Bronchodilation Increases Estimated Ventilatory Capacity In Children With Mild Asthma

Ross, Nicholas; Wong, Michael; Kechkarian, Ani L.; Gould, Donna J.; Nakamura, Craig; Bhammar, Dharini M.

doi:10.1249/01.mss.0000684480.87994.f1

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“…These data were collected as part of a larger project comparing the effects of albuterol vs. high-intensity interval warm-up exercise on exercise-induced bronchoconstriction during constant work rate cycling exercise in children with asthma. Some data in this paper have been previously published in abstract form [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Effects of Albuterol on Ventilatory Capacity in Children with Asthma

Wong,

Chien,

Bhammar

2024

Pediatric Reports

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Background: Children with asthma may have a reduced ventilatory capacity, which could lead to symptoms and early termination of a cardiopulmonary exercise test (CPET). The purpose of this study was to examine the effects of short-acting beta agonist (albuterol) administration on estimated ventilatory capacity in children with asthma. Methods: Fifteen children (eleven boys, 10.6 ± 0.9 years) completed spirometry at baseline, after 180 µg of albuterol, and after the CPET in this cross-sectional study. Ventilatory capacity was calculated from forced vital capacity (FVC) and isovolume forced expiratory time from 25 to 75% of FVC (isoFET25–75) as follows: FVC/2 × [60/(2 × isoFET25–75)]. Differences in outcome variables between baseline, after albuterol administration, and after the CPET were detected with repeated measures mixed models with Bonferroni post hoc corrections. Results: Estimated ventilatory capacity was higher after albuterol (68.7 ± 21.2 L/min) and after the CPET (75.8 ± 25.6 L/min) when compared with baseline (60.9 ± 22.0 L/min; P = 0.003). Because forced vital capacity did not change, the increased ventilatory capacity was primarily due to a decrease in isoFET25–75 (i.e., an increase in mid-flows or isoFEF25–75). Conclusion: Albuterol administration could be considered prior to CPET for children with asthma with relatively well-preserved FEV1 values to increase ventilatory capacity pre-exercise and potentially avoid symptom-limited early termination of testing.

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Section: Introductionmentioning

confidence: 99%