Bronchiectasis: Retrospective Analysis of Clinical and Pathological Findings in a Tertiary-Care Hospital

Abstract

Background. Bronchiectasis is still a challenging chronic lung disease in developing countries. Patients with bronchiectasis can also have pulmonary hypertension. There are sparse data on the prevalence of pulmonary hypertension in patients with bronchiectasis. Materials and methods. Archived H&E-stained slides of 141 patients histopathologically diagnosed with bronchiectasis were reevaluated. Cases were categorized into 4 subgroups based on histology: tubular, varicose, follicular, and cystic. In addition, concomitant histopathological changes were also reevaluated. For patients with available CT sections, main, right, and left pulmonary artery (PA) diameters and PA/aorta ratio were measured with regard to pulmonary hypertension. Results. Of the cases, 70% (n = 89) were female and 30% (n = 52) were male, with a mean age of 36.58 in females and 33.84 in males. Histopathologically, 43% (n = 68) of the cases showed follicular, 37% (n = 59) showed varicose, 35% (n = 56) showed tubular, and 28% (n = 45) showed cystic bronchiectasis morphology. All cases showed chronic inflammation, fibrosis, muscle destruction, and cartilage destruction. Aspergillus were present in 11% of the cases showing cystic morphology. Approximately 17% of the cases (n = 24) were found to have neuroendocrine cell proliferations. In cases with medial hypertrophy, a statistically significant increase in the left pulmonary artery diameter was radiologically determined. Conclusions. Medial hypertrophy was found to be significant with regard to indicating a radiological increase in left pulmonary artery diameter. Vascular changes observed in bronchiectasis cases and the presence of neuroendocrine cell proliferations should be specified in pathology reports, and aspergilloma should be carefully investigated in cases with predominant cystic morphology.

Proposed Etiotypes for Chronic Obstructive Pulmonary Disease: Controversial Issues

“…The pathology of bronchiectasis is also different from classical COPD in terms of major involvement sites. While classical COPD is characterized by alveoli involvement and/or small airway involvement [ 18 ], the structural dilatation of bronchi is the main characteristic of bronchiectasis, although bronchiectasis is often accompanied by bronchiolitis or bronchiolitis ( Table 3 ) [ 19 ]. Rapid lung function decline is an important pathophysiology leading to COPD.…”

Pengaruh Pemberian Ekstrak Biji Kopi Robusta (Coffea canephora) Lampung terhadap Aktivitas Enzim Katalase Hippocampus Tikus Putih (Rattus norvegicus) Jantan Galur Sprague dawley yang Diinduksi Monosodium Glutamat

“…Bronkiektasis merupakan penyakit paru kronis yang ditandai dengan pelebaran saluran bronkus yang persisten disertai dengan penurunan fungsi transportasi mukosiliar akibat infeksi bakteri dan penumpukan lendir pada bronkus. 1 Bronkiektasis pertama kali dijelaskan oleh Laennec pada abad ke-19, prevalensi bronkiektasis di Eropa dan Amerika utara berkisar 67 sampai 566.1 per 100000 penduduk, selain itu di China bronkiektasis pada usia lebih dari 40 tahun mencapai 1200 per 100.000 penduduk. 2 Sindrom Obstruksi Pasca Tuberkulosis (SOPT) adalah gangguan paru yang ditandai adanya obstruksi saluran napas kronik akibat komplikasi yang timbul dari tuberkulosis paru pasca pengobatan.…”