Bronchospasm caused by intravenous hydrocortisone sodium succinate (Solu-Cortef) in aspirin-sensitive asthmatics

Dajani, Basem M.; Sliman, N A; Shubair, Kandil S.; Hamzeh, Yousef

doi:10.1016/0091-6749(81)90184-6

Cited by 80 publications

(29 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present patient had aspirin-induced asthma. Corticosteroid-induced bronchospasms are more commonly seen in asthmatics with a history of an allergy to aspirin, and betamethasone has been suggested to be an alternative agent in such patients (7,8). After starting betamethasone, our patient's eosinophilia and cardiac symptoms rapidly disappeared.…”

Section: Discussionmentioning

confidence: 67%

Acute Coronary Syndrome Caused by Coronary Vasospasms Associated with Churg-Strauss Syndrome: Effects of Betamethasone Therapy

et al. 2014

View full text Add to dashboard Cite

A 42-year-old woman with a history of aspirin-induced asthma was admitted with severe chest pain. Emergency coronary angiography revealed coronary artery spasms. The administration of vasodilators did not suppress the anginal symptoms, and the differential white blood cell count continued to show eosinophilia. The patient's symptoms of aspirin-induced asthma, eosinophilia and other allergic states led to the diagnosis of Churg-Strauss syndrome (CSS). After starting betamethasone therapy, the eosinophilia and cardiac symptoms rapidly disappeared. Although coronary vasospasms related to CSS are rare, the present case suggests that a differential white blood cell count should be obtained in patients with refractory coronary vasospasms.

show abstract

Section: Discussionmentioning

confidence: 67%

Acute Coronary Syndrome Caused by Coronary Vasospasms Associated with Churg-Strauss Syndrome: Effects of Betamethasone Therapy

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In some cases of negative skin prick tests, idiosyncrasy similar to reactions to salicylic acid was suspected. 9 Furthermore, among adverse reactions to glucocorticoids, anaphylaxis induced by additives such as carboxymethylcellulose has also been reported. 10 However, an increasing number of patients with positive skin tests (prick and intradermal tests) to glucocorticoids suggests that immediate type hypersensitivity to glucocorticoids occurs.…”

Section: Discussionmentioning

confidence: 99%

Anaphylaxis Induced by Glucocorticoids

Erdmann¹,

Abuzahra²,

Schroeder³

et al. 2005

The Journal of the American Board of Family Medicine

View full text Add to dashboard Cite

Glucocorticoids are frequently used to treat allergic reactions. Therefore, allergic reactions to systemic glucocorticoids in particular are considered most unlikely and are not well known. We report on a 23-year-old woman with atopic dermatitis who had an anaphylactic reaction after oral administration of prednisolone. On treatment with epinephrine, antihistamines and volume symptoms resolved. Skin testing with a panel of glucocorticoids showed immediate type reactions to prednisolone, prednisolone hydrogen succinate, prednisone, and betamethasone dihydrogen phosphate. In challenge testing the patient tolerated methyl prednisolone and dexamethasone. There is increasing evidence that true allergic immediate type reactions to glucocorticoids exist. The severity of the reaction can vary from a rash to anaphylaxis. However, a patient sensitized to one or a group of glucocorticoids does not have to refrain from all types of glucocorticoids. Careful challenge testing is by far the best way to select glucocorticoids that are safe for future treatment. Clinicians should be aware that allergic reactions to glucocorticoids can occur and that worsening of symptoms does not always mean treatment failure. (J Am Board Fam Pract 2005;18:143-6.)Since the early 1950s, glucocorticoids have been used extensively for pharmacotherapy. Glucocorticoids are applied topically, orally, or intravenously and, if administered in higher doses, show immunosuppressive, antiproliferative, anti-inflammatory, and antiallergic effects.1 The antiallergic properties of glucocorticoids would seem to contradict their capacity to induce allergic reactions. However, a few severe adverse reactions, including life-threatening reactions caused by systemic glucocorticoids, have been reported over the past decades.2-6 Because the risk of anaphylactic reactions caused by glucocorticoids is not taken into consideration by most clinicians, severe complications may occur, particularly in the treatment of status asthmaticus or in anaphylactic reactions attributable to high doses (ie, if increasing symptoms are thought to be caused by insufficient therapy, even higher doses of glucocorticoids may be applied).We report a patient with an immediate and delayed type hypersensitivity to several glucocorticoids, the diagnostic work-up, including challenge testing, and the options for future treatment with glucocorticoids in patients with glucocorticoid allergy. Case ReportA 23-year-old woman was prescribed prednisolone (Decortin H) because of worsening of atopic dermatitis. Thirty minutes after taking the first oral dose of 40 mg of prednisolone, she developed palmoplantar paraesthesia, tightness of the chest, dizziness, and nausea, and she finally collapsed. In the emergency department, she was treated with epinephrine, antihistamines, and fluid; however, no glucocorticoid was applied because of the clinical history. Within a few hours all symptoms resolved. Two years before at the dentist's office, the patient had shown the same symptoms, albeit less severe, 15 minut...

