Bronchoalveolar lavage amylase levels can be a biomarker of aspiration pneumonia

Saitou, Miwako; Utano, Yuka; Utano, Kennichi; Niitsuma, Katsunao

doi:10.1183/13993003.congress-2020.2354

Cited by 2 publications

(2 citation statements)

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“…Cell death causes a release of fibrogenic factors, which lead to the activation of the growth of connective tissue. An increase in the level of amylase in BALF has been shown in inflammatory and carcinogenic lesions of the lungs [44][45][46], as well as in the exacerbation of chronic obstructive pulmonary disease [47] and aspiration pneumonia [48,49]. All the above processes are accompanied by inflammation and cell proliferation, be it tumor cells or fibroblasts.…”

Section: Relationship Between the Chemical Composition Of Nanoparticl...mentioning

confidence: 99%

Comparative Evaluation of the Cytotoxic Effects of Metal Oxide and Metalloid Oxide Nanoparticles: An Experimental Study

Sutunkova

Klinova

Ryabova

et al. 2023

IJMS

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Industrial production generates aerosols of complex composition, including an ultrafine fraction. This is typical for mining and metallurgical industries, welding processes, and the production and recycling of electronics, batteries, etc. Since nano-sized particles are the most dangerous component of inhaled air, in this study we aimed to establish the impact of the chemical nature and dose of nanoparticles on their cytotoxicity. Suspensions of CuO, PbO, CdO, Fe2O3, NiO, SiO2, Mn3O4, and SeO nanoparticles were obtained by laser ablation. The experiments were conducted on outbred female albino rats. We carried out four series of a single intratracheal instillation of nanoparticles of different chemical natures at doses ranging from 0.2 to 0.5 mg per animal. Bronchoalveolar lavage was taken 24 h after the injection to assess its cytological and biochemical parameters. At a dose of 0.5 mg per animal, cytotoxicity in the series of nanoparticles changed as follows (in decreasing order): CuO NPs > PbO NPs > CdO NPs > NiO NPs > SiO2 NPs > Fe2O3 NPs. At a lower dose of 0.25 mg per animal, we observed a different pattern of cytotoxicity of the element oxides under study: NiO NPs > Mn3O4 NPs > CuO NPs > SeO NPs. We established that the cytotoxicity increased non-linearly with the increase in the dose of nanoparticles of the same chemical element (from 0 to 0.5 mg per animal). An increase in the levels of intracellular enzymes (amylase, AST, ALT, LDH) in the supernatant of the bronchoalveolar lavage fluid indicated a cytotoxic effect of nanoparticles. Thus, alterations in the cytological parameters of the bronchoalveolar lavage and the biochemical characteristics of the supernatant can be used to predict the danger of new nanomaterials based on their comparative assessment with the available tested samples of nanoparticles.

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Section: Relationship Between the Chemical Composition Of Nanoparticl...mentioning

confidence: 99%

Comparative Evaluation of the Cytotoxic Effects of Metal Oxide and Metalloid Oxide Nanoparticles: An Experimental Study

Sutunkova

Klinova

Ryabova

et al. 2023

IJMS

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“…BAL fluid amylase level of 204 U/L or more had a sensitivity and specificity of 78.6 and 82.8%, respectively with an area under its receiver operating characteristic curve of 0.859 (95% CI: 0.803-0.915) for the diagnosis of aspiration pneumonia. 13 Similarly, CT has more accuracy than a bedside X-ray in diagnosing pneumonia. Moreover, the patients in the ED requiring intubation may have evolving community-acquired pneumonia, that manifested only after 48 hours and is labeled as aspiration pneumonia.…”

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Aspiration Pneumonia after Rapid Sequence Intubation: A Diagnostic Dilemma!

Mohammed¹

2020

Indian Journal of Critical Care Medicine

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A bstract Rapid sequence intubation (RSI) is generally done in the patients requiring intubation in the emergency room. These patients are often full stomach and are at the risk of regurgitation and aspiration leading to aspiration pneumonia. The incidence of aspiration pneumonia during RSI is not known as the term “RSI” is poorly defined and the diagnosis of aspiration pneumonia is often clinical and circumstantial. How to cite this article: Bhatia PK, Mohammed S. Aspiration Pneumonia after Rapid Sequence Intubation: A Diagnostic Dilemma! Indian J Crit Care Med 2021;25(2):111–112.

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Bronchoalveolar lavage amylase levels can be a biomarker of aspiration pneumonia

Cited by 2 publications

References 0 publications

Comparative Evaluation of the Cytotoxic Effects of Metal Oxide and Metalloid Oxide Nanoparticles: An Experimental Study

Comparative Evaluation of the Cytotoxic Effects of Metal Oxide and Metalloid Oxide Nanoparticles: An Experimental Study

Aspiration Pneumonia after Rapid Sequence Intubation: A Diagnostic Dilemma!

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