Abstract:Refractory pneumothoraces with bronchopleural fistula (BPF) pose a significant challenge in managing critically sick and ventilated neonates. We report a case of the term female neonate being treated with extracorporeal membrane oxygenation (ECMO) support for meconium aspiration and presumed sepsis, with a significant air leak refractory to pleural drainage that was managed using endobronchial application of cyanoacrylate (enbucrilate) glue to seal the leak.
“…Flexible bronchoscopy has been used to confirm and/or treat persistent BPF [157,158]. When a BPF is not clearly visible on bronchoscopy, selective bronchography at the suspected site may be utilised [159].…”
Paediatric airway endoscopy is accepted as a diagnostic and therapeutic procedure, with an expanding number of indications and applications in children. The aim of this European Respiratory Society task force was to produce a statement on interventional bronchoscopy in children, describing the evidence available at present and current clinical practice, and identifying areas deserving further investigation. The multidisciplinary task force panel performed a systematic review of the literature, focusing on whole lung lavage, transbronchial and endobronchial biopsy, transbronchial needle aspiration with endobronchial ultrasound, foreign body extraction, balloon dilation and occlusion, laser-assisted procedures, usage of airway stents, microdebriders, cryotherapy, endoscopic intubation, application of drugs and other liquids, and caregiver perspectives. There is a scarcity of published evidence in this field, and in many cases the task force had to resort to the collective clinical experience of the committee to develop this statement. The highlighted gaps in knowledge underline the need for further research and serve as a call to paediatric bronchoscopists to work together in multicentre collaborations, for the benefit of children with airway disorders.
“…Flexible bronchoscopy has been used to confirm and/or treat persistent BPF [157,158]. When a BPF is not clearly visible on bronchoscopy, selective bronchography at the suspected site may be utilised [159].…”
Paediatric airway endoscopy is accepted as a diagnostic and therapeutic procedure, with an expanding number of indications and applications in children. The aim of this European Respiratory Society task force was to produce a statement on interventional bronchoscopy in children, describing the evidence available at present and current clinical practice, and identifying areas deserving further investigation. The multidisciplinary task force panel performed a systematic review of the literature, focusing on whole lung lavage, transbronchial and endobronchial biopsy, transbronchial needle aspiration with endobronchial ultrasound, foreign body extraction, balloon dilation and occlusion, laser-assisted procedures, usage of airway stents, microdebriders, cryotherapy, endoscopic intubation, application of drugs and other liquids, and caregiver perspectives. There is a scarcity of published evidence in this field, and in many cases the task force had to resort to the collective clinical experience of the committee to develop this statement. The highlighted gaps in knowledge underline the need for further research and serve as a call to paediatric bronchoscopists to work together in multicentre collaborations, for the benefit of children with airway disorders.
“…IR techniques may be helpful in the identification and treatment of congenital or recurrent tracheoesophageal fistula, bronchoesophageal fistula, and bronchopleural fistula (BPF) . When enbucrilate (Histoacryl, B. Braun, Melsungen, Germany) is used to close a fistula, it may take a few seconds for the liquid adhesive to polymerize and form a plug, but prolonged apnea is not required.…”
Section: Airway Fistulasmentioning
confidence: 99%
“…Some form of general anesthesia is required in children . Diagnostic bronchography has been almost completely superseded by bronchoscopy, and by recent developments in computed tomography and magnetic resonance imaging, but is still useful as the basis of various image‐guided procedures, including balloon dilatation, stenting, and the treatment of airway fistulas . Many of these operations were pioneered by interventional radiologists (IRs), but pediatric surgeons and pulmonologists use the same or similar techniques .…”
Interventional procedures in the airway can be performed in interventional radiology suites or the operating room, by radiologists or other specialists. The most common therapeutic interventions carried out by radiologists are balloon dilatation, stenting, and the treatment of certain airway fistulas. These operations can be very challenging for anesthetists in terms of planning, airway management, the identification and treatment of procedural complications and postoperative care. In particular, a multidisciplinary approach to decision‐making and planning is important to obtain the best results.
“…Air-leak syndromes are rare as a primary cause of ECMO use outside of the neonatal period, but case reports demonstrate successful use of ECMO for air-leak syndromes that could imply similar success for patients with ventilator-induced lung injury in the setting of status asthmaticus. [130][131][132][133] Similar to inhaled anesthetics, extracorporeal lung support is a costly and resource-intensive therapy that is only clinically indicated for asthma patients failing other ther-apies. Unfortunately, some of these patients may be failing due to complications from mechanical ventilation that may be secondary to suboptimal management.…”
Asthma exacerbation is a common reason for children to present to the emergency department. If primary therapies fail to halt the progression of an asthma flare, status asthmaticus often leads to hospital, and potentially ICU, admission. Following the initial administration of inhaled β agonists and systemic corticosteroids, a wide array of adjunct medical therapies may be used to treat status asthmaticus. Unfortunately, the data supporting the use of these adjunct therapies are often unclear, conflicting, or absent. This review will present the physiologic basis and summarize the supporting data for a host of adjunct therapies, including ipratropium, intravenous β agonists, methylxanthines, intravenous and inhaled magnesium, heliox (helium-oxygen mixture), ketamine, antibiotics, noninvasive ventilation, inhaled anesthetics, and extracorporeal membrane oxygenation. Finally, we present a suggested care map for escalating to these therapies in children with refractory status asthmaticus.
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