Bronchopulmonary dysplasia in neonates born to mothers with preeclampsia: Impact of small for gestational age

Abstract

Background and objectivesSmall for gestational age and preeclampsia have both been described as risk factors for bronchopulmonary dysplasia in preterm neonates, but their respective role in the occurrence of bronchopulmonary dysplasia is debated. We evaluated the relation between small for gestational age and bronchopulmonary dysplasia in neonates born to mothers with preeclampsia. We hypothesized that low birth weight is still associated with bronchopulmonary dysplasia in this homogeneous population.MethodsRetrospective single-center cohort study including 141 neonates born between 24 and 30 weeks’ gestation to mothers with preeclampsia. The main outcome measure was moderate to severe bronchopulmonary dysplasia at 36 weeks’ postmenstrual age. Neonates born small for gestational age (birthweight < 10th percentile on the AUDIPOG curves) were compared to those with appropriate birthweight for gestational age by bivariable analyses and logistic regression models, estimating odds ratios (ORs) and 95% confidence intervals (CIs).ResultsBronchopulmonary dysplasia rates were 61.5% (32/52) and 27.4% (20/73) for small for gestational age and appropriate birthweight for gestational age neonates (p < .001). On adjustment for gestational age and other confounding factors, the risk of moderate to severe bronchopulmonary dysplasia was greater for small for gestational age than appropriate birthweight for gestational age neonates (adjusted OR = 5.9, 95% CI [2.2–15.4]), as was the composite outcome death or moderate to severe bronchopulmonary dysplasia (adjusted OR = 4.7, 95% CI [1.9–11.3]).ConclusionsSmall for gestational age was associated with bronchopulmonary dysplasia in very preterm neonates born to mothers with preeclampsia.Registration numberCNIL no. 1747084.

Anemia, nutrition, and ambulatory oxygen weaning in a cohort of oxygen‐dependent premature infants

“…The risk factors in these OD preterms cohort study are similar to that found in the literature, with the predominance of male patients and a history of maternal infection in more than 28% of cases, followed by toxemia (22%) and premature rupture of membranes (18.4%) 14–17 …”

“…The risk factors in these OD preterms cohort study are similar to that found in the literature, with the predominance of male patients and a history of maternal infection in more than 28% of cases, followed by toxemia (22%) and premature rupture of membranes (18.4%). [14][15][16][17] Regarding postnatal history, almost half of our patients received invasive ventilation (51.4%), with a median duration of 2 days. This highlights the need to avoid this type of ventilatory support as much as possible, favoring strategies such as CPAP and/or nasal ventilation from the delivery room.…”

Anemia, nutrition and ambulatory oxygen weaning in a cohort of oxygen-dependent premature infants.

“…The history of the OD preterm cohort in this study is similar to that found in the literature, with predominance of male patients and a history of maternal infection in more than 50% of the cases, followed by toxemia (21%) and premature rupture of membranes (6.7%) [14][15][16][17] .…”

MicroRNA-214 Prevents Pulmonary Angiogenesis and Alveolarization in Rat Models with Bronchopulmonary Dysplasia via PlGF-Dependent STAT3 Signaling Pathway

“…BPD is a respiratory condition occurring in preterm neonates and can lead to chronic respiratory problems driven by several prenatal and/or postnatal factors [20]. The known risk factors associated with BPD development in preterm neonates include small gestational age, preeclampsia, chorioamnionitis and in ltration of the chorioamnion by neutrophils [21,22]. The most likely underlying pathogenesis is the constant in ammation in lung, and thus corticosteroid, which has a strong anti-in ammatory effect, has been employed in the treatment of BPD [23].…”