Broncho-Vaxom Attenuates Allergic Airway Inflammation by Restoring GSK3β-Related T Regulatory Cell Insufficiency

R, Fu; Li, Jian; Zhong, Hua; Yu, Dehong; Zeng, Xiaofeng; Deng, Minhua; Sun, Yueqi; Wen, Wang; Li, Hua-Bin

doi:10.1371/journal.pone.0092912

Cited by 30 publications

(32 citation statements)

References 24 publications

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“…This enzyme is present in the stomach and preferentially hydrolyses proteins in acidic conditions. The resistance of the bacterial extract to gastric buffer supports numerous studies showing evidence of immune modulation of the respiratory tract following oral administration of OM-85 [4,6,16,[26][27][28][29].…”

Section: Discussionsupporting

confidence: 71%

Biomarkers Induced by the Immunomodulatory Bacterial Extract OM-85: Unique Roles for Peyer’s Patches and Intestinal Epithelial Cells

Manolova¹,

Flace²,

Je³

et al. 2017

J Clin Cell Immunol

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Section: Discussionsupporting

confidence: 71%

Biomarkers Induced by the Immunomodulatory Bacterial Extract OM-85: Unique Roles for Peyer’s Patches and Intestinal Epithelial Cells

Manolova¹,

Flace²,

Je³

et al. 2017

J Clin Cell Immunol

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“…If future studies including sampling of local or systemic inflammatory processes (35,36) can show that those mechanisms play an important role in viral colonization during infancy and in shaping the microbiota-immune balance, preventative measures, such as vaccination or application of probiotics, could be directed against those processes. Although further studies are clearly needed to confirm this hypothesis, the first studies have already shown a possibly preventive effect of probiotics on respiratory infection in general and HRV infection in particular (37,38).…”

Section: Discussionmentioning

confidence: 99%

Interactions of Respiratory Viruses and the Nasal Microbiota during the First Year of Life in Healthy Infants

Korten

Mika

Klenja

et al. 2016

mSphere

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Respiratory viral infections are very frequent in infancy and of importance in acute and chronic disease development. Infections with human rhinovirus (HRV) are, e.g., associated with the later development of asthma. We found that only symptomatic HRV infections were associated with acute changes in the nasal microbiota, mainly characterized by a loss of microbial diversity. Infants with more frequent symptomatic HRV infections had a lower bacterial diversity at the end of the first year of life. Whether the interaction between viruses and the microbiota is one pathway contributing to asthma development will be assessed in the follow-ups of these children. Independent of that, measurements of microbial diversity might represent a potential marker for risk of later lung disease or monitoring of early life interventions.

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“…Bacterial lysates, immunoregulatory cellular extracts that have been found to reduce allergic airway inflammation in mouse models, may be an effective alternative [95–97]. The most studied bacterial lysate is OM-85 BV, which contains extracts derived from 8 bacterial species: Staphylococcus aureus, Streptococcus species , Klebsiella species , Neisseria catarrhalis and Haemophilus influenzae .…”

Section: Potential Benefit Of Immunostimulant Microbial Exposuresmentioning

confidence: 99%

Strategies to alter the natural history of childhood asthma

Lee-Sarwar

Bacharier

Litonjua

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Asthma exhibits significant heterogeneity in occurrence and severity over the lifespan. Our goal is to discuss recent evidence regarding determinants of the natural history of asthma during childhood, and review the rationale behind and status of major efforts to alter its course. Recent findings Variations in microbial exposures are associated with risk of allergic disease, and the use of bacterial lysates may be a promising preventive strategy. Exposure to air pollution appears to be particularly damaging in prenatal and early life, and interventions to reduce pollution are feasible and result in clinical benefit. E-cigarette use may have a role in harm reduction for conventional cigarette smokers with asthma, but has undefined short- and long-term effects that must be clarified. Vitamin D insufficiency over the first several years of life is associated with risk of asthma, and vitamin D supplementation reduces the risk of severe exacerbations. Summary The identification of risk factors for asthma occurrence, persistence and severity will continue to guide efforts to alter the natural history of the disease. We have reviewed several promising strategies that are currently under investigation. Vitamin D supplementation and air pollution reduction have been shown to be effective strategies and warrant increased investigation and implementation.

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Broncho-Vaxom Attenuates Allergic Airway Inflammation by Restoring GSK3β-Related T Regulatory Cell Insufficiency

Cited by 30 publications

References 24 publications

Biomarkers Induced by the Immunomodulatory Bacterial Extract OM-85: Unique Roles for Peyer’s Patches and Intestinal Epithelial Cells

Biomarkers Induced by the Immunomodulatory Bacterial Extract OM-85: Unique Roles for Peyer’s Patches and Intestinal Epithelial Cells

Interactions of Respiratory Viruses and the Nasal Microbiota during the First Year of Life in Healthy Infants

Strategies to alter the natural history of childhood asthma

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