Brønsted Acid-Mediated Multicomponent One-Pot Approach to Direct Construction of 4-Aryl-hydrocoumarin Derivatives

Sustainable Sulfonic Acid Functionalized Tubular Shape Mesoporous Silica as a Heterogeneous Catalyst for Selective Unsymmetrical Friedel–Crafts Alkylation in One Pot

“…Moreover, based on previous studies, possible reaction mechanisms involving in situ generated Brønsted acid potentially played the role of the active catalyst. 14 …”

“…It is interesting to bridge the gap between homogeneous and heterogeneous catalysis via the controllable construction of a heterogeneous catalyst containing defined active sites. The industrial production of unsymmetrical polyarylated alkanes involves the usage of precious metal complexes involving various cross-coupling reactions with prefunctionalized starting materials and demands Grignard conditions ( Scheme 1 A), 13 and also includes homogeneous Lewis acid or Brønsted acid catalyzed FC reaction using electron-rich arenes, 14 and high stoichiometry of corrosive acids such as sulfuric acid to afford polyarylated alkanes ( Scheme 1 A). 1 Consequently, several methods have also been reported using solid acidic catalysts, and ionic liquids have been employed to accomplish this typical FC reaction ( Scheme 1 B).…”