Bronchopulmonary Dysplasia Frequency and Risk Factors in Very Low Birth Weight İnfants: a 3-Year Retrospective Study

Çokyaman, Turgay

doi:10.14744/nci.2019.23427

Cited by 15 publications

(23 citation statements)

References 54 publications

(44 reference statements)

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Section: Discussionsupporting

confidence: 80%

“…The risk factors in these OD preterms cohort study are similar to that found in the literature, with the predominance of male patients and a history of maternal infection in more than 28% of cases, followed by toxemia (22%) and premature rupture of membranes (18.4%). [14][15][16][17] Regarding postnatal history, almost half of our patients received invasive ventilation (51.4%), with a median duration of 2 days. This highlights the need to avoid this type of ventilatory support as much as possible, favoring strategies such as CPAP and/or nasal ventilation from the delivery room.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anemia, nutrition, and ambulatory oxygen weaning in a cohort of oxygen‐dependent premature infants

Montealegre‐Pomar

Charpak

2021

Pediatric Pulmonology

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Background: In Bogotá, Colombia, oxygen-dependent (OD) preterm infants are home discharged in Kangaroo Position, to a Kangaroo Mother Care Program (KMCP) with ambulatory oxygen, strict follow-up, and oxygen weaning protocols. Objectives:(1) To describe growth, morbimortality, and oxygen monitoring up to 6 months in OD preterm infants. (2) To explore associations between oxygen weaning, perinatal history, Hb levels, transfusions, feeding patterns, and growth.Methods: A prospective cohort study. Descriptive and multivariate analysis.Results: Recruited patients were 407 with 33 weeks median gestational age (GA).Mothers presented infections >28%, pre-eclampsia in 22%, and 80% received antenatal corticosteroids. Upon KMCP admission, median GA, chronological age, and hospital stay were 36 weeks, 21 and 17 days, respectively; 56.8% of patients had neonatal sepsis and 67.8% were admitted to the neonatal intensive care unit. At oxygen weaning, patients had a median of 54 days with oxygen, median weight 3240 g and GA 41 weeks. Median follow-up oxygen saturation was 94% with 1/64-1/2 L/min of oxygen. One-year mortality was 0.2% and attrition 20%. At 6 months, all patients had appropriate growth and 67% were breastfeeding.Multiple regression analysis showed that higher GA, Hb levels, weight gain, and exclusive breastfeeding decreased oxygen requirement while invasive ventilation and transfusions had the opposite effect (R 2 = .49). Conclusions:In OD preterm infants, there is a close relationship between days of oxygen requirement and GA, mechanical ventilation, Hb levels at discharge, transfusions, exclusive breastfeeding, and weight gain. Strict monitoring with established protocols in an ambulatory KMCP allows adequate growth and safe oxygen weaning.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Anemia, nutrition, and ambulatory oxygen weaning in a cohort of oxygen‐dependent premature infants

Montealegre‐Pomar

Charpak

2021

Pediatric Pulmonology

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“…The history of the OD preterm cohort in this study is similar to that found in the literature, with predominance of male patients and a history of maternal infection in more than 50% of the cases, followed by toxemia (21%) and premature rupture of membranes (6.7%) [14][15][16][17] .…”

Section: Discussionsupporting

confidence: 83%

Anemia, nutrition and ambulatory oxygen weaning in a cohort of oxygen-dependent premature infants.

