Bronchoscopic Therapies for Peripheral Lung Malignancies

Hsia, David; Musani, Ali I.

doi:10.1016/j.ccm.2017.11.014

Cited by 5 publications

(4 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EBUS-TBNA shows a pooled sensitivity of approximately 90% for staging non-small-cell lung cancer and 85% for intrathoracic lymph nodal metastases from extrathoracic malignancies 18 , 29 , and there is excellent agreement (100%) between EBUS-TBNA and mediastinoscopy for mediastinal staging 20 . Moreover, guided bronchoscopy, including VBN, ultrathin bronchoscopy, ENB, guiding sheaths and radial EBUS, provides assistance in navigating towards peripheral lung lesions, with 70% of the pooled diagnostic yield for peripheral nodule sampling 30 . PEs is the most common complication of pulmonary lesions, and diagnosis based on pulmonary lesions might indicate a diagnosis of concurrent PE.…”

Section: Discussionmentioning

confidence: 99%

The efficiency of a clinical pathway to guide combined applications of interventional pulmonology in undiagnosed pleural effusions

Liu

Geng

et al. 2022

Sci Rep

View full text Add to dashboard Cite

The diagnostic procedure of pleural effusion (PEs) is challenging due to low detection rates and numerous aetiologies. Hence, any attempt to enhance diagnosis is worthwhile. We present a clinical pathway to guide combined application of interventional pulmonology (IP) for tracing causes of undiagnosed PEs. Subjects with undiagnosed PEs were identified in the Hospital Information System of Dalian Municipal Central Hospital from January 1, 2012, to December 31, 2018. Eligible subjects were divided into a group of combined tests and a group of medical thoracoscopy (MT). Optimal and subsequent diagnostic tests were performed depending on the guidance of the clinical pathway by matching profitable chest lesions with the respective adaptation. As the guidance of clinical pathway, common bronchoscopy would be preferentially selected if pulmonary lesions involved or within the central bronchus, EBUS-TBNA was favoured when pulmonary lesions were adjacent to the central bronchus or with the enlarged mediastinal/hilar lymph nodes, guided bronchoscopy would be preferred if pulmonary nodules/masses were larger than 20 mm with discernible bronchus signs, CT-assisted transthoracic core biopsy was preferred if pulmonary nodules were less than 20 mm, image guided cutting needle biopsy was the recommendation if the pleural thickness was larger than 10 mm and pulmonary lesions were miliary. MT was preferred only when undiagnosed PEs was the initial symptom and pulmonary lesions were miliary or absent. A total of 83.57% cases of undiagnosed PEs were eligible for the clinical pathway, and 659 and 216 subjects were included in the combined tests and MT groups, respectively, depending on the optimal recommendation of the clinical pathway. The total diagnostic yields in the combined tests and MT groups were 95.99% and 91.20%, respectively, and the difference in total diagnostic yield was statistically significant (χ2 = 7.510, p = 0.006). Overall, clinical pathway guidance of the combined application of IP is useful for tracing the causes of undiagnosed PEs. The diagnostic yield of undiagnosed PEs is significantly increased compared with that of MT alone.

show abstract

Section: Discussionmentioning

confidence: 99%

The efficiency of a clinical pathway to guide combined applications of interventional pulmonology in undiagnosed pleural effusions

Liu

Geng

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Stenting is at the edge of a new era with customised/3-dimensional printed, biodegradable and bioactive stents [4]. Therapeutic bronchoscopy for peripheral and inoperable early stage lung cancer is one of the most promising areas for research and clinical applications, which could eventually compete one day with surgical resection or stereotactic radioablative therapy [5]. The minimally invasive diagnostic and therapeutic approach to pleural disease has also been fascinating.…”

mentioning

confidence: 99%

Interventional pulmonology: between ambition and wisdom

Dutau¹,

Feller‐Kopman

2020

Eur Respir Rev

View full text Add to dashboard Cite

show abstract

“…These therapies include radiofrequency ablation (RFA), microwave ablation, cryoablation, laser ablation, brachytherapy, photodynamic therapy, vapor ablation, and direct injection of chemotherapeutics. Hsia and Musani have recently reviewed the potential benefits and limitations of these different modalities [15]. Several of these therapies, notably RFA, are already in clinical practice through percutaneous CT-guidance, though have been limited by a relatively high (20%) pneumothorax rate.…”

mentioning

confidence: 99%

“…It has already been shown that incomplete local ablation appears to be directly linked with tumor size [16]. A review of several studies showed that complete ablation was more successful (with a range of 78-96%) when the tumor was <2 cm [15]. In addition to ablation size, adequate margins of ablation are critical to success.…”

mentioning

confidence: 99%