletal and Smooth Muscle)mentioning

confidence: 93%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

et al. 2021

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“…In humans, BAT activity has beneficial metabolic effects on obesity, insulin resistance and atherosclerosis [5]. Although BAT can be found in most new-born animals, there is a difference in BAT development among different species [6][7][8]. The hibernating animal and some rodents persist in their BATs into adult life [9,10].…”

Section: Introductionmentioning

confidence: 99%

De Novo Reconstruction of Transcriptome Identified Long Non-Coding RNA Regulator of Aging-Related Brown Adipose Tissue Whitening in Rabbits

Xue

et al. 2021

Biology

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Brown adipose tissues (BATs) convert to a “white-like” phenotype with age, which is also known as “aging-related BAT whitening (ARBW)”. Emerging evidence suggested that long non-coding RNAs (lncRNAs) were widely involved in adipose biology. Rabbit is an ideal model for studying the dynamics of ARBW. In this study, we performed histological analysis and strand-specific RNA-sequencing (ssRNA-seq) of rabbit interscapular adipose tissues (iATs). Our data indicated that the rabbit iATs underwent the ARBW from 0 days to 2 years and a total of 2281 novel lncRNAs were identified in the iATs. The classical rabbit BATs showed low lncRNA transcriptional complexity compared to white adipose tissues (WATs). A total of 631 differentially expressed lncRNAs (DELs) were identified in four stages. The signal pathways of purine metabolism, Wnt signaling pathway, peroxisome proliferator-activated receptor (PPAR) signaling pathway, cyclic guanosine monophosphate (cGMP)/cGMP-dependent protein kinase (cGMP-PKG) signaling pathway and lipid and atherosclerosis were significantly enriched by the DELs with unique expression patterns. A novel lncRNA that was highly expressed in the iATs of aged rabbits was validated to impair brown adipocyte differentiation in vitro. Our study provided a comprehensive catalog of lncRNAs involved in ARBW in rabbits, which facilitates a better understanding of adipose biology.

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“…Instead, a fat pad with a phenotype similar to WAT emerges to take its place [ 20 ], suggesting that brown adipocytes within iBAT change into white adipocytes with age in humans. A similar whitening phenomenon occurs in rabbits where iBAT is developmentally reprogrammed to a ‘WAT-like’ phenotype after birth [ 12 , 21 ]. However, a detailed molecular description together with a non-invasive live imaging system to monitor the dynamic changes during the process of iBAT whitening is lacking.…”

Section: Introductionmentioning

confidence: 82%

“…This process occurs in non-shivering thermogenesis (NST) and is believed to be important for the maintenance of normal body temperature in mammals, such as rodents, hibernating animals and newborn infants [ 7 , 8 ]. Unlike rodents where BAT is present functionally throughout their lifespan, human beings and other animals such as ruminants and rabbits [ 9–11 ] are believed to possess functional BAT for only a short period of time after birth whereafter it is replaced by WAT [ 12 ]. Thus, historically it has been widely accepted that adults possess little or no metabolically active BAT.…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions

Wan

Long

et al. 2022

Adipocyte

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Interscapular brown adipose tissue (iBAT) of both rabbits and humans exhibits a similar whitening phenomenon under physiological conditions. However, a detailed characterization of iBAT whitening in them is still lacking. Here, we chose rabbits as a model to gain a better understanding of the molecular signature changes during the whitening process of iBAT by transcriptomic analysis of rabbit iBAT at day 1, day 14, 1 month and 4 months after birth. We applied non-invasive MRI imaging to monitor the whitening process and correlated these changes with analysis of morphological, histological and molecular features. Principal component analysis (PCA) of differentially expressed genes delineated three major phases for the whitening process as Brown, Transition and Whitened BAT phases. RNA-sequencing data revealed that whitening of iBAT was an orchestrated process where multiple types of cells and tissues participated in a variety of physiological processes including neovascularization, formation of new nervous networks and immune regulation. Several key metabolic and signalling pathways contributed to whitening of iBAT, and immune cells and immune regulation appeared to play an overarching role.

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Brown and white fat during the life of the rabbit

Cited by 17 publications

References 48 publications

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

De Novo Reconstruction of Transcriptome Identified Long Non-Coding RNA Regulator of Aging-Related Brown Adipose Tissue Whitening in Rabbits

Comparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions

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