Bronchopulmonary dysplasia – trends over three decades

Zysman-Colman, Zofia; Tremblay, Geneviève; Bandeali, Suhair; Landry, Jennifer

doi:10.1093/pch/18.2.86

Cited by 97 publications

(70 citation statements)

References 27 publications

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“…The demographic characteristics and frequency of respiratory interventions and BPD in our cohort are similar to other cohorts from this era. 24,25 Infants admitted to the neonatal intensive care unit (NICU) often require respiratory support 26 and the risk for BPD and long-term adverse effects on pulmonary function is generally higher the earlier the infant is born. 11 …”

Section: Discussionmentioning

confidence: 99%

Relationship between Epigenetic Maturity and Respiratory Morbidity in Preterm Infants

Knight

Smith

Conneely

et al. 2018

The Journal of Pediatrics

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Objective To assess associations between epigenetic maturity of extremely preterm babies (born at less than 28 weeks of gestation), neonatal interventions, and respiratory outcomes, including the administration of surfactant and postnatal corticosteroids, duration of assisted ventilation, and development of bronchopulmonary dysplasia (BPD). Study design DNA was extracted from neonatal blood spots collected after birth from 143 extremely preterm infants born 1991–1992 in Victoria, Australia and used to determined DNA methylation (DNAm). A DNAm based gestational age was determined using our previously published method. The residual of DNAm gestational age and clinically estimated gestational age (referred to as “gestational age acceleration”) was used as a measure to assess developmental maturity. Associations between gestational age acceleration and respiratory interventions and morbidities were determined. Results Infants with higher gestational age acceleration were less likely to receive surfactant (P =.009) or postnatal corticosteroids (P = .008), had fewer days of assisted ventilation (P = .01), and had less BPD (P = .02). Respiratory measures are known to correlate with gestational age; however, models comparing each with clinically estimated gestational age were improved by the addition of the gestational age acceleration measure in the model. Conclusions Gestational age acceleration correlates with respiratory interventions and outcomes of extremely preterm babies. Surfactant and postnatal corticosteroid use, assisted ventilation days, and BPD rates were all lower in babies who were epigenetically more mature than their obstetrically estimated gestational age. This suggests that gestational age acceleration is a clinically relevant metric of developmental maturity.

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Section: Discussionmentioning

confidence: 99%

Relationship between Epigenetic Maturity and Respiratory Morbidity in Preterm Infants

Knight

Smith

Conneely

et al. 2018

The Journal of Pediatrics

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“…It is characterized by arrest in lung development with severe impairment of alveolar septation and vascular development, leading to the development of pulmonary hypertension. It is well known that male premature neonates are more susceptible than females for the development of many prematurity related morbidities including BPD (Binet et al, 2012; Costeloe et al, 2000; Kraybill et al, 1989; O'Shea et al, 2012; Trembath and Laughon, 2012; Zysman-Colman et al, 2013), however, the underlying molecular mechanism(s) are not completely understood.…”

Section: Introductionmentioning

confidence: 99%

Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro : Role of Hif-1α

Zhang

Jiang

Wang

et al. 2017

Toxicology and Applied Pharmacology

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Male premature neonates are more susceptible than females to the development of bronchopulmonary dysplasia (BPD). The reasons underlying sexually dimorphic outcomes in premature neonates are not known. GDF15 (Growth and differentiation factor 15) is a secreted cytokine and plays a role in cell proliferation, apoptosis, and angiogenesis. In this study, we sought to elucidate the sex-specific expression of Gdf15 in the lung in vivo in neonatal hyperoxic lung injury and its regulation by Hif-1α, and to delineate the differences in GDF15 expression in male and female human umbilical venous endothelial cells in an in vitro model of oxygen toxicity. Following hyperoxia exposure (95% FiO2, PND (postnatal day 1-5: saccular stage of lung development), neonatal male mice (C57BL/6) show increased GDF15 and decreased HIF-1α expression compared to female mice. For the in vitro experiments, male and female HUVECs were exposed to room air condition (21% O2, 5% CO2) or in hyperoxia condition (95% O2, 5% CO2) for up to 72 h. Male HUVECs had greater expression of GDF15 mRNA and protein. To study the inter-relationship between GDF15 and HIF-1α, we measured the expression of GDF15 in H441 cells after HIF-1α knockdown using promoter dual luciferase reporter assay, which showed that HIF-1α and GDF15 expression are inversely related under normoxia and hyperoxia. The results indicate that sex differences exist in the expression and modulation of GDF15 by HIF-1α in neonatal hyperoxic injury both in vivo and in vitro. These differences could explain in part the mechanisms behind sex-specific differences in BPD.

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“…Accordingly, male sex is associated with a greater risk of neonatal mortality and respiratory illness including BPD (5)(6)(7). Previous studies have indicated that this "male disadvantage" following preterm birth is a result of delayed lung maturation (8), but the basis for the delayed maturation is not completely understood.…”

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confidence: 99%

Respiratory adaptation and surfactant composition of unanesthetized male and female lambs differ for up to 8 h after preterm birth

et al. 2015

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Bronchopulmonary dysplasia – trends over three decades

Abstract: Mortality from BPD has improved over the past three decades despite significant trends toward more pronounced prematurity and lower birth weights.

Cited by 97 publications

References 27 publications

Relationship between Epigenetic Maturity and Respiratory Morbidity in Preterm Infants

Relationship between Epigenetic Maturity and Respiratory Morbidity in Preterm Infants

Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro : Role of Hif-1α

Respiratory adaptation and surfactant composition of unanesthetized male and female lambs differ for up to 8 h after preterm birth

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