Bronchogenic carcinoid metastasis to the intramedullary spinal cord

Intramedullary metastasis from a carcinoid tumor

“…Only two similar observations were found in the literature making this case noteworthy: a report of a spinal intramedullary teratoma with an associated carcinoid nodule [2] and a bronchogenic carcinoid metastasis of the intramedullary spinal cord [3].…”

“…Intramedullar metastases of the spinal cord are rare, especially in the conus medullaris [1,10]. Primitive tumors previously identified are: non-small-cell lung carcinomas, breast cancers, melanomas, thyroid tumors and certain lymphomas.Only two similar observations were found in the literature making this case noteworthy: a report of a spinal intramedullary teratoma with an associated carcinoid nodule [2] and a bronchogenic carcinoid metastasis of the intramedullary spinal cord [3].Neuroendocrine tumors are composed of secretory cells, which are characterized by their ability to express neuroendocrine markers such as chromogranin, NSE, synaptophysin and N-CAM (recognized by anti-CD56 antibodies) [4]. Specific hormone secretion can facilitate the discovery of a primitive tumor.…”

C8-T1 Radiculopathy Due to an Intradural Extramedullary Metastasis of a Pancreatic Neuroendocrine Tumor

“…15 In particular, 68 Ga-DOTA-NOC shows the broadest SSR affinity binding to SSR2, SSR3, and SSR5 and seems to be especially accurate in the detection of bone metastases from well-differentiated NETs. 15 To our knowledge, only 45 cases, including ours, of spinal cord compression due to metastases of well-differentiated NETs or to the very rarely occurring primary carcinoid tumors of the CNS [16][17][18][19][20] have been reported in the literature. We excluded spinal paragangliomas-often occurring as intradural extramedullary lesions-because they have been widely reported in the literature.…”

“…Carcinoid tumors were of bronchial (n = 9) and nonpulmonary origin (n = 17)-of which CNS (n = 2) and thymus (n = 3)-, and 4 patients had carcinoid tumors of unknown primary, whereas in 7 patients, the origin was not specified. [16][17][18][19][20][21][22][23][24][26][27][28][29][30][31][32]34,35,37,38,43 Only 6 pNET cases, including ours, of malignant spinal cord compression have been reported in the literature, 25,33,36,40,41 with two of them due to "functional" pNETs (ie, glucagonoma, gastrinoma). As far as we know, our case is the first ever reported of a pNETwith an "intradural" metastasis to the spinal cord, and we only found the following 4 other cases of spinal intradural NET metastases: 2 thymic carcinoids, 28,35 1 lung atypical carcinoid, 18 and a probable primary atypical carcinoid of the CNS.…”

Lumbar Intradural Metastasis from Large Cell Neuroendocrine Carcinoma of the Lung

“…Literature consists of case reports and reviews of small series. Carcinoid tumours are neuroendocrine cell originated malignant tumours (3). Usually, intradural carcinoma metastasis occur with past cure systemic cancer and indicate a short survival time (4)(5)(6)(7).…”