Bronchoconstrictor Reactivity to NKA in Allergic Dogs: a Comparison to Histamine and Methacholine

House, Aileen; Celly, Chander; Young, Simon S.; Kreutner, William; Chapman, Richard W.

doi:10.1006/pupt.2001.0287

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…There are also models described using HDM as an antigen [ 156 ]. The HDM model has been used more recently for evaluation of treatments in the area of angiogenesis [ 157 , 158 ]. OVA, in combination with LPS, has been used to model eosinophilic, neutrophilic, and lymphocytic airway inflammation and lung remodeling [ 159 ].…”

Section: Inducible Animal Models Of Asthmamentioning

confidence: 99%

Asthma: The Use of Animal Models and Their Translational Utility

Woodrow

Sheats

Cooper

et al. 2023

Cells

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Asthma is characterized by chronic lower airway inflammation that results in airway remodeling, which can lead to a permanent decrease in lung function. The pathophysiology driving the development of asthma is complex and heterogenous. Animal models have been and continue to be essential for the discovery of molecular pathways driving the pathophysiology of asthma and novel therapeutic approaches. Animal models of asthma may be induced or naturally occurring. Species used to study asthma include mouse, rat, guinea pig, cat, dog, sheep, horse, and nonhuman primate. Some of the aspects to consider when evaluating any of these asthma models are cost, labor, reagent availability, regulatory burden, relevance to natural disease in humans, type of lower airway inflammation, biological samples available for testing, and ultimately whether the model can answer the research question(s). This review aims to discuss the animal models most available for asthma investigation, with an emphasis on describing the inciting antigen/allergen, inflammatory response induced, and its translation to human asthma.

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