Bronchoscopic instillation of liposomal amphotericin B in management of nonresponding endobronchial mucormycosis

Loganathan, N; Kalai, Umasankar; Hadda, Vijay; Guleria, Randeep; Madan, Karan

doi:10.4103/0970-2113.201303

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…Bronchoscopic bronchoalveolar lavage has become an important technique in the treatment of severe lung infections. Compared with traditional treatments, bronchoalveolar lavage flushes out the mucous secretions obstructing the bronchi, delivers drugs directly to the infected lung tissues, and ensures that the topical drug concentration is in the range that can effectively kill the pathogens [ 14 ]. During topical administration of drugs through the bronchoscopic sheath, efforts should be made to avoid delivering drugs into uninfected bronchial and lung tissues besides the target lesions.…”

Section: Discussionmentioning

confidence: 99%

Application and evaluation of topical amphotericin B for the treatment of respiratory fungal infections

Cui,

Zhao

2024

BMC Infect Dis

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Background In recent years, the prevalence of respiratory fungal diseases has increased. Polyene antifungal drugs play a pivotal role in the treatment of these conditions, with amphotericin B (AmB) being the most representative drug. This study aimed to evaluate the efficacy and safety of topical administration of AmB in the treatment of respiratory fungal infections. Methods We conducted a retrospective study on hospitalized patients treated with topical administered AmB for respiratory fungal infections from January 2014 to June 2023. Results Data from 36 patients with invasive pulmonary fungal infections treated with topical administration of AmB were collected and analyzed. Nebulization was administered to 27 patients. After the treatment, 17 patients evidenced improved conditions, whereas 10 patients did not respond and died in the hospital. One patient experienced an irritating cough as an adverse reaction. Seven patients underwent tracheoscopic instillation, and two received intrapleural irrigation; they achieved good clinical therapeutic efficacy without adverse effects. Conclusion The combined application of systemic antifungal treatment and topical administration of AmB yielded good therapeutic efficacy and was well-tolerated by the patients. Close monitoring of routine blood tests, liver and kidney function, and levels of electrolytes, troponin, and B-type natriuretic peptide supported this conclusion.

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Section: Discussionmentioning

confidence: 99%

Application and evaluation of topical amphotericin B for the treatment of respiratory fungal infections

Cui,

Zhao

2024

BMC Infect Dis

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“…Previous studies reported rare cases of Mucormycosis with endobronchial [ [20] , [21] , [22] ] and mediastinal [ 23 , 24 ] involvements. Our patient presented with a less seen situation: the simultaneity of a mediastinal mass on one side and an endobronchial mass on the other, and this co-occurrence and the patient's characteristics, especially mediastinal lymphadenopathy led to primary misdiagnosis of malignancy.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous endobronchial and mediastinal mucormycosis in a patient with Diabetes Mellitus and SARS-CoV-2: A case report and literature review

Sayyadi,

Salajegheh,

Dalfardi

et al. 2024

Heliyon

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“…Endobronchial fungal infections due to Aspergillus , Mucor , Candida , Coccidioides , and Histoplasma species are well described in immunocompromised patients but can also occur in apparently immunocompetent individuals also. [ 6 7 ] I would suggest bronchoscopic samples to be processed for stain and cultures for mycobacteria and fungi in addition to histopathology.…”

Section: Salient Features Of the Case And Differential Diagnosismentioning

confidence: 99%

A 44-year-old man with hemoptysis

et al. 2018

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A 44-year-old man with background history of diffuse cutaneous systemic sclerosis and dilated cardiomyopathy receiving immunosuppressive medications, presented with a 2-month history of cough and streaky hemoptysis. Clinicoradiological features were consistent with an endotracheal mass. Subsequently, the patient developed nodular skin lesions and the tracheal mass increased in size causing central airway obstruction. This clinicopathologic conference discusses the clinical and radiological differential diagnoses of such a clinical presentation and their management options.

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Bronchoscopic instillation of liposomal amphotericin B in management of nonresponding endobronchial mucormycosis

Cited by 8 publications

References 5 publications

Application and evaluation of topical amphotericin B for the treatment of respiratory fungal infections

Application and evaluation of topical amphotericin B for the treatment of respiratory fungal infections

Simultaneous endobronchial and mediastinal mucormycosis in a patient with Diabetes Mellitus and SARS-CoV-2: A case report and literature review

A 44-year-old man with hemoptysis

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