Bronchodilating and Density Dependence Effects of Fenoterol, Ipratropium Bromide and Duovent in Reversible Chronic Obstructive Pulmonary Disease

Dubois, Pep.; Delwiche, J P; Minette, P.; Lulling, J.; Prignot, Jacques

doi:10.1159/000195146

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…Increased age is one of the factors significantly different in the subgroup with impaired exercise capacity and this is recognized as a limiting factor in general population. Central mechanisms involving cardiovascular (arterial stiffening, increased pulse pressure, decreased endothelium-mediated vasodilatation, increased left ventricular wall rigidity, prolonged myocardial contraction, prolonged early diastolic filling rate, decreased conduction times, sclerosis and calcification of the valves, autonomic nervous system changes) [10] and respiratory system [11] along with peripheral changes (sarcopenia) [12] represent a part of the background mechanisms decreasing effort capacity in elderly.…”

Section: Methodsmentioning

confidence: 99%

The predictors of exercise capacity impairment in diabetic patients

Frîngu¹,

Gușetu²,

Iosip³

et al. 2017

BALNEO

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Background. The exercise capacity is a key issue in a diabetic patient's management, due to its well-known beneficial effects in terms of glycemic control, cardiovascular risk reduction and quality of life improvement. However the exercise capacity of diabetic patients is decreased many times and its determinants are sometimes less known. Our study aimed to assess the effort capacity in a cohort of diabetic patients and to find the main causative factors of its impairment. Method: 61 patients with type-2 diabetes mellitus were enrolled and underwent and transthoracic echocardiography and a cycloergometer exercise testing. Exercise performance was calculated and the influence of clinical data and ultrasound parameters was assessed. Sedentary status of each patient was established from total time/week of at least moderate physical activity. Results: the study group consisted of 48.4 % women, mean age 61.4 (±8.4) years. Disease median duration was 5 years and 21.3 % of the patients presented neuropathy, 4.5 % retinopathy and 6.5 % nephropathy. Exercise capacity was moderately and severe decreased (<5 METs) in 37.7 % of patients and in this subgroup the diastolic dysfunction, sedentary behavior and old age has a significantly higher prevalence. Interestingly, by multivariate regression, the sedentary lifestyle was the main determinant of decreased effort capacity (beta-coefficient 1.37, p<0.001), suggesting the potential benefits of physical training in these patients. Conclusion. Our study found a decreased effort capacity in at least one third of the patients and this is mainly due to sedentary lifestyle and deconditioning, the diastolic dysfunction also contributes to decreased effort capacity in diabetic patients.

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Section: Methodsmentioning

confidence: 99%