Montealegre‐Pomar

Charpak²

2020

Preprint

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Background: In Bogotá, Colombia, oxygen-dependent (OD) preterm infants are home discharged in Kangaroo Position, to a Kangaroo Mother Care program (KMCP) with ambulatory oxygen, strict follow-up and oxygen weaning protocols. Objectives: 1) to describe growth and morbimortality up to 6 months of an OD preterm infants’ cohort. 2) to explore the association between oxygen requirement, perinatal history, Hb levels, transfusions, feeding patterns and growth. Methods: Prospective cohort study. Descriptive and multivariate analysis. Results: 445 patients were recruited with 33 weeks median gestational age (GA). 21% of mothers had preeclampsia, 50% infections and 77% received antenatal corticosteroids. Upon KMCP admission, median GA, chronological age and hospital stay were 36 weeks, 19 and 17 days, respectively; 55.6% of patients had neonatal sepsis and 66.6% were admitted to Neonatal Intensive Care Unit. Patients had on average 52 days with oxygen, a median of 3200g and 42 weeks GA at oxygen weaning. Median follow-up oxygen saturation was 94% with 0.016-0.5 l/min of oxygen. One-year mortality was 0.2% and attrition 20%. At 6 months, all patients had appropriate growth and 66% were breastfeeding. Multiple regression analysis showed that higher GA, Hb levels, weight gain, and exclusive breastfeeding decreased oxygen requirement whilst invasive ventilation and transfusions had the opposite effect (R2=0.48). Conclusions: In OD preterm infants, there is a close relationship between days of oxygen requirement and GA, mechanical ventilation, Hb levels at discharge, transfusions, exclusive breastfeeding and weight gain. Strict monitoring with established protocols in an ambulatory KMCP allows adequate growth and safe oxygen weaning.

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“…Infants with immature lung development are prone to BPD (24)(25)(26). The results of this study showed that infants with a history of neonatal asphyxia and NRDS were at higher risk of developing BPD, consistent with the results of several previous studies.…”

Section: Analysis Of Risk Factors For Bpd In Vlbwismentioning

confidence: 99%

Development and verification of a risk prediction model for bronchopulmonary dysplasia in very low birth weight infants

Cai¹,

Jiang²,

Liu³

et al. 2021

Transl Pediatr

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Background: To analyze the risk factors of bronchopulmonary dysplasia (BPD) of very low birth weight infants (VLBWIs), and to develop and verify a risk prediction model of BPD. Methods: The data of 611 VLBWIs from the neonatal intensive care unit (NICU) of a tertiary grade A hospital in Suzhou from January 2017 to September 2019 were collected. The data was randomly divided into the modeling set (451 cases) and the validation set (160 cases). Binary logistic regression was used to analyze the data, and the model was examined by a receiver operating characteristic (ROC) curve. The grouped data was used to verify the sensitivity and specificity of the model. Results: The study found that neonatal asphyxia, the positive rate of sputum culture, neonatal sepsis, neonatal respiratory distress syndrome (NRDS), blood transfusions (≥3), patent ductus arteriosus (PDA), the time of invasive mechanical ventilation, the duration of oxygen therapy, and the time of parenteral nutrition were the independent risk factors of BPD, while 1 min Apgar score was a protective factor. The model formula was Z=neonatal asphyxia * 1.229 + the positive rate of sputum culture * 1.265 + neonatal sepsis * 1.677 + NRDS * 1.848 + blood transfusions (≥3) * 1.455 + PDA * 1.835 − 1 min Apgar score * 0.25 + the time of invasive mechanical ventilation * 0.123 + the duration of oxygen therapy * 0.09 + the time of parenteral nutrition * 0.057 − 8.077. The area under the ROC curve of this model was 0.965 (95% CI: 0.946-0.983),with a sensitivity of 93.7% and a specificity of 91.3%. Verification of this prediction model showed a sensitivity of 92.9% and a specificity of 76%, demonstrating that the effects of this model were satisfactory. Conclusions:The risk prediction model had a good predictive effect for the risk of BPD in VLBWIs, and can provide a reference for preventive treatment and nursing intervention.

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Bronchopulmonary Dysplasia Frequency and Risk Factors in Very Low Birth Weight İnfants: a 3-Year Retrospective Study

Cited by 15 publications

References 54 publications

Anemia, nutrition, and ambulatory oxygen weaning in a cohort of oxygen‐dependent premature infants

Anemia, nutrition, and ambulatory oxygen weaning in a cohort of oxygen‐dependent premature infants

Anemia, nutrition and ambulatory oxygen weaning in a cohort of oxygen-dependent premature infants.

Development and verification of a risk prediction model for bronchopulmonary dysplasia in very low birth weight infants

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