Bronchogenic carcinoma: Clinicopathologic pattern in Nigerians.

Salami, Mudashiru A.; Adeoye, Peter Oladapo; Adegboye, V O

doi:10.1200/jco.2010.28.15_suppl.e12065

Cited by 6 publications

(5 citation statements)

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“…This finding is in concert with global reports that adenocarcinoma is the most common histologic type of lung cancer in both men and women, and in smokers and nonsmokers. 34 Our results differ from those of previous studies done in South Africa, 22 Egypt, 23 Tunisia, 24 Iran, 35 India, 32 , 36 , 37 Nepal, 38 Malaysia, 39 Nigeria, 31 and Senegal, 40 where SCC was the most common lung cancer cell type. These older studies may not reflect current rising trends of adenocarcinoma than SCC in most regions of the world, possibly owing to diagnostic advances, use of low tar-filtered cigarettes, and changes in smoking patterns.…”

Section: Discussioncontrasting

confidence: 90%

“…29,30 These factors have been supported in studies from other African countries, such as Nigeria and Morocco. 31,32 We were unable to clearly identify specific risk factors for lung cancer in our population. This may reflect patient selection, missing data, low cigarette use, and few reports of biomass exposure, which is unusual because the rate of biomass fuel use for cooking in Ethiopia is known to be very high.…”

Section: Discussionmentioning

confidence: 87%

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Clinical Characteristics and Molecular Profiles of Lung Cancer in Ethiopia

Gebremariam

Haisch

Fernandes

et al. 2021

JTO Clinical and Research Reports

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Introduction: Lung cancer is the most common cause of cancer deaths worldwide, accounting for 1.8 million deaths each year. Only 20% of lung cancer cases are reported to occur in low-and middle-income countries. An estimated 1.5% of all Ethiopian cancers involved the lung; however, no nationwide cancer registry exists in Ethiopia. Thus, accurate data on clinical history, histopathology, molecular characteristics, and risk factors for lung cancer are not available. The aim of this study was to describe the clinical, radiologic, and pathologic characteristics, including available molecular profiles, for lung cancer at Tikur Anbessa Specialized Hospital (TASH), the main tertiary referral center in Addis Ababa, Ethiopia. Methods: A cross-sectional study was conducted at TASH among 146 patients with pathologically confirmed primary lung cancer, diagnosed from 2015 to 2019 and recorded in the Addis Ababa Cancer Registry at TASH. Clinical data were extracted from patient medical records, entered into a Research Electronic Data Capture database, and analyzed using Statistical Package for the Social Sciences statistical software. Variables collected included sociodemographics, personal exposures, comorbidities, clinical manifestations at presentation, chest imaging results, diagnostic procedures performed, histopathological classification, cancer staging, and type of treatment (if any). A subset of lung biopsies fixed in formalin for 2 to 7 days, which could be retrieved from the files of the Pathology Department of TASH, were reviewed, and molecular analysis was performed using next-generation sequencing to identify the tumor-oncogenic drivers.Results: Among the 146 patients studied, the mean (SD) age was 54 plus or minus 13 years; 61.6% (n ¼ 90) were male and 25.3% (n ¼ 37) had a history of tobacco use. The most common clinical manifestations included cough (88.4%, n ¼ 129), chest pain (60.3%, n ¼ 88), and dyspnea (53.4%, n ¼ 78). The median duration of any symptoms was 6 months (interquartile range: 3-12 mo). The most common radiologic features were lung mass (84.9%, n ¼ 129) and

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 87%

Clinical Characteristics and Molecular Profiles of Lung Cancer in Ethiopia

Gebremariam

Haisch

Fernandes

et al. 2021

JTO Clinical and Research Reports

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“…29 human exposure to high concentrations of noxious gases induces respiratory ailments such as wheezing, asthma, chronic obstructive pulmonary disease and upper respiratory tract infection among others. According to Salami, 39 the rising cases of lung cancer among non-smokers in Nigeria are an indirect evidence of human exposure to diesel exhaust.…”

Section: Discussionmentioning

confidence: 99%

Degradation of urban environment and human health by emissions from fossil-fuel combusting electricity generators in Abeokuta metropolis, Nigeria

Oguntoke

Adeyemi

2016

Indoor and Built Environment

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Electricity generators of varying capacities are popularly utilized in Nigeria as alternative source of power owing to the unreliability of electricity supply through the national grid. This study evaluated the impact of emissions from generating sets on air quality and human health in selected areas of Abeokuta city, Nigeria. The levels of particulates (PM 1 , PM 3), carbon monoxide, carbon dioxide, sulphur oxides, nitrogen oxides, nitrogen dioxide, hydrogen sulphide and methane were monitored using portable samplers. Copies of questionnaire were administered to generator operators and nearby residents so as to collect additional information. The capacities of sampled generators ranged from 1 to 25 kVA. The range of mean concentrations of PM 1 (4.7-219.2 mg/m 3), PM 3 (7.8-251.6 mg/m 3), carbon dioxide (4.5-10.9%), methane (0.0-1.2 ppm), carbon monoxide (141.1-4167.0 ppm), NO x (4.0-85.7 ppm), methane (2.3-31.0 ppm), sulphur oxides (3.5-65.6 ppm) and hydrogen sulphide (0.0-0.7 ppm) was highest at generator sites. The distance of sample sites to generator locations accounted for 14-66% variation of pollutants levels. Ailments frequently suffered by the exposed residents included nasal congestion (66%), cough (33%), headache (24%) and fever (12%). A national policy on appropriate use of electricity generator is urgently needed in Nigeria.

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“…Empirical evidence has also suggested a link between occupational exposure to diesel exhaust and lung cancer in Europe and Canada (Olsson et al, 2011). Indirect evidence of the effect of diesel exhaust on lung cancer in Nigeria is indicative of its rising incidence among urban-based non-smoker adults (Salami, Adeoye, and Adegboye, 2010), most of whom are generator users. (Ogundipe, 2013).…”

Section: Figure 1 Herementioning

confidence: 99%

Get rid of it: To what extent might improved reliability reduce self-generation in Nigeria?

Oseni

2016

Energy Policy

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Despite the global concerns surrounding the threats of climate change to both human health and sustainable environments, gasoline-or diesel-powered generators with non-negligible emissions have become a popular choice among Nigerian households due to the poor publicly provided electricity. This study examines the extent to which an improvement in publicly supplied electricity may reduce backup generation and, by implication, reduce emissions from Nigerian homes. The results from a random-effects probit analysis reveal that, although improved electricity service quality would significantly reduce self-generation, self-generation would continue in the country, especially among rich and educated households. The study concludes by highlighting the policy implications of the findings.

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Bronchogenic carcinoma: Clinicopathologic pattern in Nigerians.

Cited by 6 publications

References 0 publications

Clinical Characteristics and Molecular Profiles of Lung Cancer in Ethiopia

Clinical Characteristics and Molecular Profiles of Lung Cancer in Ethiopia

Degradation of urban environment and human health by emissions from fossil-fuel combusting electricity generators in Abeokuta metropolis, Nigeria

Get rid of it: To what extent might improved reliability reduce self-generation in Nigeria?

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