Brown Adipose Tissue: Receptors and Recruitment

Nedergaard, Jan; Cannon, Barbara

doi:10.1007/978-3-0348-8491-4_55

Cited by 1 publication

(1 citation statement)

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“…Is heat production regulated? Although BAT's only known function is to produce heat, and although BAT normally reaches its peak development during the first week postpartum (Nedergaard, Connolly, & Cannon, 1986), it nonetheless does not produce enough heat to maintain a constant colonic temperature even during relatively mild cold exposure (Conklin & Heggeness, 1971). This failure has led investigators to conclude that rat pups are born without homeostatic control of body temperature, and that this control does not develop until pups become more effective at retaining heat (Hahn, 1956; Spiers & Adair, 1986; Taylor, 1960).…”

Section: Discussionmentioning

confidence: 99%

Thermogenesis, myoclonic twitching, and ultrasonic vocalization in neonatal rats during moderate and extreme cold exposure.

Blumberg¹,

Stolba²

1996

Behavioral Neuroscience

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Physiological and behavioral responses of 2- and 7-8-day-old rats were monitored during moderate and extreme cold exposure. During moderate cold exposure (30 degrees C < or = air temperature < or = 32.5 degrees C), pups at both ages increased heat production, maintained an elevated interscapular temperature, and maintained baseline levels of myoclonic twitching, a behavior commonly associated with active sleep. During extreme cold exposure (21 degrees C < or = air temperature < or = 25 degrees C), pups at both ages continued producing metabolic heat, but now exhibited pronounced decreases in interscapular temperature and decreased rates of myoclonic twitching. Furthermore, the 7-8-day-old pups exhibited significant increases in ultrasound production, and males vocalized more than females. These results suggest the presence of a narrow subthermoneutral zone in neonates in which nonshivering thermogenesis is regulated and sleep-related behaviors are protected.

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