Bronchoscopic techniques in diagnosis and staging of lung cancer

Herth, Felix J.F.

doi:10.1183/20734735.021510

Cited by 16 publications

(12 citation statements)

References 103 publications

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“…5,6,24 Besides, the yield of eBB is also affected by several other factors like necrotic tissue overlying the biopsy-site, crushing artifact of biopsied tissue in the bronchoscope channel, size of the biopsied tissue, experience of the operator (bronchoscopist) and the number of biopsy samples taken. 5,[25][26][27][28] the diagnostic yield for patients with exophytic growth was higher compared to patients with submucosal/mucosal infiltrative lesion (83.7% vs. 57%). this is in agreement with study by Kacar et al 25 that reported similar yields for exopytic growth (86.4%) and infiltrative/peribronchial lesions (47.2%).…”

Section: Discussionmentioning

confidence: 99%

Complications and predictors of diagnostic yield of endobronchial forceps biopsy in visible lesions

et al. 2019

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Background: Fiberoptic bronchoscopy is an important and relatively safe procedure for evaluation of various pulmonary diseases. Endobronchial forceps biopsy is commonly performed sampling technique for visible lesions in tracheobronchial tree. Diagnostic yield of biopsy depends upon lesion type and the number of biopsy samples taken. This study aimed to evaluate the complications and diagnostic yield of endobronchial forceps biopsy in visible lesions and correlate the number of biopsy samples taken with the yield. Methods: This was an observational study conducted at two tertiary care hospitals in Chitwan; Chitwan Medical College Teaching Hospital and B P Koirala Memorial Cancer Hospital. One hundred and forty patients who underwent endobronchial forceps biopsy of bronchoscopically visible lesions were included. Complications and diagnostic yield of the biopsy samples and its correlation with number of biopsies taken were evaluated. Results: The common complications observed were transient drop in saturation > 4% (22%) and mild bleeding (9.9%). The net diagnostic yield was 67.4% that significantly improved with an increase in the number of biopsies taken. The yield was better for exophytic growths compared to submucosal/ mucosal lesions (83.7% vs. 57%, OR = 8.1 (2.2 – 29.9), P<0.001). The association of improved yield with increased number of biopsy was more pronounced in exophytic growths compared to submucosal/mucosal lesions. Conclusion: Endobronchial forceps biopsy is a safe procedure that gives a good diagnostic yield in bronchoscopically visible lesions, provided adequate number of biopsy sample are taken. The probability of getting a positive yield is high in exophytic growths.

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Section: Discussionmentioning

confidence: 99%

Complications and predictors of diagnostic yield of endobronchial forceps biopsy in visible lesions

et al. 2019

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“…While studies performed on biopsies are most relevant to humans, they are limited by the lifetime span of the sample ~5 days. Moreover, the diagnostic selectivity of bronchoscopy strongly depends on lesion size and for lesions <3 cm the selectivity varies in range 14–50% and could be more than 50% for lesions > 3 cm implying that lung cancer tends to be detected at an advanced stage 37 – 40 . Also, because of these reasons, until now, there has been no accepted explanation of the differences in fluorescence for normal and cancerous tissue in the lungs 4 , 41 , 42 .…”

Section: Introductionmentioning

confidence: 99%

Health state dependent multiphoton induced autofluorescence in human 3D in vitro lung cancer model

Kilin

Mas²,

Constant

et al. 2017

Sci Rep

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Lung diseases pose the highest risk of death and lung cancer is a top killer among cancers with a mortality rate up to 70% within 1 year after diagnosis. Such a fast escalation of this cancer development makes early diagnosis and treatment a highly challenging task, and currently there are no effective tools to diagnose the disease at an early stage. The ability to discriminate between healthy and tumorous tissue has made autofluorescence bronchoscopy a promising tool for detection of lung cancer; however, specificity of this method remains insufficiently low. Here, we perform autofluorescence imaging of human lung cancer invading a human functional airway using an in vitro model of Non Small Cell Lung Cancer which combines a reconstituted human airway epithelium, human lung fibroblasts and lung adenocarcinoma cell lines, OncoCilAir™. By using two-photon laser induced autofluorescence microscopy combined with spectrally resolved imaging, we found that OncoCilAir™ provides tissue’s health dependent autofluorescence similar as observed in lung tissue in patients. Moreover, we found spectral and intensity heterogeneity of autofluorescence at the edges of tumors. This metabolic related heterogeneity demonstrates ability of tumor to influence its microenvironment. Together, our result shows that OncoCilAir™ is a promising model for lung cancer research.

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“…21 The changes with peribronchial tumours or with submucosal infiltration are often subtly, the airways should be examined closely for characteristic changes, such as erythema, loss of bronchial markings and nodularity of the mucosal surface. Central lesions are usually sampled with a combination of bronchial washes, bronchial brushings and endobronchial biopsies.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological profile and yield of fibreoptic bronchoscopy in 30 cases of lung carcinoma

2017

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Background: The study aims to identify the diagnostic yield of bronchoscopy along with clinico-pathological profile of 30 confirmed cases of lung cancer during a 6-months period.Methods: A retrospective analysis was conducted on the diagnostic yield bronchial brushing (BB), bronchoalveolar lavage (BAL) and brush biopsy specimens obtained at fibre-optic bronchoscopy for patients with lung cancer and their clinico-pathological characteristics studied.Results: Of 30 patients who underwent fibre-optic bronchoscopy examination brush cytology was diagnostic in 17 patients (68%) brush biopsy in 5 patients (20%) and BAL cytology in 4 patients (16%) with adenocarcinoma in 13 patients (43%), non-small cell carcinoma in 1 (3%), large cell carcinoma in 1 (3%), squamous cell carcinoma in 5 (16%), small cell carcinoma in 5 (16%). The most common Symptom was cough in 25 (83%) followed by chest pain in 22 (73.3%), breathlessness in 14 (46.6%), fever in 13 (43.3%), anorexia in 11 (36.6%), weight loss in 10 (33.3%), hoarseness of voice and haemoptysis in 5 (16.6%) and dysphagia in 1 (3.3%).Conclusions: In bronchoscopic procedure the highest yield is of brush cytology with adenocarcinoma being the most common type with presenting complaint of cough and chest pain. The prevalence of lung cancer is more common among males and commonly being located in right upper lobe.

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Bronchoscopic techniques in diagnosis and staging of lung cancer

Cited by 16 publications

References 103 publications

Complications and predictors of diagnostic yield of endobronchial forceps biopsy in visible lesions

Complications and predictors of diagnostic yield of endobronchial forceps biopsy in visible lesions

Health state dependent multiphoton induced autofluorescence in human 3D in vitro lung cancer model

Clinicopathological profile and yield of fibreoptic bronchoscopy in 30 cases of lung carcinoma

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