Bronchoscopic findings of extramural lung cancer invading the subepithelium or submucosa

Gemma, Akihiko; Takenaka, Kiyoshi; Andou, Masahiro; Yamada, Kouiti; Hasegawa, Kouichi; Tachibana, Masahito; H, Iwanami; Sakonji, Mitsuaki; Tsuboi, Eitaka; Kudoh, Shoji; Niitani, Hisanobu

doi:10.1016/0169-5002(94)00405-c

Cited by 6 publications

(2 citation statements)

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“…Deep infiltration into the airway mucosa was more frequently observed in patients with centrally located lung cancers than in those with hilar lymph node metastasis (14). It has also been reported that subepithelial and submucosal invasion in the bronchus are closely correlated with mediastinal lymph node metastasis (15). In this study, the incidence of mediastinal lymph node metastasis was rare in patients with centrally located lung cancer directly infiltrating the central airway compared with patients with hilar lymph node metastasis.…”

Section: Discussionsupporting

confidence: 44%

Impact of Central Airway Infiltration Type in Primary Lung Cancer Patients Treated With Sleeve Lobectomy

Tsukioka

Izumi

Komatsu

et al. 2022

In Vivo

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Background/Aim: There are two types of lung cancer cell infiltration into the central airway. One is when a centrally located lung cancer directly infiltrates the central airway and the other is when cancer cells in the metastatic hilar lymph node infiltrate the central airway. We aimed to identify the impact of central airway infiltration type on the clinical features of patients undergoing sleeve lobectomy. Patients and Methods: The clinical courses of 58 primary lung cancer patients who underwent sleeve lobectomy between January 2010 and December 2020 were investigated. Results: Primary tumors directly infiltrated into the central airway in 42 patients, whereas 16 patients had infiltration of cancer cells from the metastatic hilar lymph node. Primary tumor infiltration was a poor prognostic factor according to both univariate (p=0.016) and multivariate analyses (p=0.042). Operation times (p=0.240) and incidences of adverse events (p=0.926) were not associated with the type of central airway infiltration. Conclusion: The type of airway infiltration was an independent poor prognostic factor after sleeve lobectomy in primary lung cancer patients. Our findings may guide the selection of optimal treatments for this patient population.There are two ways in which lung cancer cells infiltrate into the central airway. One involves a centrally located lung cancer directly infiltrating the central airway. The other is when cancer cells in the metastatic hilar lymph node infiltrate the central airway. Sleeve lobectomy is required to completely remove centrally located lung cancers or lung cancers with hilar lymph node metastasis and to preserve the peripheral lung tissue. The impacts of central airway infiltration type on surgical methods, postoperative courses, and prognosis in patients undergoing sleeve lobectomy have never been investigated.This study aimed to identify the impact of central airway infiltration type on the clinical features and outcomes of patients undergoing sleeve lobectomy.

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Section: Discussionsupporting

confidence: 44%

Impact of Central Airway Infiltration Type in Primary Lung Cancer Patients Treated With Sleeve Lobectomy

Tsukioka

Izumi

Komatsu

et al. 2022

In Vivo

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“…In patients with submucosal type tumors, it is very difficult to distinguish between bronchial infiltration and compression by a tumor or lymph node. 11 Endobronchial ultrasound (EBUS) was recently developed, which has proven to be an accurate diagnostic tool for evaluating the airway involvement of central intrathoracic tumors. 12 Therefore, it is expected that the decision to perform lobectomy with or without bronchoplasty, or pneumonectomy, will be determined with the aid of preoperative EBUS examination.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Tumor Extension Requiring Bronchoplasty and Pneumonectomy in Patients with Lung Cancer and Positive Bronchoscopic Findings

et al. 2006

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Quadri endoscopici, tecniche di prelievo e resa diagnostica nelle lesioni centrali

Gasparini

Cavaliere

Pneumologia Interventistica

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Bronchoscopic findings of extramural lung cancer invading the subepithelium or submucosa

Cited by 6 publications

References 1 publication

Impact of Central Airway Infiltration Type in Primary Lung Cancer Patients Treated With Sleeve Lobectomy

Impact of Central Airway Infiltration Type in Primary Lung Cancer Patients Treated With Sleeve Lobectomy

Characteristics of Tumor Extension Requiring Bronchoplasty and Pneumonectomy in Patients with Lung Cancer and Positive Bronchoscopic Findings

Quadri endoscopici, tecniche di prelievo e resa diagnostica nelle lesioni centrali

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