Bronchocentric granulomatosis and central diabetes insipidus successfully treated with corticosteroids

Abstract

B Br ro on nc ch ho oc ce en nt tr ri ic c g gr ra an nu ul lo om ma at to os si is s a an nd d c ce en nt tr ra al l d di ia ab be et te es s i in ns si ip pi id du us s s su uc cc ce es ss sf fu ul ll ly y t tr re ea at te ed d w wi it th h c co or rt ti ic co os st te er ro oi id ds s We report a case of histologically confirmed pulmonary bronchocentric granulomatosis temporally associated with a partial central diabetes insipidus (CDI).Although the pathological basis of the posterior pituitary gland involvement was not ascertained, the temporal association of bronchocentric granulomatosis and central diabetes insipidus, as well as the fact that corticosteroid treatment provided stable remission of both conditions after a 10 month follow-up, strongly suggest that central diabetes insipidus was aetiologically related to bronchocentric granulomatosis in this patient.

The Classification of Pituitary Tumors: An Update

“…Treatment is somewhat controversial; transsphenoidal biopsy/resection with subsequent administration of corticosteroids has been proposed. 102,117 Microscopically, this condition is characterized by collections of histiocytes with scattered lymphocytes and plasma cells; multinucleated giant cells may be present. The diagnosis of idiopathic granulomatous hypophysitis cannot be made unless causes of secondary hypophysitis have been ruled out (see below).…”