Bronchioloalveolar Carcinoma in a Juvenile Rhadomyosarcoma Patient

Abstract

Primary tumors of the lung are uncommon in pediatric patients, particularly bronchioloalveolar carcinoma (BAC). An 11-year-old female suffering from back pain for 1 month was referred to Seoul St. Mary's Hospital for treatment of a pathologic fracture of the lumbar spine. Comprehensive evaluation disclosed numerous pulmonary metastases of rhabdomyosarcoma (stage IV). During chemotherapy, most of the lung lesions regressed, with the exception of two nodules. Wedge resections, intended for diagnosis and cure, yielded a histologic diagnosis of BAC.

Second Malignant Neoplasms in Rhabdomyosarcoma: Victims of Our Own Success or an Underlying Genetic Predisposition Syndrome?

“…Interestingly, this SMN developed outside of the patient's radiation field and with a relatively short latency from diagnosis, suggesting that an underlying genetic cancer predisposition may be contributing. The occurrence of minimally invasive adenocarcinoma of the lung in a young patient with metastatic RMS has only been previously described once in the literature . In contrast to the case presented by Bradee et al., the adenocarcinoma in this patient was likely present at diagnosis of pulmonary metastatic RMS, as two nodules that failed to resolve with RMS‐directed therapy were found to both be minimally invasive adenocarcinoma.…”

Minimally Invasive Adenocarcinoma of the Lung as Second Malignant Neoplasm Following Pediatric Rhabdomyosarcoma

“…AIS has also been reported as a SMN following a variety of pediatric cancers . Choi et al recently published the only reported case of AIS as a SMN after RMS . They describe an 11‐year‐old female presenting with stage IV RMS of unspecified non‐pulmonary origin with concurrent lung nodules.…”