Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism

Cerri, Gabriela Cavazza; Santos, Sérgio Henrique Sousa; Bäder, Michael; Santos, Robson Augusto Souza

doi:10.1016/j.jnutbio.2023.109268

Cited by 3 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…93 Important alterations in the expression of genes related to sugar and fat metabolism were also reported in MrgD-knockout mice. 94 It should be mentioned that further studies are necessary to reveal the aspartate-decarboxylating enzyme(s) involved in the formation of Ang A and alamandine in the body. In this respect, Jha et al 95 recently postulated a role of bacterial β-decarboxylases in the formation of alamandine in the gut, but these enzymes cannot explain the presence of the peptide in most other parts of the body.…”

Section: Alamandinementioning

confidence: 99%

Alternative Renin-Angiotensin System

Bader,

Steckelings,

Alenina

et al. 2024

Hypertension

Self Cite

View full text Add to dashboard Cite

The renin-angiotensin system is the most important peptide hormone system in the regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin, and angiotensin-converting enzyme, generating angiotensin II from angiotensinogen, which activates its AT 1 receptor, thereby increasing blood pressure, retaining salt and water, and inducing cardiovascular hypertrophy and fibrosis. However, angiotensin II can also activate a second receptor, the AT 2 receptor. Moreover, the removal of the C-terminal phenylalanine from angiotensin II by ACE2 (angiotensin-converting enzyme 2) yields angiotensin-(1-7), and this peptide interacts with its receptor Mas. When the aminoterminal Asp of angiotensin-(1-7) is decarboxylated, alamandine is generated, which activates the Mas-related G-protein-coupled receptor D, MrgD (Mas-related G-protein-coupled receptor type D). Since Mas, MrgD, and the AT 2 receptor have opposing effects to the classical AT 1 receptor, they and the enzymes and peptides activating them are called the alternative or protective arm of the renin-angiotensin system. This review will cover the historical aspects and the current standing of this recent addition to the biology of the renin-angiotensin system.

show abstract

Section: Alamandinementioning

confidence: 99%

Alternative Renin-Angiotensin System

Bader,

Steckelings,

Alenina

et al. 2024

Hypertension

Self Cite

View full text Add to dashboard Cite

show abstract

“…Little is known regarding the role of the alamandine/MrgD axis, but Cerri et al (2023) found that the deletion of the MrgD receptor caused significant alterations in the size, functionality, and gene expression of BAT, impairing its response to a caloric challenge. This suggests that MrgD plays a critical role in the metabolism, mediated by decreased AMPK signaling in BAT (Cerri et al, 2023).…”

Section: Role Of the Ras Counterregulatory Axismentioning

confidence: 99%

“…The effects of the MrgD activation and its impact on the browning and whitening of adipose tissue remain unknown. Recently, Cerri et al suggested that the Alamandine receptor may play a role in preventing BAT whitening, once MrgD‐knockout animals showed a decrease in BAT mass, impaired mitochondrial biogenesis, and reduced RNA levels of UCP1, PGC‐1α, and AMPK (Cerri et al, 2023). Another study proposed that Mas and MrgD receptors may elicit opposing actions in adipose tissue, though this was seen for leptin regulation and not browning or whitening markers (Uchiyama et al, 2017).…”

Section: Adipose Tissue Plasticitymentioning

confidence: 99%

Adipose tissue plasticity mediated by the counterregulatory axis of the renin‐angiotensin system: Role of Mas and MrgD receptors

Proença,

Medeiros,

Reis

et al. 2024

Journal Cellular Physiology

View full text Add to dashboard Cite

The renin‐angiotensin system (RAS) is an endocrine system composed of two main axes: the classical and the counterregulatory, very often displaying opposing effects. The classical axis, primarily mediated by angiotensin receptors type 1 (AT1R), is linked to obesity‐associated metabolic effects. On the other hand, the counterregulatory axis appears to exert antiobesity effects through the activation of two receptors, the G protein‐coupled receptor (MasR) and Mas‐related receptor type D (MrgD). The local RAS in adipose organ has prompted extensive research into white adipose tissue and brown adipose tissue (BAT), with a key role in regulating the cellular and metabolic plasticity of these tissues. The MasR activation favors the brown plasticity signature in the adipose organ by improve the thermogenesis, adipogenesis, and lipolysis, decrease the inflammatory state, and overall energy homeostasis. The MrgD metabolic effects are related to the maintenance of BAT functionality, but the signaling remains unexplored. This review provides a summary of RAS counterregulatory actions triggered by Mas and MrgD receptors on adipose tissue plasticity. Focus on the effects related to the morphology and function of adipose tissue, especially from animal studies, will be given targeting new avenues for treatment of obesity‐associated metabolic effects.

show abstract

“…The role of alamandine on adipose tissue remains to be elucidated. A recent study demonstrated increased white adipose tissue (WAT) and reduction in BAT in MrgD knockout mice [ 192 ]. Nitric oxide (NO) and 5’-AMP-activated protein kinase (AMPK) regulated glucose metabolism through increased expression and expression of GLUT4 in the skeletal muscles [ 193 ].…”

Section: Reviewmentioning

confidence: 99%

Renin-Angiotensin System: Updated Understanding and Role in Physiological and Pathophysiological States

Kanugula¹,

Kaur²,

Batra³

et al. 2023

Cureus

View full text Add to dashboard Cite

The classical view of the renin-angiotensin system (RAS) is that of the circulating hormone pathway involved in salt and water homeostasis and blood pressure regulation. It is also involved in the pathogenesis of cardiac and renal disorders. This led to the creation of drugs blocking the actions of this classical pathway, which improved cardiac and renal outcomes. Our understanding of the RAS has significantly expanded with the discovery of new peptides involved in this complex pathway. Over the last two decades, a counterregulatory or protective pathway has been discovered that opposes the effects of the classical pathway. Components of RAS are also implicated in the pathogenesis of obesity and its metabolic diseases. The continued discovery of newer molecules also provides novel therapeutic targets to improve disease outcomes. This article aims to provide an overview of an updated understanding of the RAS, its role in physiological and pathological processes, and potential novel therapeutic options from RAS for managing cardiorenal disorders, obesity, and related metabolic disorders.

show abstract

Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism

Cited by 3 publications

References 48 publications

Alternative Renin-Angiotensin System

Alternative Renin-Angiotensin System

Adipose tissue plasticity mediated by the counterregulatory axis of the renin‐angiotensin system: Role of Mas and MrgD receptors

Renin-Angiotensin System: Updated Understanding and Role in Physiological and Pathophysiological States

Contact Info

Product

Resources

About