Bronchoalveolar lavage cytokine profile in a cohort of lung transplant recipients: A predictive role of interleukin-12 with respect to onset of bronchiolitis obliterans syndrome

Analysis of cytokine pattern in exhaled breath condensate of lung transplant recipients with bronchiolitis obliterans syndrome

“…Many cytokines, for example, IL-8 or transforming growth factor (TGF)-b 1 that are often found to be elevated in the lavage of BOS patients [15,16] were not up-regulated in our assay. By contrast, the high IL-13 level in the lavage of BOS patients found in the study of Keane et al [7] is in agreement with our results.…”

A model of chronic lung allograft rejection in the rat

“…Changes in this balance can influence allograft airway remodelling. Low levels of IL-12 were demonstrated to predict the development of BO syndrome in humans [24], whereas the domination of the Th2 response was favoured in promoting CR [25]. In a rodent heterotopic tracheal Tx model, NEURINGER et al [26] suggested both pathways of Th to play a role during the development of CR, whereas others provided dichotomous findings regarding the role of Th1/Th2 [9,27].…”

Comparison of Induced Sputum and Bronchoalveolar Lavage in Lung Transplant Recipients

“…10,12,13 Biologic mediators have been proposed as early markers of OB. 14,15 We showed that bronchoalveolar lavage (BAL) neutrophilia 16 as well as interleukin-8 (IL-8) and chemokine ligand 5 (CCL-5) RANTES (regulated on activation: normal T cell expressed and secreted) 17 levels were increased in BOS patients before the classic criteria of BOS were met based on the decline in FEV 1 . Even if BAL is a potent tool for diagnosis of pulmonary complications in lung transplant recipients (LTRs), 18,19 it remains an invasive procedure that cannot be performed as often as would be necessary to detect early variation of markers relevant to OB.…”