show abstract

“…İlaca bağlı faktör olarak olarak kortikosteroidin arjinine bağlanma yeteneği, kişiye bağlı faktörler ise; derinin alkaliliğinin artması (ter, deri enfeksiyonları, venöz staz, atopik dermatit, irritan kontakt dermatit), nonsteroid hipersensitivitesi, tekrarlayan yüksek doz kortikosteroid alımı gerektiren durumlar (astım, nefrit, renal transplan- ---------tasyon) olarak belirlenmiş (12). Erken tip kortikosteroid allerjisinin nonsteroid antienflamatuvar ilaç allerjisi olan astım hastalarında daha sık gözlendiğini bildiren olgu sunumları mevcuttur (13)(14)(15)(16). Bizim olgumuzda da nonsteroid antienflamatuvar ilaçlarla alevlenen havayolu hastalı-ğı olup bunu desteklemektedir.…”

Section: Olgu Sunumuunclassified

Hypersensitivity Reaction Due to Oral Methylprednisolone in a Patient with Nonsteroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease

Terzioğlu

Öztürk

Durmus

et al. 2019

Asthma Allergy Immunol

View full text Add to dashboard Cite

ÖZKortikosteroide bağlı hipersensitivite reaksiyonu yaygın kullanılmasına rağmen nadir gözlenmektedir. Kortikosteroidlerle duyarlanma nasal, aerolizer, paranteral, oral ve topikal uygulamalar gibi birçok yoldan oluşabilmektedir. Gecikmiş tip hipersensitivite reaksiyonları genellikle topikal steroid uygulama sonrası görülürken, erken tip hipersensitivite reaksiyonu ise genelikle sistemik uygulama sonrası ortaya çıkar ve IgE aracılı tip 1 reaksiyondur. Olgu bazında yayınlar incelendiğinde kortikosteroide bağlı IgE aracılı tip 1 hipersensitive reaksiyonunun nonsteroid antienflamatuvar ilaçlarla alevlenen havayolu hastalığı olan hastalarda daha fazla gözlendiği dikkati çekmiştir. Biz de 32 yaşında nonsteroid antienflamatuvar ilaçlarla alevlenen havayolu hastalığı bulunan ve metilprednizolona bağlı hipersensitivite reaksiyonu gelişen hastamızı sunmak istedik. ABSTRACTHypersensitivity reactions caused by corticosteroids are rarely seen, despite their widespread use. Sensitization with corticosteroids can occur through many routes such as nasal, aerosol, parenteral, oral and topical. Delayed allergic reactions to topically applied glucocorticoids are frequently observed but type 1 (immediate) allergic reactions to systemic glucocorticoids are very rare. When case-based publications were examined, it was noticed that corticosteroid-associated IgE-mediated type 1 hypersensitivity reactions were more common in patients with nonsteroidal antiinflammatory drug-exacerbated respiratory diseases (NERD). We present a 32-year-old patient with nonsteroidal anti-inflammatory drug-exacerbated airway disease and a hypersensitivity reaction due to methylprednisolone.

show abstract

Bronchospasm caused by intravenous hydrocortisone sodium succinate (Solu-Cortef) in aspirin-sensitive asthmatics

Cited by 80 publications

References 5 publications

Acute Coronary Syndrome Caused by Coronary Vasospasms Associated with Churg-Strauss Syndrome: Effects of Betamethasone Therapy

Acute Coronary Syndrome Caused by Coronary Vasospasms Associated with Churg-Strauss Syndrome: Effects of Betamethasone Therapy

Anaphylaxis Induced by Glucocorticoids

Hypersensitivity Reaction Due to Oral Methylprednisolone in a Patient with Nonsteroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease

Contact Info

Product

Resources

About