Bronchoalveolar lavage: role in the evaluation of pulmonary interstitial disease

Hogea, Stanca-Patricia; Tudorache, Emanuela; Pescaru, Camelia; Marc, Monica; Oancea, Cristian

doi:10.1080/17476348.2020.1806063

Cited by 26 publications

(23 citation statements)

References 97 publications

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“…In routine bronchoscopy, we found no signi cant differences in comparing their examination times. The recovery rate of quali ed BALF should be more than 30% [14]. Our study found that both SFBs and RFBs could achieve satisfactory recovery rates, which was consistent with previous studies.…”

Section: Discussionsupporting

confidence: 92%

“…The operator xed the front end of the bronchoscope to the opening of the lesion, injected 20 ml warm saline solution into the lung segment through the working channel, and then gently aspirated the liquid (The pressure < 100 mmHg) into a sterile bottle for 3 times, The total volume of lavage was 60ml, and the amount recovered was recorded [12,13,14].…”

Section: Bronchoalveolar Lavagementioning

confidence: 99%

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Single-use flexible bronchoscopes vs traditional reusable flexible bronchoscopes: a prospective controlled study

Xie

Liu

et al. 2023

Preprint

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Background: Single-use flexible bronchoscopes（SFB）eliminate the risk of bronchoscopy-related infection compared with traditional reusable flexible bronchoscopes（RFB）. At present, there is no comparative study between SFB and RFB in the aspects of biopsy and interventional therapy. This study aims to explore whether SFB can perform complex bronchoscopic procedures such as transbronchial biopsies just like RFB. Methods: We conducted a prospective controlled study. A total of 45 patients who required bronchoscopic biopsy in our hospital from June 2022 to December 2022 were enrolled. The patients were divided into the SFB group and the RFB group, and routine bronchoscopy, bronchoalveolar lavage, and biopsy were performed respectively. Data on the time of routine bronchoscopy， the recovery rate of bronchoalveolar lavage fluid（BALF）, biopsy time, and bleeding volume were collected. We also designed a questionnaire to compare the performance between SFB and RFB by different bronchoscope operators. Results: The routine examination time of SFB and RFB was 3.40±0.50 min and 3.55±0.42 min, respectively. There was no significant difference between the two groups （P=0.308）. The recovery rate of BALF was （46.56±8.22）% in the SFB group and (47.00±8.07) in the RFB group, without a significant difference between the two groups（P=0.863）. The biopsy time was similar（4.67±0.51min VS 4.57±0.45 min） in both groups， with no significant difference（P=0.512）. The positive biopsy rate was 100% in both groups, with no significant difference. Overall, the bronchoscope operators were generally satisfied with SFB. Conclusion: SFBs are non-inferior to RFBs in routine bronchoscopy, bronchoalveolar lavage, and biopsy. It is suggested that SFBs have a wider clinical application.

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Section: Discussionsupporting

confidence: 92%

Section: Bronchoalveolar Lavagementioning

confidence: 99%

Single-use flexible bronchoscopes vs traditional reusable flexible bronchoscopes: a prospective controlled study

Xie

Liu

et al. 2023

Preprint

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“…Alveolar macrophages may exhibit a foamy appearance in HP, which indicates an intense process of phagocytosis. BAL is not diagnostic of HP but supports the diagnosis (6,8,9). If the diagnosis cannot be established by the methods described above, a lung biopsy will be considered.…”

Section: Discussionmentioning

confidence: 98%

Hypersensitivity pneumonitis – acceptance of the diagnosis

et al. 2020

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Hypersensitivity pneumonia (HP) is an inflammatory lung syndrome due to repetitive exposure to small organic particles. The etiological agents of the disease are diverse and can be represented by fungi, bacteria, small molecule chemical compounds, as well as proteins from animals or insects. We present the case of a 25-year-old male, who was admitted to our Pulmonology Clinic for the following symptoms: morning cough with mucosal sputum for about 2 years, moderate exertional dyspnea (mMRC 3) started for 2 months, weight loss of about 6 kg in the past 5 months and fatigue. Clinical examination revealed bilateral mid- basal crackling rales. Chest high-resolution computed tomography (HRCT) (multiple micronodular opacities, diffuse contoured, bilaterally disseminated), lung function tests (restrictive ventilatory dysfunction with decreased carbon monoxide diffusing capacity), bronchoalveolar lavage (BAL) (lymphocyte alveolitis) and serological tests (positive antibodies for pigeon heathers and dejections) pointed to the diagnosis of hypersensitivity pneumonitis. It was recommended to avoid exposure to pigeons, as the patient was a pigeon breeder. Prednisone treatment was initiated. The general condition of the patient 1 month after diagnosis had improved, the evolution being good under treatment.

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“…Bronchoalveolar lavage fluid (BALF) is a noninvasive, well‐tolerated procedure that is an important diagnostic tool for the diagnosis of various lung diseases. 11 Metagenomic next‐generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) has the potential to improve pathogen identification in community‐acquired pneumonia (CAP). 12 As a new pathogen detection technology, metagenomic next‐generation sequencing (mNGS) is increasingly used in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and pathogen analysis of bronchoalveolar lavage fluid in elderly patients with community‐acquired pneumonia

Guo

Zhang

Zhu

et al. 2023

Immunity Inflam & Disease

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Objective To analyze the clinical characteristics and bronchoalveolar lavage fluid pathogens in elderly patients with community‐acquired pneumonia (CAP). Methods This was a retrospective observational epidemiological study using that elderly cases diagnosed with community‐acquired pneumonia receiving treatment at the Affiliated Hospital of North China University of Technology, Tangshan Hongci Hospital and Tangshan Fengnan District Hospital of Traditional Chinese Medicine. A total of 92 cases were divided into two groups according to age. There were 44 patients over 75‐year‐old and 48 patients between 65 and 74‐year‐old. Results Compared with the elderly 65 to 74‐year‐old, the elderly over 75‐year‐old with diabetes are more likely to suffer from CAP (35.42% vs. 63.64%, p = 0.007) and are more likely to have mixed infections (6.25% vs. 22.73%, p = 0.023) or larger lesions (45.83% vs. 68.18%, p = 0.031). Their hospital stays will also be extended (39.58% vs. 63.64%, p = 0.020), and the albumin level (37.51 ± 8.92 vs. 30.93 ± 6.58, p = 0.000), the neutrophils level (9.09(6.26–10.63) vs. 7.18(5.35–9.17),p = 0.026) is significantly lower and the d‐dimer (505.42 ± 197.12 vs. 611.82 ± 195.85, p = 0.011), PCT (0.08 ± 0.04 vs. 0.12 ± 0.07, p = 0.001) levels are significantly higher. Conclusion The clinical symptoms and signs of elderly CAP patients are not so typical, and the infection is more serious. Attention should therefore be paid to elderly patients. Hypoalbuminemia and high d‐dimer can predict the prognosis of patients.

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Bronchoalveolar lavage: role in the evaluation of pulmonary interstitial disease

Cited by 26 publications

References 97 publications

Single-use flexible bronchoscopes vs traditional reusable flexible bronchoscopes: a prospective controlled study

Single-use flexible bronchoscopes vs traditional reusable flexible bronchoscopes: a prospective controlled study

Hypersensitivity pneumonitis – acceptance of the diagnosis

Clinical characteristics and pathogen analysis of bronchoalveolar lavage fluid in elderly patients with community‐acquired pneumonia

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