Bronchopulmonary dysplasia: Clinical practices in five Portuguese neonatal intensive care units

Abstract

Resumo Com o advento do surfactante, dos corticosteróides prénatais e dos avanços na tecnologia, a sobrevida dos recém-nascidos de extremo baixo peso tem melhorado dramaticamente. As taxas de displasia broncopulmonar (DBP) variam amplamente entre unidades, e vários estudos, avaliando resultados de múltiplas intervenções, têm mostrado alguma melhoria na prevalência da DBP. A implementação de potenciais boas práticas na DBP tem sido adoptada por muitos serviços nas últimas décadas. Objectivo: Comparar cinco unidades portuguesas de cuidados intensivos neonatais no que se refere as práticas clínicas no tratamento dos recém-nascidos de mui-Abstract With the advent of surfactant, prenatal corticosteroids (PNC) and advances in technology, the survival rate of extremely low birth weight (ELBW) infants has improved dramatically. Rates of bronchopulmonary dysplasia (BPD) vary widely among neonatal intensive care units (NICUs) and many studies using multiple interventions have shown some improvement in BPD rates. Implementing potentially better practices to reduce BPD has been an effort made over the last few decades. Aim: To compare five Portuguese NICUs in terms of clinical practices in very low birth weight (VLBW) infants, in order to develop Displasia broncopulmonar: Práticas clínicas em cinco unidades de cuidados intensivos neonatais Bronchopulmonary dysplasia: Clinical practices in five Portuguese neonatal intensive care units Recebido para publicação/received for publication: 09.06.29 Aceite para publicação/accepted for publication: 09.09.08

Hypertensive Disorders during Pregnancy and Risk of Bronchopulmonary Dysplasia in Very Preterm Infants

“…17 The pathogenesis of BPD is multifactorial, and a complex view of this issue ("multiple hits" hypothesis) has emerged, which includes along with low gestational age and birthweight, antenatal exposure to a proinflammatory environment, and various postnatal inflammation-triggering events, such as mechanical ventilation, oxidative stress, sepsis, patent ductus arteriosus, and excessive fluid volume administration. 17,[39][40][41][42][43] Our results found similar risk factors for BPD as those described in literature.…”

Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants

“…Of 3170 potentially relevant studies, 158 (5.0%) met the inclusion criteria. The PRISMA flow diagram of the search process is shown in Figure 1.…”

“…Seventy-six studies were designed from the perspective of CA; they examined the outcomes of preterm infants with or without CA, and BPD was one of these outcomes. Sixty-seven studies were designed from the perspective of BPD; they studied risk factors for BPD, and CA was one of these risk factors. Sixteen studies were designed to primarily examine the association between CA and BPD.…”

The association of vitamin D and vitamin E levels at birth with bronchopulmonary dysplasia in preterm infants

“…Despite significant advances in perinatal care, BPD remains as one of the most common and intriguing diseases in perinatal medicine 2 . In recent years, with the in‐depth study of BPD, it has been found that mechanical ventilation damage and oxygen‐free radical peroxidation caused by mechanical ventilation are the key factors in the occurrence of the disease 3 . However, due to the imperfect pulmonary function of premature infants, continuous positive airway pressure is one of the important methods that are often adopted in early rescue 4 .…”